severe – Page 13 – Communicable Diseases Research

A computational analysis of SARS cysteine proteinase-octapeptide substrate interaction: implication for structure and active site binding mechanism

Research

Published on 2009-01-302022-10-27
Journal: BMC Bioinformatics [Category] Coronavirus,

Duration of Antibody Responses after Severe Acute Respiratory Syndrome

Dispatch

Published on 2007-10-012022-10-31
Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS,

[키워드] acute respiratory syndrome antibodies antibody average convalescent dispatch Duration Immunoglobulin initial longitudinal study occurred Patient reduction Reinfection respiratory response SARS SARS patient severe susceptible
[DOI] 10.3201/eid1310.070576 PMC 바로가기 [Article Type] Dispatch

Pathogenetic mechanisms of severe acute respiratory syndrome

Article

Published on 2007-09-072022-11-01
Journal: Virus research [Category] Coronavirus, MERS,

[키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while
[DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Research Article

Published on 2007-08-102022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication
[DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article

Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV)

Research

Published on 2007-03-272022-10-28
Journal: Virology Journal [Category] Coronavirus,

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Research Article

Published on 2006-12-262022-10-29
Journal: PLoS Medicine [Category] Coronavirus, Fulltext, 조류인플루엔자,

[키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic
[DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article

SARS: Systematic Review of Treatment Effects

Research Article

Published on 2006-09-122022-10-29
Journal: PLoS Medicine [Category] Coronavirus,

[키워드] 2003 active against acute respiratory distress acute respiratory syndrome adverse effect affected antiviral drug ARDS Author be applied Blood carried caused CENTRAL China clinical clinical trial clinician conducted Controlled convalescent plasma Corticosteroids cough criteria Culture database death death rate determine disease dosage drug Effect effective Effectiveness Evidence example Fever finding found group had no Health care help helping HIV/AIDS identify IFN IFN type I immune system immunoglobulins In vitro studies in vitro study include inclusion criteria Inconclusive Inflammation information Intravenous immunoglobulin Laboratory life-threatening Lungs MedlinePlus MONITOR NO occurred outbreak Outbreaks Patient patients patients with SARS Pneumonia Potential treatment Protein protocol real time recommendation reduce reduced reported Research researcher review ribavirin Ritonavir SARS patients SARS-CoV SARS-infected patient SARS-infected patients searched severe sneeze Source specific symptom steroid Steroids Symptom syndrome systematic review the WHO tissue treat Treatment Trial Type I IFN type I interferon viral disease virus viruses Web while WHO Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030343 PMC 바로가기 [Article Type] Research Article

Preparation and characterization of a novel monoclonal antibody specific to severe acute respiratory syndrome-coronavirus nucleocapsid protein

Article

Published on 2006-08-302022-11-01
Journal: Virus research [Category] Coronavirus,

Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003

Research Article

Published on 2006-08-142022-10-28
Journal: BMC Public Health [Category] Coronavirus,

[키워드] 2003 95% confidence interval activity Analysis antibody assigned attack rate calculated Care Case-control category collected Community coronavirus cough detected disease Evidence Factor Fever group healthcare worker help highest highlight Hong Kong hospital implication increased risk individuals Infection Influenza lowest nosocomial Nurse occurred other respiratory infection outbreak Patient recommendation reported respiratory Result risk risk factor SARS-CoV SARS-CoV infection serologic serum severe specimen Spread subsequent Symptom the patient Transmission Univariate analysis was performed
[DOI] 10.1186/1471-2458-6-207 PMC 바로가기 [Article Type] Research Article

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome

Research Article

Published on 2006-05-182022-10-29
Journal: PLoS Medicine [Category] Coronavirus, MERS,

[키워드] 2003 acute respiratory syndrome Adequate affected animal animal model cause caused changed Chest radiograph children clinical disease Clinical laboratory test clinically clone coronavirus cynomolgus macaque demonstrated develop disease effective vaccine Evidence finding group Health Infected Infection infectious intravenous intravenously Jason macaque majority Mild Model moderate mucosal route nare Neutralizing antibodies NHP NHPs parameter Pathogenesis peaked Pneumonia Postinfection produced required respiratory SARS-CoV SARS-CoV infection SARS-CoV Urbani severe significantly similarity symptomatic syndrome viral replication virus were infected wild-type
[DOI] 10.1371/journal.pmed.0030149 PMC 바로가기 [Article Type] Research Article