Adaptive immune response – Page 14 – Communicable Diseases Research

PD-L1 Dysregulation in COVID-19 Patients

Immunology

Published on 2021-06-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Genetic risk for severe COVID‐19 correlates with lower inflammatory marker levels in a SARS‐CoV‐2‐negative cohort

Original Article

Published on 2021-06-062022-10-31
Journal: Clinical & Translational Immunology [Category] COVID-19,

[키워드] acute respiratory syndrome Adaptive immune response Affect age Alpha applied association baseline baseline level Blood Blood level body mass index Cohort coronavirus coronavirus disease COVID‐19 COVID‐19 patients COVID‐19 cytokine Effect electrochemiluminescence method endothelial explain genetic risk genetic risk score genotype data growth factor hypothesise IFN‐γ IFN‐γ increasingly individual Infection Inflammation Inflammatory Inflammatory marker inflammatory markers inflammatory protein Innate immunity interferon gamma marker Necrosis obesity objective overactive profile reduced Result risk SARS‐CoV‐2 SARS‐CoV‐2 serum Support susceptibility susceptible the cytokine storm TNF‐α TNF‐α variable Vascular
[DOI] 10.1002/cti2.1292 PMC 바로가기 [Article Type] Original Article

Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach

B 세포 고갈 약물로 성공적으로 치료된 환자의 장기간 및 중증 SARS-CoV-2 감염: 맞춤형 접근 방식

Case Reports

Published on 2021-06-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, 진단,

A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Review

Published on 2021-06-012022-10-30
Journal: Immunity & Ageing : I & A [Category] COVID-19,

[키워드] acute respiratory distress Adaptive immune response aggravate association cardiovascular disease cardiovascular diseases cascade cause characterized chronic inflammation Corona virus COVID-19 COVID-19 infection COVID-19 patients COVID-19 related mortality death deaths elderly Elderly patient elderly patients high mortality Host immune immunosenescence inflammatory process lung lymphocyte Microvascular thrombosis MODS Mortality multiple organ dysfunction New coronavirus pathophysiological mechanism Patient patients proportion subject syndrome systemic inflammatory response systemic inflammatory responses target triggering
[DOI] 10.1186/s12979-021-00234-z PMC 바로가기 [Article Type] Review

Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections

Review

Published on 2021-05-312022-10-28
Journal: Viruses [Category] COVID-19,

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Research Article

Published on 2021-05-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while
[DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article

Glycosylation is a key in SARS-CoV-2 infection

당화는 SARS-CoV-2 감염의 핵심입니다

Review

Published on 2021-05-222022-09-12
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, SARS, 진단,

[키워드] acting Adaptive immune response binding Blood group antigen cascade cause contribute COVID-19 cytokine disease epitope Epitopes Evidence Factor glycan glycans glycosylated glycosylation highlight host cell host cells IgG immune evasion Impact Infection innate and adaptive immune response monoclonal monoclonal antibody pandemic protective role Receptor-binding domain responsible S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein Serological testing shown spike glycoprotein Spike protein subsequent syndrome target cell target cells the receptor-binding domain the SARS-CoV-2 Therapeutic strategies therapeutic strategy therapy vaccination Vaccines virus
[DOI] 10.1007/s00109-021-02092-0 PMC 바로가기 [Article Type] Review

A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques

Article

Published on 2021-05-182022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] accumulates acute respiratory syndrome Adaptive immune response adjuvant Administered animal model Antibody Response BAL Bronchoalveolar lavage Cell challenge characteristic Chest clinical symptom collected controls coronavirus COVID-19 pandemic CTL CTL epitope downstream analysis Efficacy epitope expression Genome HLA class I immunogenic macaque macaques MHC class I MHC class I peptide microsphere nucleocapsid protein peptide peptide-based vaccine Peripheral blood persistent protection Protective public health recent rhesus macaques SARS-CoV-2 SARS-COV-2 infection sequence variation synthetic synthetic peptide T cell targeting TCID temperature tested the SARS-CoV-2 Transmission unique vaccination Vaccine Vaccines Viral load
[DOI] 10.3390/vaccines9050520 PMC 바로가기 [Article Type] Article

Intestinal Microbiota—A Promising Target for Antiviral Therapy?

장내 미생물군—항바이러스 치료의 유망한 표적인가?

Review

Published on 2021-05-122022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료제,

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

초기 인간 항-SARS-CoV-2 IgG의 높은 역가 및 낮은 푸코실화는 폐포 대식세포에 의한 염증을 촉진합니다

Research Article

Published on 2021-05-112022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response addition alveolar alveolar macrophage Alveolar macrophages anti-SARS-CoV-2 IgG Anti-spike anti-Spike IgG anti-spike protein IgG antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokines dependent on diagnosed disease driven by early phase Evidence excessive inflammatory response Fcγ receptor FcγR FDA feature fostamatinib glycosylation hallmark human macrophage IgG IIa in vitro induce infection with SARS-CoV-2 Inflammation Inflammatory response inhibitor initial interleukin interleukin-6 intrinsically Macrophage macrophage activation macrophages Microvascular thrombosis Necrosis occur Patient pro-inflammatory promote promote inflammation pulmonary endothelial receptor respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 second Seroconversion serum severe COVID-19 severe disease small molecule Spike protein syndrome therapeutic thrombosis Tumor tumor necrosis tumor necrosis factor was normalized worsening
[DOI] 10.1126/scitranslmed.abf8654 PMC 바로가기 [Article Type] Research Article