A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegansCaenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다Research Article Published on 2011-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn [DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article
Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a modelArticle Published on 2008-12-052022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] airway amplification amplify antibody approach approaches Cell culture cell line clinical samples coronavirus CPE, cytopathic effect Culture culture supernatant cultures Cytopathic effect described detect determine different time point epithelial evaluated experiment HAE HAE culture HAE, human airway epithelium HCoV-NL63 HCoV-NL63, human coronavirus NL63 Human identify Infection lack molecular NL63 nucleic acid pathogen Pathogens Propagation reagent reported respiratory pathogen respiratory viral respiratory virus SARS-CoV, severe acute respiratory syndrome coronavirus secretion sequence Sequence analysis TEM TEM, transmission electron microscopy Transcriptome transmission electron microscopy variety virus Whole transcriptome amplification WTA, whole transcriptome amplification [DOI] 10.1016/j.jviromet.2008.10.022 PMC 바로가기 [Article Type] Article
SARS Coronavirus DetectionDispatch Published on 2004-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] amplify assay coronavirus detect detection different Genome molecular diagnostics PCR Real-time PCR real-time RT-PCR Region SARS SARS-CoV sequence [DOI] 10.3201/eid1007.030678 PMC 바로가기 [Article Type] Dispatch