susceptibility – Page 138 – Communicable Diseases Research

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Exhibits High Predicted Binding Affinity to ACE2 from Lagomorphs (Rabbits and Pikas)

Communication

Published on 2020-08-202022-10-28
Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19,

Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2

Medicine

Published on 2020-08-192022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 95% CI 95% confidence interval ACE2 ACE2 expression ACE2 mRNA ACE2 protein age analyzed angiotensin covering enzyme II angiotensin-converting enzyme 2 association Blood Cancer cellular entry receptor clinical Clinical characteristics Coronavirus disease 2019 correlation COVID-19 demographic diabetes disease ELISA assay enrolled expression Factor female female subject females form Gender higher risk hypertension identify increased risk individual Infection linear Linear regression analysis Logistic regression analysis male Multiple Multiple linear regression Odds ratio Older age older subjects Pearson performed polymerase chain questionnaire regression analysis reported SARS-CoV-2 Smokers smoking Spread statistically significant student subject subjects susceptibility susceptible t -test was used Wuhan, China
[DOI] 10.3389/fmed.2020.00530 PMC 바로가기 [Article Type] Medicine

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

4,4′-다이아미노디페닐 설폰(DDS) 염증소체 경쟁자로서

Article

Published on 2020-08-192022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, 한센병,

[키워드] 4,4′-diaminodiphenyl sulfone (dapsone) Activation AD Alter Alzheimer’s disease Alzheimer’s disease Antibiotics binding caspase-1 cause cleaved Cognitive impairment Combination DDS demonstrated diagnosed Diseases effective Effects Factor Fever fibrosis genetic polymorphisms Hansen’s disease human disease immune response implicated Inflammasome inflammasomes intracellular domain involved Korean lepromatous leprosy (also known as Hansen’s disease) leprosy ligands LL Lung inflammation MADDS mechanism microbial Mild molecular monoacetyldapsone MPO Mutation myeloperoxidase NACHT, LRR and PYD domains-containing protein 3 NLRP3 NLRP3 inflammasome Parkinson’s disease Patient protein 3 receptor Regulation reported responsible S protein SARS-CoV SARS-CoV-2 Sulfone susceptibility tested TLR TLR2 TLRs Toll-like receptor treated Treatment type 2 diabetes variety viruses zoonotic
[DOI] 10.3390/ijms21175953 PMC 바로가기 [Article Type] Article

Susceptibility of the Iranian population to severe acute respiratory syndrome coronavirus 2 infection based on variants of angiotensin I converting enzyme 2

Research Article

Published on 2020-08-172022-10-31
Journal: Future Virology [Category] COVID-19,

Association between ABO blood groups and risk of coronavirus disease 2019 A protocol for systematic review and meta-analysis

4900

Published on 2020-08-142022-10-30
Journal: Medicine [Category] COVID-19, MERS,

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

Immunology

Published on 2020-08-112022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Adverse anti-viral activity antibodies approach co-morbidities coronavirus disease COVID-19 Critical damaged tissue deficiency drive driven by Effect environmental exposure Evidence exacerbate exacerbated fatty acids highlight identify immunosuppressive independent risk factor induce Infection Inflammation influenza infection lipoxins maresins mediator metabolic factor metabolite morbidity and mortality obesity overcome pandemic pharmacological interventions Polyunsaturated promote protectins pulmonary inflammation resolvins respiratory responsible SARS-CoV-2 SARS-COV-2 infection susceptibility tissues
[DOI] 10.3389/fimmu.2020.01997 PMC 바로가기 [Article Type] Immunology

A human circulating immune cell landscape in aging and COVID-19

Research Article

Published on 2020-08-112022-10-29
Journal: Protein & Cell [Category] COVID-19, MERS, SARS,

Preliminary Post-Mortem COVID-19 Evidence of Endothelial Injury and Factor VIII Hyperexpression

Article

Published on 2020-08-092022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] ACE2 acute respiratory distress all subject antibody ARDS Autopsy Biomarker cellular Complete concerning COVID-19 COVID-19 diagnostic COVID-19 infection cytokine expression death diagnosing Diagnosis died Diffuse alveolar damage effort endothelial damage evidence of expressed factor VIII forensic pathology forensic science form FVIII histological Hypothesis immunohistochemistry Infection interstitial pneumonia lung Newborn outbreak pandemic pathology performed Pneumonia Post-mortem post-mortem examination public health Research severity specimens Surveillance Survivors susceptibility syndrome two subject Vascular vascular disease viral pathogenesis widespread
[DOI] 10.3390/diagnostics10080575 PMC 바로가기 [Article Type] Article

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Report

Published on 2020-08-072022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS,

[키워드] aberrant immune response acute respiratory syndrome airway Antiviral antiviral immunity bacterial superinfections cause characterized Clinical practice contribute coronavirus coronavirus disease COVID-19 COVID-19 patient Critical critical COVID-19 patient dendritic cell disrupt driving elicit Endemic engage ENhance epithelial Evidence expressed expression functions IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs Immune cell immunopathology increase indicate induce Infection influenza infection Influenza virus inhibiting interfere ISGs Local Lower respiratory tract lung lung epithelial lung epithelium Major mice morbidity Mortality Mounting mucosal surface Necrosis p53 parameter Pathogenesis pathophysiological Patient Peripheral blood produced proinflammatory proliferation respiratory viral infections response responses RNA viruses SARS-CoV-2 Science secreted Severe case severity susceptibility therapeutic thought Transcription Trigger turn Type type I Type I IFN Type III IFN type III interferon viral burden viral infections viral respiratory disease viral respiratory infections Viral RNA viruses
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Report

Published on 2020-08-072022-10-06
Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단,

[키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA
[DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report