Building a Research Roadmap for Caregiver Innovation: Findings from a Multi-Stakeholder Consultation and EvaluationArticle Published on 2021-11-232022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] accelerate analysed approach building Care Caregiver Caregivers Co-design collaboration at distance collected Community consultation convenience sampling COVID-19 pandemic develop Digital health events finding first stage group Health help identify Innovation Interdisciplinary intervene participatory design predominant professional Quality of life Quantitative recommendation Research response Support supported thematic analysis [DOI] 10.3390/ijerph182312291 PMC 바로가기 [Article Type] Article
Metabolic health, menopause, and physical activity—a 4-year follow-up studyArticle Published on 2021-11-202022-10-04 Journal: International journal of obesity (2005) [Category] 바이오마커, [키워드] 95% CI accelerate Adiposity baseline Biomarker blood glucose blood lipid blood pressure body composition carried changes changes in cholesterol DBP deteriorate diastolic evaluate Fat mass Follow-up follow-up study follow-up time group HDL-C Health LDL-C linear lipoprotein cholesterol longitudinal low-density menopausal metabolic metabolic syndrome modulate participant physical physical activity Poisson Questionnaires Result Risk factors SBP serum timepoints triglycerides variables Waist circumference was used WHR women [DOI] 10.1038/s41366-021-01022-x PMC 바로가기 [Article Type] Article
Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent NeurodegenerationCase Report Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] accelerate accelerated neurodegeneration aging clinical Clinical deterioration COVID-19 Creutzfeldt–Jakob disease Creutzfeldt–Jakob disease disease Effect effort Evidence exhibited female Host immune response infection with SARS-CoV-2 Inflammation neurodegeneration neurodegenerative neurological outcome Pathogenesis Patient progression radiological SARS-CoV-2 SARS-COV-2 infection Seizure severe COVID-19 systemic the disease viral infection [DOI] 10.3390/biomedicines9111730 PMC 바로가기 [Article Type] Case Report
Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies2개의 비경구 투여 SARS-CoV-2 중화 항체의 조합을 사용하여 붉은털 원숭이에서 COVID-19의 효과적인 예방Cellular and Infection Microbiology Published on 2021-11-182022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] accelerate added Administered administration anti-SARS-CoV-2 antibody combination benefit beta coronavirus block blocking clinical study Cohort Combination combination treatment Complete COVID-19 disease dose effective evidenced immunoprophylaxis Infection lack lower dose mAb macaque monoclonal antibody mucosal neutralize nonhuman primates parenteral administration pathogenic pathologic pathology pharmacokinetics prophylactically Protective receiving Result rhesus SARS-CoV-2 SARS-CoV-2 antibodies subset swabs tissue viral challenge viral infection virus Virus neutralization worldwide pandemic [DOI] 10.3389/fcimb.2021.753444 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case ReportMedicine Published on 2021-11-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accelerate acute respiratory distress administration ARDS Case report CD4+ Cell cell population Cell therapy chest CT scan classical Clinical deterioration clinical trial consolidation CORD coronavirus disease COVID-19 Critically ill Critically ill patient decrease dendritic cell discharged dose Effect Efficacy fatality fibrosis Frequency ICU Ill immunomodulation increase in Inflammation inflammatory monocyte infusion intensive care intubation Invasive mechanical ventilation invasive ventilation Lung fibrosis Lung inflammation Lymphocytes male mechanical ventilation mechanically ventilated mesenchymal stromal cells (MSCs) Monocytes MSC MSC therapy PaO Patient patient with COVID-19 Peripheral blood presenting Prognosis reduced reduction reduction in report reported Serious Adverse Event severe lung inflammation stromal cell symptoms onset syndrome therapy tracheal treated vasoactive drug with COVID-19 worsening [DOI] 10.3389/fmed.2021.767291 PMC 바로가기 [Article Type] Medicine
Animal models for SARS‐CoV‐2 infection and pathologyReview Published on 2021-11-162022-10-30 Journal: MedComm [Category] COVID-19, [키워드] accelerate acute respiratory syndrome Analysis animal animal model animal models antiviral drug Appropriate Beta Care Characteristics coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 current Delta etiology ferrets Gamma hamsters Health immune response immunology immunomodulatory Infection Lambda mice pandemic Pathogenesis pathology platform provided robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 therapeutic agents therapeutic drug therapy Transmission Vaccine Vaccines variant [DOI] 10.1002/mco2.98 PMC 바로가기 [Article Type] Review
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammationArticle Published on 2021-11-152022-10-04 Journal: Nature Communications [Category] 변종, [키워드] accelerate accompany activate activating Alzheimer's disease binding Brain cDNA Cognitive impairment disease extrinsic Genes HIV Human immunodeficiency virus in vitro in vivo induce Inflammation innate immune response Innate immunity Interaction interferon mechanism microglia microglial neurodegeneration neurodegenerative neurodegenerative disorders Neuroimmunology NFκB nuclear nuclear translocation pathway PQBP1 primary culture promote Protein receptor resulting Transcription Trigger virus infection [DOI] 10.1038/s41467-021-26851-2 PMC 바로가기 [Article Type] Article
The Effect of the COVID-19 Vaccine on Daily Cases and Deaths Based on Global Vaccine DataArticle Published on 2021-11-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate Administered association calculate caused collected conducted confirmed case Coronavirus disease 2019 correlation country COVID-19 COVID-19 case COVID-19 cases COVID-19 deaths Daily death distribution dose doses Effect global pandemic Meta-analysis pandemic per day prediction promote random effect reduce reduced Region second study period vaccination Vaccine Worldwide [DOI] 10.3390/vaccines9111328 PMC 바로가기 [Article Type] Article
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccineArticle Published on 2021-11-112022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] Abstract accelerate accelerated accompanied acute respiratory syndrome addressed administration Alpha amplified antibody antibody level B cell B.1.1.7 BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine CD4 cellular circulating contribute coronavirus Coverage COVID-19 COVID-19 vaccine dose dosing interval effective expressing extended interval extension healthcare Humoral response IL-2 immunogenic immunogenicity individuals induce Infection introduced mRNA vaccine neutralization neutralizing antibody of BNT162b2 Protective protocol regimen response responses SARS-CoV-2 SARS-COV-2 infection second dose single dose sustained T cell the spike protein Trial United Kingdom Vaccine vaccine dose variant variants of concern [DOI] 10.1016/j.cell.2021.10.011 PMC 바로가기 [Article Type] Article
Application of artificial intelligence and machine learning for COVID-19 drug discovery and vaccine designCOVID-19 신약 개발 및 백신 설계를 위한 인공 지능 및 머신 러닝 적용Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antivirals application artificial intelligence caused combating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 pandemic drug Drug discovery effective drug effective drugs global pandemic machine learning offer optimization provide researcher SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Vaccine Vaccine design virus [DOI] 10.1093/bib/bbab320 PMC 바로가기 [Article Type] Article