Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data게놈 전체 일배체형 데이터에서 인간의 후보 생식계열 돌연변이 유전자좌의 추론Research Article Published on 2017-01-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1000 Genome 1000 Genomes 1000 Genomes Project affected allele alleles base bases BRSK2 candidate Cell characterized cohorts de novo mutation de novo mutations DNA damage DNA repair elevated error expressed genetic loci Genetic variation Genome genome sequence genomic region germline Haplotype haplotypes Human human diseases Human genomes human population human populations identify incorporation increase individual Inference involved lead loci locus Mutation mutation rate Netherland occur offspring parent parents Phase 3 proportion remained replicated reported resulting searched species spontaneous mutations Support Testis thought upstream Variation [DOI] 10.1371/journal.pgen.1006549 PMC 바로가기 [Article Type] Research Article
Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis곰팡이 약물 내성 및 형태 형성을 제어하는 세포 회로를 조사하기 위한 강력한 전략으로서의 금속 킬레이트화Research Article Published on 2016-10-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation Affect Analysis Antifungal approach approaches Candida albican Candida albicans candidiasis caspofungin cell wall Cellular responses chelation Combination Compound demonstrated depleting Depletion drug drug resistance DTPA echinocandin effective Efficacy ENhance environmental cues fungal fungal cell wall Fungal infection fungal infections fungal pathogens gene encoding Genome sequencing Health histidine homeostasis identify increase Infectious disease inhibitor invasive lead library life-threatening Magnesium mechanism metal mitogen mitogen-activated protein kinase modulate morphogenesis mouse model murine model mutant mutants Mutation pathogen Pathogenesis Pathogens pathway Protein protein kinase reduce regulated resistance screened Sequencing Signaling Strategy Stress stress response susceptibility synergistic therapeutic Therapeutic benefit therapeutic benefits therapeutic potential therapeutic strategy Therapeutics transcription factor transcription factors upstream virulence Whole genome sequencing Zinc [DOI] 10.1371/journal.pgen.1006350 PMC 바로가기 [Article Type] Research Article
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β PathwayResearch Article Published on 2016-08-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activated caused cellular pathway downstream effector epidemic diarrhea function high mortality Infection inhibiting intracellular signaling late stage pathway Pathways PEDV phosphatidylinositol 3-kinase PI3K regulated Replication required shown signaling pathway subsequent suppression upstream Vero Cell Vero cells viral infection virus virus replication [DOI] 10.1371/journal.pone.0161508 PMC 바로가기 [Article Type] Research Article
The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cellsResearch Paper: Immunology Published on 2016-03-152022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] Actin activating binding cascade cause cell membrane cofilin coronavirus decrease diarrhea disrupt downstream EGFR epidermal F-actin gastroenteritis growth factor GTPases high mortality Host immune response Immunity Immunology and Microbiology Section Infection inhibit inhibition intestinal epithelial cell intestinal epithelium involved MAPK mechanism Newborn Pathogenesis Phosphorylation PI3K platform promote Protein receptor regulate responsible Signaling signaling pathway Spike protein stimulate TGEV transmissible gastroenteritis virus upstream virus entry [DOI] 10.18632/oncotarget.7723 PMC 바로가기 [Article Type] Research Paper: Immunology
High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome ProfilingResearch Article Published on 2016-02-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed [DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article
A general strategy to inhibiting viral −1 frameshifting based on upstream attenuation duplex formationMolecular Biology Published on 2016-01-082022-10-31 Journal: Nucleic Acids Research [Category] Coronavirus, [키워드] annealing antiviral target approach attenuate combating complementary coronavirus Coronaviruses downregulate downstream efficient Epidemic eukaryotic HIV Human immunodeficiency virus indicate information inhibiting mechanism MERS-CoV Middle East mRNA provide proximal respiratory syndrome coronavirus responsible RNA robust sequence sequence information shown stimulated upstream viral pathogen viral pathogens [DOI] 10.1093/nar/gkv1307 PMC 바로가기 [Article Type] Molecular Biology
First complete genome sequence of European turkey coronavirus suggests complex recombination history related with US turkey and guinea fowl coronavirusesStandard Published on 2016-01-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] Analysis backbone Complete complex coronavirus Coronaviruses defined European event French full-length genome Genes Genetic genome sequence IBV Infectious Bronchitis Virus Italy North ORF Pathways predicted Recombination Region S gene sequence shown supported unique upstream virus viruses was determined [DOI] 10.1099/jgv.0.000338 PMC 바로가기 [Article Type] Standard
Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014Expedited Published on 2015-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Admission Affect age cause clinical outcomes Clinical severity cycle threshold death decrease determine died E gene evaluated intensive care load median MERS-CoV Middle East Middle East respiratory syndrome Coronavirus modulation multivariable nasopharyngeal specimen outcome Patient patients positive Regression analyses respiratory syndrome coronavirus Result reverse transcription PCR risk factor Saudi Arabia significantly lower survivor tested the median therapeutic agent upstream virus virus load viruses zoonoses [DOI] 10.3201/eid2111.150764 PMC 바로가기 [Article Type] Expedited
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathwayResearch Published on 2015-08-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation adapter African green monkey antiviral immune response blockade blocked cell line damaged demonstrated digestive disorders epidemic diarrhea epithelial cell expression Host identify IFN IFN-β immune cell population immune function in vitro in vivo induce Infection inhibit inhibited inhibitor of κB innate immune system Interaction interferon Intervention intestinal epithelia intestinal epithelial cell intestinal epithelial cells investigated kidney kinase-ε lack Limited mechanism molecular mechanism NF-κB nuclear offered Pathogenesis pathway PEDV promoter Regulatory Result RIG-I signaling pathway target cell transcription factors Type type I interferon upstream Vero Cell virus were used [DOI] 10.1186/s12985-015-0345-x PMC 바로가기 [Article Type] Research