Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans인간의 SARS-CoV-2 감염에 대한 중화 항체 반응의 동역학 및 상관 관계Article Published on 2021-06-092022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, 치료기술, [키워드] age antibody antibody kinetics Antibody Response broad spectrum correlates of neutralization COVID-19 COVID-19 pandemic Critical cross-neutralizing demonstrated disease severity evaluated exceptional exhibiting Gender half-live half-lives Human IgG IgG antibody individual individuals Infection initial key factor Kinetics longitudinal cohort Mild multivariate neutralization Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing antibody response purified reactivity SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2-neutralizing antibody serum Spike protein statistical sustained symptomatic infection understanding Vaccination strategies virus spike protein [DOI] 10.1016/j.chom.2021.04.015 PMC 바로가기 [Article Type] Article
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios산모 및 신생아 제대혈 SARS-CoV-2 항체 및 태반 전달 비율 평가Article Published on 2021-06-012022-09-11 Journal: JAMA Pediatrics [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed antibody antibody concentration Antibody concentrations Antibody Response antibody transfer Asian assessment association Asymptomatic black Blood blood specimen Clinical data cohort study Combination Concentration CORD Cord blood coronavirus coronavirus disease Coronavirus disease 2019 correlated Demographic and clinical data during pregnancy enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Hispanic IgG IgG antibody IgM IgM antibodies IgM antibody Immunity Infant Infants Infection interquartile range management Maternal maternal antibody median Mild moderate mother Neonatal Newborn outcome parturient Philadelphia Placenta positively correlated Pregnancy Ratio receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody SARS-CoV-2 spike protein sera seronegative seropositive severe acute respiratory syndrome Coronavirus severe coronavirus disease significantly lower specimen Spike protein study cohort subsequent symptomatic infection the receptor-binding domain the SARS-CoV-2 time of delivery took place transfer transferred understanding Vaccination strategies were measured white women [DOI] 10.1001/jamapediatrics.2021.0038 PMC 바로가기 [Article Type] Article
Effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 infection and hospitalisation, Navarre, Spain, January to April 2021Rapid Communication Published on 2021-05-272022-10-31 Journal: Eurosurveillance [Category] COVID-19, SARS, [키워드] close contact cohort study Complete COVID-19 COVID-19 hospitalisation COVID-19 vaccine diagnosed dose Effectiveness evaluated finding hospitalisation hospitalisations infections SARS-CoV-2 SARS-COV-2 infection second dose significantly increased Spain Support symptomatic symptomatic infection vaccination Vaccine vaccine effectiveness [DOI] 10.2807/1560-7917.ES.2021.26.21.2100438 PMC 바로가기 [Article Type] Rapid Communication
Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data이스라엘의 전국적인 예방접종 캠페인에 따른 SARS-CoV-2 감염 및 COVID-19 사례, 입원 및 사망에 대한 mRNA BNT162b2 백신의 영향 및 효과: 국가 감시 데이터를 사용한 관찰 연구Observational Study Published on 2021-05-152022-09-11 Journal: Lancet (London, England) [Category] Fulltext, SARS, 변종, 임상, [키워드] 95% CI adjusted age all age group all age groups Analysis Asymptomatic asymptomatic infection authorisation B.1.1.7 B.1.1.7 SARS-CoV-2 variant B.1.1.7 variant BNT162b2 calculated caused Coverage COVID-19 COVID-19 cases COVID-19 vaccination COVID-19 vaccine COVID-19-related death Critical death Decline declined defined dose effective Effectiveness Emergency use estimate evaluate help hospitalisation hospitalisations Impact incidence incidence rate incidence rates individual International laboratory-confirmed SARS-CoV-2 infection Ministry of Health MoH mRNA mRNA BNT162b2 vaccine National non-proprietary name of BNT162b2 Older outcome outcomes pandemic PCR test Pfizer-BioNTech Prevalence prevelance proportion receiving Regression model SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-positive specimen second dose second dose of vaccine severe disease Sex spike gene surveillance data sustained symptomatic symptomatic and asymptomatic symptomatic COVID-19 symptomatic infection tested the vaccine vaccinated individual vaccinated individuals vaccination Vaccine was used widespread [DOI] 10.1016/S0140-6736(21)00947-8 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 antibody seroprevalence in NHS healthcare workers in a large double-sited UK hospital영국 대형 병원 NHS 의료 종사자의 SARS-CoV-2 항체 혈청 유병률Article Published on 2021-05-012022-09-12 Journal: Clinical medicine (London, England) [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval age antibody Asymptomatic individuals coronavirus COVID-19 cross-sectional determinant HCW HCWs healthcare healthcare worker Healthcare workers hospital independent individual NHS NHS staff Odds ratio regression analysis Sample size SARS-CoV-2 SARS-CoV-2 antibody seropositive Seroprevalence Seven Sex significantly more symptomatic symptomatic infection Symptoms white women [DOI] 10.7861/clinmed.2020-1096 PMC 바로가기 [Article Type] Article
