A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable LiteraturePharmacology Published on 2021-08-112022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] administration antagonist action approach approaches clinical trial clinician Confusion Course COVID-19 disease ontology dosage drug Drug discovery experimental design Famotidine histamine (H2) receptor IMPROVE independent information knowledge Knowledge graph literature Meta-analysis methodological ontological outcome placebo-controlled potential benefit Randomized reflect regimen reported resolved retrospective Retrospective study statistical analysis Stratification therapeutic indications turn utility Validity Variability variable [DOI] 10.3389/fphar.2021.700703 PMC 바로가기 [Article Type] Pharmacology
Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID studyObservational Study Published on 2021-08-062022-10-04 Journal: Critical Care [Category] MERS, 임상, [키워드] ΔP 28-day mortality acute respiratory distress Acute respiratory failure addition adjusted Analysis ARDS association calculated Cohort collected comparable confidence interval confounder coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill driving Driving pressure Evidence fixed higher risk ICU independent intensity invasive ventilation invasively ventilated patient Mechanical power Mechanical power of ventilation Mortality multicenter observational study National outcome parameter Patient patients primary endpoint prognostic biomarker quartile receiving reflected Respiratory failure Result Stratification stratified supplementary material syndrome translate Ventilated Ventilation were used [DOI] 10.1186/s13054-021-03710-6 PMC 바로가기 [Article Type] Observational Study
Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risksReview Published on 2021-08-032022-10-31 Journal: The EPMA Journal [Category] COVID-19, [키워드] affected aggression Anti-inflammation, Antibacterial Anti-inflammatory antioxidant antiviral properties Antiviral, COVID-19 applied ARDS Cancer Cancer, Chronic diseases Care chronic inflammation clinical utility Complication Coumarins COVID-19 COVID-19 infection Cytokine storm disease disease management Diseases disorder Effect effective Evidence flavonoids Health health condition Health economy Health policy healthcare Immunity individual Inflammation Isolation life-threatening lung damage Mental metabolic disorder mitigate neurologic obesity pandemic Pathologies Patient Periodontitis Personalized medicine phenolic acids Phenolic compounds phytochemicals Predictive Predictive preventive personalized medicine (3PM/PPPM) PROTECT reflected risk Risk assessment signaling pathways sleep quality smoking stilbenoids Stratification subgroup Support targeting Therapy efficacy vascular dysfunction [DOI] 10.1007/s13167-021-00249-y PMC 바로가기 [Article Type] Review
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility임신에서 ACE2의 역할과 COVID-19 감수성에 대한 잠재적 영향Review Published on 2021-08-022022-09-11 Journal: Clinical Science (London, England : 1979) [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 ACE2 protein acute respiratory syndrome angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme cardiovascular disease cells changes in children circulation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility Critical deplete disease manifestation disorder during pregnancy Effect Evidence evidence of feature Follow-up hemodynamic impair implication IMPROVE indicate Infection information Kinin knowledge main receptor management mechanism molecular mother organ physiological system physiological systems Placenta placental biology placentation pregnancies Pregnancy Protective RAS renin–angiotensin system Replication respiratory risk role SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome Significant Stratification Transmission vertical transmission Viral viral entry viral infection with COVID-19 [DOI] 10.1042/CS20210284 PMC 바로가기 [Article Type] Review
Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort studyResearch article Published on 2021-08-012022-10-05 Journal: The Lancet Rheumatology [Category] 바이오마커, [키워드] Acute kidney injury Altered mental status Analysis approach Biomarker center characteristic chemokine children Cincinnati clinical Coagulopathy cohort of patient cohort study Concentration concentrations conditions CXCL9 Deutsche Forschungsgemeinschaft diagnosed Diagnosis eight elevated ELISA enrolled family finding FIVE foundation Frequency funding Hyperinflammatory Hyperinflammatory syndrome IL-18 IL-6 Inflammatory Inflammatory biomarker juvenile idiopathic arthritis Kawasaki disease Laboratory laboratory feature Ligand macrophage activation macrophage activation syndrome management median median age MIS-C motif Myocardial dysfunction nine non-parametric test occur Pathogenesis pathophysiology Patient potentially life-threatening prospective cohort Protein provide S100A12 SARS-COV-2 infection Sensitivity and specificity Seven severity Shock significantly higher skin Stratification Support syndrome systemic inflammatory marker USA was done were assessed [DOI] 10.1016/S2665-9913(21)00139-9 [Article Type] Research article
