Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strainSARS-CoV-2 게놈에서 COVID-19 사망률 위험에 대한 게놈 차원의 연관성 분석은 브라질 균주의 P.1과 함께 국소화되는 SARS-CoV-2 스파이크 단백질의 돌연변이를 식별합니다Article Published on 2021-10-012022-09-11 Journal: Genetic epidemiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] Affect Alter Amino acid analyses Analysis analyzed approach association Brazil can not center change coding sequences Containment Control COVID-19 mortality COVID-19 patient database databases defined disease control driven by ENhance Follow-up Frequency Genome-wide association studies Genome-wide association study genome-wide significance geographical regions GISAID GISAID database GWAS highly pathogenic host susceptibility identify improvement Improvements in viral information loci locus Logistic Logistic regression methodology Mortality Mutation occur p value p values P.1 pathogenic pathogenicity remained risk S2 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 spike protein sequence variation sequenced single-stranded Spike protein starting strain submitted symptom severity target host cells the SARS-CoV-2 the SARS-CoV-2 genome variant viral entry viral genome viral infectivity viral strain virus WGS whole-genome sequencing [DOI] 10.1002/gepi.22421 PMC 바로가기 [Article Type] Article
Education as a Predictor Factor for Knowledge of COVID-19 in PortugalPublic Health Published on 2021-09-292022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] approved communication Community COVID-19 cross-sectional demonstrated disease domain education Effect Factor functional Future Health health knowledge health literacy IMPROVE include independent variable index information Intervention material mechanism median age Medical Sciences Multivariate analysis pandemic platform Portugal positive predictor preventive measure preventive measures promote public health risk factor subject submitted were assessed women [DOI] 10.3389/fpubh.2021.680726 PMC 바로가기 [Article Type] Public Health
Design, validation and implementation of the post-acute (long) COVID-19 quality of life (PAC-19QoL) instrumentObservational Study Published on 2021-09-282022-10-04 Journal: Health and Quality of Life Outcomes [Category] SARS, 임상, [키워드] affected Antibody test clinical study control group COVID COVID-19 diagnosed with COVID-19 diagnostic disease Disease progression domains Evidence global pandemic healthy Identifier identify implementation Indicator Infection life Novel coronavirus outcome measure participant Patient physical prospective observational cohort Psychological public health Quality Quality of life research methods Result resulting SARS-CoV-2 score statistically significant difference Statistics submitted suffered the disease the mean Treatment two groups upper respiratory tract was used [DOI] 10.1186/s12955-021-01862-1 PMC 바로가기 [Article Type] Observational Study
Assessment of pancreatitis associated with tocilizumab use using the United States Food and Drug Administration Adverse Event Reporting System databaseArticle Published on 2021-09-222022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] 95% CI 95% confidence interval Adverse adverse effects adverse event assessment Concomitant medication criteria Data mining database determine disorders drug drug therapy drugs events Evidence food information likelihood limit Occurrence Odds ratio pancreatic pancreatic disease Patient receiving remained Reporting Rheumatic diseases rheumatoid arthritis study period submitted System systemic inflammatory TCZ the United State Tocilizumab treat two-sided [DOI] 10.1038/s41598-021-98325-w PMC 바로가기 [Article Type] Article
The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settingsInfectious Diseases Published on 2021-09-172022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, SARS, [키워드] adjusted Administered Analysis approved association baseline change Cohort confounders COVID-19 COVID-19 pandemic dissemination distress Ethics Ethnic groups Ethnicity Evidence Follow-up generalisability group groups HCW HCWs Health Health Research Authority healthcare healthcare worker Healthcare workers increased risk information large-scale analysis longitudinal cohort study mental health morbidity and mortality National outcome outcomes physical protocol public health question questionnaire questionnaire data Registered Result risk stratified submitted Support tested United Kingdom variable variables [DOI] 10.1136/bmjopen-2021-050647 PMC 바로가기 [Article Type] Infectious Diseases
Pre-evaluation assessment of serological-based COVID-19 point-of-care lateral flow assays in KenyaOriginal Research Published on 2021-09-172022-10-28 Journal: African Journal of Laboratory Medicine [Category] COVID-19, [키워드] Asymptomatic authorisation board China collected coronavirus disease COVID-19 COVID-19 testing detect Emergency use IgG IgM IgM and IgG Immunity intensity Kenya lateral flow management national regulatory authority nine objective outcome Pharmacy plasma sample point-of-care point-of-care test Poison polymerase chain ranged Result reverse transcription SARS-CoV-2 sensitivity serological specificity submitted Support turn were used [DOI] 10.4102/ajlm.v10i1.1317 PMC 바로가기 [Article Type] Original Research
Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant RecipientsOncology Published on 2021-09-062022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] administration Against Allogeneic allogeneic HSCT Antibody Response Antibody titer autologous autologous HSCT B cell B lymphocyte BNT162b2 CD19 CD19+ CD20 CD56+ Cell control group correlated correlation COVID-19 immunity cyclosporine Cytometry develop Efficacy evaluate Flow glycoprotein healthy subjects HSCT HSCT recipients immune response immunosuppressive Impaired mRNA-based natural killer negatively affected NK cell NK cells Patient performed Peripheral blood Pfizer-BioNTech platform Prospective Study recipient response rituximab SARS-CoV-2 IgG SARS-CoV-2 vaccine SARS-CoV2 second dose Seroconversion serum sample STEM Stem cell transplantation submitted T cells tested the antibody response the Spike Transplant vaccination Vaccine [DOI] 10.3389/fonc.2021.737300 PMC 바로가기 [Article Type] Oncology
The effect of framing and communicating COVID-19 vaccine side-effect risks on vaccine intentions for adults in the UK and the USA: A structured summary of a study protocol for a randomized controlled trial영국과 미국의 성인을 위한 백신 의도에 대한 COVID-19 백신 부작용 위험을 구성하고 전달하는 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-062022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] age Algorithm American anonymously Arm ARMS balanced randomization Behavior behavioral science blinded Blinding blood clot Blood clots can not categories category cause clinical communication comparison Comparisons Complete conducted country COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 vaccine described determine develop died dimension dissemination effort element eligible English evaluate evaluate the effect Evidence excluded expected experiment experimental arm experimental evidence explain Factor factorial design factorial designs female Final FIVE fixed Gorilla group Group allocation Host hygiene hypothetical Impact inclusion criteria Independence independent independent of individual individuals influence information Intention Interaction Intervention intervention group investigator investigators London male media Medicine Mortality motor vehicle number objective outcome outcome measure outcome measures participant Participants platform portion potentially life-threatening Primary outcome Probability Prolific proportion protocol public healthinternet-based studies, protocol Qualitative question questionnaire randomization randomize Randomized Randomized controlled trial randomizing Randomly receive recruit Registered replacement reported researcher respond response risk Risk communication risk of COVID-19 Safe School secondary outcome Sex Side effect Side effects Side-effect Sociodemographic Study protocol submitted subset supplementary material text the vaccine Trial registration tropical medicine unlikely USA vaccinated individual vaccination vaccination rates Vaccine Vaccine hesitancy vaccine intention vaccine intentions website widespread [DOI] 10.1186/s13063-021-05484-2 PMC 바로가기 [Article Type] Letter
Incidence, severity and perceived susceptibility of COVID-19 in the UK CrossFit populationResearch Published on 2021-09-062022-10-27 Journal: BMC Sports Science, Medicine and Rehabilitation [Category] COVID-19, [키워드] age analysed Analysis asked BMI body height body mass body mass index coded collected data conducted Contemporary literature correlated COVID-19 COVID-19 infection COVID-19 severity COVID-19 susceptibility criteria cross-sectional CrossFit CrossFit™ disease disease severity female Final Functional exercise Gender greater Health host immunity impacted indicate individual infected with COVID-19 Kruskal–Wallis lockdown male metabolic disease no significant difference obese participant physical activity Probability ranged reduced reported Result risk factor severity severity of COVID-19 Sex shown significant difference subgroup submitted susceptibility WHO [DOI] 10.1186/s13102-021-00318-9 PMC 바로가기 [Article Type] Research
Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the WorldResearch article Published on 2021-09-012022-10-05 Journal: JACC. Cardiovascular imaging [Category] SARS, 진단, [키워드] affected association baseline Cardiology cardiovascular cardiovascular disease cardiovascular imaging Care coronavirus country COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 testing CVD Decline diagnostic diagnostic cardiovascular procedure early phase effort energy Factor greater illnesses Impact implication invasive laboratory characteristics maintain measure morbidity and mortality multivariable analysis Non-COVID-19 objective outbreak pandemic Patient Prevalence reduced reduction reduction in reductions in Region regions reported Result screenings South submitted Symptom temperature Testing the United State The United States Variability Volume West [DOI] 10.1016/j.jcmg.2021.03.007 [Article Type] Research article