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection강력한 SARS-CoV-2-특이 T 세포 면역은 1차 감염 후 6개월 동안 유지됩니다.Article Published on 2021-05-012022-09-12 Journal: Nature Immunology [Category] Fulltext, SARS, 진단, [키워드] Analysis analyzed antibody CD4 cellular immunity characterized correlated correlation Critical cytokine expression disease Donor functional immune response Immunity Infection intracellular cytokine staining magnitude phenotype predominant Primary infection Protein Reinfection responses retained SARS-CoV-2 severity symptomatic infection T cell T cell response waning immunity [DOI] 10.1038/s41590-021-00902-8 PMC 바로가기 [Article Type] Article
Cigarette Smoke Exposure, Pediatric Lung Disease, and COVID-19Physiology Published on 2021-04-272022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome addition Adults Affect ARDS Asthma caused children children’s health chronic respiratory diseases cigarette cigarette smoke exposure complications contrary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case CSE death detrimental effect develop disease disorders E-cigarette Effect elevated exposure highlight Hospitalization incline Infant infected with SARS-CoV-2 Infection Inflammation Inflammatory likelihood lung Manifestations mechanical ventilation Mild outcome oxygen pediatric Population Premature Prevalence public health respiratory symptom risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe COVID-19 significantly smoke smoking spectrum of disease Spread susceptibility symptomatic infection syndrome vaping virus wheezing [DOI] 10.3389/fphys.2021.652198 PMC 바로가기 [Article Type] Physiology
Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infectionsSARS-CoV-2 감염 감지를 위한 다양한 빈도의 일상적인 무증상 PCR 검사의 효과 추정Research Article Published on 2021-04-272022-09-01 Journal: BMC Medicine [Category] MERS, 진단, [키워드] Asymptomatic Asymptomatic case Asymptomatic cases asymptomatic infection Bayesian Care Course COVID-19 dataset detect Effectiveness estimates Frequency healthcare worker Healthcare workers help hospital infected individual infected individuals Infection medical staff Nasopharyngeal swab notification outbreak PCR PCR test PCR testing peaked performed populations positive PCR test Presymptomatic infections Prevent Probability proportion provided Result returned routine RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity statistical model supplementary material symptom onset symptomatic case symptomatic cases symptomatic infection Symptoms test results Test sensitivity twice weekly Vulnerable populations [DOI] 10.1186/s12916-021-01982-x PMC 바로가기 [Article Type] Research Article
School closures reduced social mixing of children during COVID-19 with implications for transmission risk and school reopening policiesLife Sciences–Mathematics interface Published on 2021-04-142022-10-30 Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS, SARS, [키워드] Area assumption Bay children Children social networks Cohort collected data Community community transmission Contact Contact rate COVID-19 COVID-19 incidence Effectiveness expected had more Hispanic implication Infectious disease Intervention K–12 measure moderate Precaution reduce reduced risk SARS-CoV-2 School school closures and reopening social contact social distancing social interaction symptomatic symptomatic infection Transmission Transmission model transmissions [DOI] 10.1098/rsif.2020.0970 PMC 바로가기 [Article Type] Life Sciences–Mathematics interface
A renewal equation model to assess roles and limitations of contact tracing for disease outbreak controlMathematics Published on 2021-04-072022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] applied calculate Characteristics Combination community transmission Contact tracing Coverage COVID-19 deterministic model Diagnosis disease effective feature growth implementation incidence individual level infected individual Infection Infectious disease Intervention limitation measure mitigate Non-pharmaceutical interventions outbreak pathogen Prevalence Probability public health reduce renewal equation Reproduction number resource constraints SARS-CoV-2 symptomatic infection the epidemic time since infection Transmission dynamics [DOI] 10.1098/rsos.202091 PMC 바로가기 [Article Type] Mathematics