Prevalence of unmasked and improperly masked behavior in indoor public areas during the COVID-19 pandemic: Analysis of a stratified random sample from Louisville, KentuckyResearch Article Published on 2021-07-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] average COVID-19 COVID-19 transmission facial less limit majority male measurement observation Observing Prevalence random Significant Stratification stratified USA was selected wearing [DOI] 10.1371/journal.pone.0248324 PMC 바로가기 [Article Type] Research Article
Individual- and Institutional-level Concerns of Health Care Workers in Canada During the COVID-19 Pandemic A Qualitative AnalysisResearch Published on 2021-07-272022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] addressed Affect Analysis analyzed anonymously Canada Care concern Contamination COVID-19 COVID-19 pandemic Critical distress finding HCW HCWs Health Health care worker hospital Importance individual Intervention Major manifested measure mental health objective pandemic Pandemics participant Personal protective equipment Point Potential Qualitative question ranged Relevance reported Result risk setting Stratification study period submitted Support university was performed worker [DOI] 10.1001/jamanetworkopen.2021.18425 PMC 바로가기 [Article Type] Research
Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort studyClinical Science Published on 2021-07-252022-10-28 Journal: Rheumatology (Oxford, England) [Category] COVID-19, [키워드] 1.26 95% CI age Analysis calibrated cohort study Community concern coronavirus disease country Cox model Depression dose electronic medical record epidemiology, RA estimate event events Germany hazard ratio HCQ Hospitalization HRs hydroxychloroquine treatment ideation indication negative control no effect objective outcome pandemic PAS Patient performed Propensity score Psychiatric Psychosis raised Regulatory Result rheumatology risk Safety Stratification Study protocol treat Treatment USA were used [DOI] 10.1093/rheumatology/keaa771 PMC 바로가기 [Article Type] Clinical Science
Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance studyOriginal Article Published on 2021-07-222022-10-27 Journal: Brain Communications [Category] COVID-19, [키워드] addition Admission Adults age association Atypical cerebrovascular Cerebrovascular disease clinical Clinical data Clinical outcome clinical trials clinical variables Comorbidities Complication conditions COVID-19 cross-sectional delirium demographics determine diagnose disease disorder Encephalopathy event Factor frailty greater groups hospitalized patient identify independent Inflammatory intensive care less Logistic regression neurological NEUROLOGY occurred Older age outcome overlapping pandemic Patient patients phenotype Physicians predicted Prognosis Psychiatric psychiatric condition psychiatrists rates of admission relative reported respiratory symptoms risk factor Risk factors SARS-CoV-2 severe COVID-19 Spectrum Stratification stroke Surveillance therapeutic interventions threshold Thrombotic events Ventilation was performed were used white cell with COVID-19 [DOI] 10.1093/braincomms/fcab168 PMC 바로가기 [Article Type] Original Article
Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based studyResearch Article Published on 2021-07-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] 95% CI age association blood glucose BMI body mass index clinical implication cohort study controlling COVID-19 COVID-19 severity death defined diabete diabetes diagnose Diagnosis Effect elevated exposure Factors fasting blood Gender Glucose hemoglobin Hospitalization hypertension ICU admission Importance increased risk Infection ischemic heart disease lowest male New objective Patient Population positive pre-diabete recent required Research Result resulting risk risk factor setting severe coronavirus disease severe COVID-19 severe disease Stratification [DOI] 10.1371/journal.pone.0254847 PMC 바로가기 [Article Type] Research Article