Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, [키워드] biallelic children Clinical research Cohort develop developmental effective Efficacy and safety enrolled expected Final highlighting Infant investigator multicenter muscular Mutation Neuromuscular Newborn phase presymptomatic Respiratory Support risk Serious Adverse Event single-arm study SMN1 SMN2 survived treated Treatment Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01866-4 [Article Type] Research
SARS-CoV-2: phenotype, genotype, and characterization of different variantsSARS-CoV-2: 다양한 변이체의 표현형, 유전자형 및 특성화Article Published on 2022-06-172022-09-11 Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha Amino acid amino acid sequence angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibiotics antiviral drugs B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 B.1.621 Beta can not Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta domain eliminated envelope epidemiological data exceptional family Coronaviridae Gamma Genetic variation Genome Genotype Glucocorticoids Health Organization help host cells IFN-α2b Immunoglobulin include infect Infection international public health Intravenous immunoglobulin Lambda membrane Nidovirales nucleocapsid omicron P.1 patients phenotype plasma plasma therapy positive Prevent Protein receptor risk of infection RNA RNA virus SARS-CoV-2 SARS-CoV-2 variants Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread structural protein structural proteins subtype the Coronaviridae therapy Transmission treat vaccination Vaccine variant Variation variations VoC WHO World Health Organization [DOI] 10.1186/s11658-022-00352-6 PMC 바로가기 [Article Type] Article
Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods임신 및 산후 기간에 코로나바이러스 질병 2019(COVID-19)를 설명하기 위한 순차적, 전향적 메타 분석을 위한 프로토콜Article Published on 2022-06-162022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] Adolescent age aggregate Analysis approach best Child contribute coronavirus disease country COVID-19 epidemiological estimates generate group Health health facilities Health Organization include investigator investigators knowledge Local Maternal meta-analyses Meta-analysis National outcomes pandemic patient data PMA pregnancies Pregnancy pregnant primary analysis protocols question reproductive Research Result SARS-COV-2 infection steering committee systematic review These data threshold while WHO with COVID-19 women working World Health Organization [DOI] 10.1371/journal.pone.0270150 PMC 바로가기 [Article Type] Article
Does the rubella immunoglobulin G affect the severity of COVID- 19? : Rubella immunoglobulin G and COVID- 19풍진 면역글로불린 G가 COVID-19의 중증도에 영향을 줍니까? : 풍진 면역글로불린 G와 코로나19Article Published on 2022-06-112022-09-12 Journal: BMC Microbiology [Category] MERS, 진단, [키워드] Affect age conducted coronavirus disease correlation COVID COVID-19 COVID-19 confirmed patient COVID-19 disease severity COVID-19 severity COVID-19 vaccination Critical determine disease severity ELISA enzyme-linked immunosorbent extrinsic fatality Guidance Hospitalization IgG IgG antibody titer Immunity Immunoglobulin Immunoglobulin G Infection Inpatient Interaction Iran Mild moderate National negative correlation objective positive reducing rubella severity the disease vaccination was measured WHO [DOI] 10.1186/s12866-022-02563-5 PMC 바로가기 [Article Type] Article
Study protocol: cohort event monitoring for safety signal detection after vaccination with COVID-19 vaccines in Iran연구 프로토콜: 이란에서 COVID-19 백신 접종 후 안전 신호 감지를 위한 코호트 이벤트 모니터링Article Published on 2022-06-092022-09-11 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] approved articles AZD1222 BBIBP-CorV clinical trial clinical trials Cohort Cohort profile Complete continuous monitoring COVID-19 COVID-19 disease COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Data collection dose enrolled expansion follow-up period Health Organization Hospitalization implementation include investigated Iran National New Other outcome participant prospective cohort study protocol provided reactogenicity receive required Safety second dose Seven Sinopharm study outcome study outcomes Surveillance target population Template the vaccine vaccination Vaccine Vaccines WHO with COVID-19 World Health Organization [DOI] 10.1186/s12889-022-13575-1 PMC 바로가기 [Article Type] Article
Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trialClinical Trial Published on 2022-06-072022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI administration Adverse age Antigen assigned AstraZeneca block sizes blocked clinical clinical evaluation clinically collected conducted Course COVID-19 COVID-19 vaccination death dose double-blind Efficacy enrolled enrolment Europe evaluate event Fever finding for inclusion funding individual intramuscular intramuscular injections investigators involved Japan laboratory-confirmed SARS-CoV-2 infection Latin America less Mild moderate Moderate COVID-19 monoclonal antibody combination non-hospitalised occurred Older outcomes participant Phase 3 Placebo placebo-controlled study placebo-controlled trial prevent disease progression primary endpoint progression provided randomisation randomised Randomly receive Registered required respiratory tract risk reduction RT-PCR scale severe COVID-19 severity specimen Sponsor statistically stratified study drug Symptom symptom onset the disease the placebo group treating Treatment treatment group USA WHO [DOI] 10.1016/S2213-2600(22)00180-1 [Article Type] Clinical Trial
The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant고도로 돌연변이된 SARS-CoV-2 오미크론 변종의 출현 및 전염병 특성Review Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid B.1.1.529 Beta Characteristics coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 defined Delta delta variant dominant Epidemic Gamma Genome group Health Organization Immune escape information mutated Mutation mutations omicron Omicron variant reactivity reported SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus shown Spike protein strain the epidemic the spike protein the WHO type strain Vaccine Vaccine development variant VoC VOCs WHO wild-type strain World Health Organization [DOI] 10.1002/jmv.27643 PMC 바로가기 [Article Type] Review
Body mass index and its association with COVID-19 clinical outcomes: Findings from the Philippine CORONA studyResearch article Published on 2022-06-012022-10-05 Journal: Clinical nutrition ESPEN [Category] 바이오마커, [키워드] abnormality Admission adverse outcome Analysis analyzed Asia-Pacific association being BMI body mass body mass index coronavirus disease correlated COVID-19 COVID-19 admission criteria Cutoff finding group IMV in-hospital mortality independent intensive care Invasive mechanical ventilation investigated large cohort multicenter neurologic neurological obesity outcome outcomes Patient Primary outcome Result retrospective cohort study risk SARS-CoV-2 shown underweight WHO with COVID-19 [DOI] 10.1016/j.clnesp.2022.03.013 [Article Type] Research article
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Game of transmissions (GoT) of SARS-CoV-2: Second wave of COVID-19 is here in IndiaReview article Published on 2022-06-012022-10-05 Journal: Current Opinion in Environmental Science & Health [Category] 변종, [키워드] Airborne transmission caused concerning Corona virus coronavirus 2 COVID-19 disease game globe India infectious agent information investigated knowledge MOST organization pandemic pathway Precision provided Rapid respiratory SARS-CoV-2 SARS-CoV-2 transmission second second wave selective Spread temporal variation trajectory Transmission transmission pathway transmissions virus WBE while WHO World Health Organization Worldwide WWTPs [DOI] 10.1016/j.coesh.2022.100355 [Article Type] Review article