Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm
항-CD28 항체(TGN1412) 유발 사이토카인 폭풍 후 면역 재구성 및 임상 회복
Clinical Trial
[키워드] adverse event
adverse events
antibody
asymptomatic patients
autoantibody
Cancer immunotherapy
CD28
CD4
CD8
cells
clinical recovery
clinical trial
cognitive
Cognitive deficits
Concentration
consequence
COVID-19
cytokine
Cytokine dysregulation
cytokine release
Cytokine release syndrome
Cytokine storm
Cytokines
Day
declined
defined
dendritic cell
dendritic cells
Depression
described
diagnosed
dry gangrene
dysregulation
elevated
Follow-up
Gastrointestinal
healthy volunteer
IgE
immune
immune dysregulation
Immune monitoring
Immune-related adverse events (irAEs)
immunopathology
Immunotherapy
infections
initial
irAEs
irritability
memory
Mild-to-moderate
mucosal
naïve
neutropenia
observation
one patient
over
Patient
problem
problems
pruritus
Psychological
raynaud s phenomenon
required
serum cytokine
serum cytokines
subset
suffered
Symptom
systemic symptoms
T-cell
T-cells
T-regulatory cell
T-regulatory cells
targets
TGN1412.
Treatment
undetectable
[DOI] 10.1007/s00262-020-02725-2 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1007/s00262-020-02725-2 PMC 바로가기 [Article Type] Clinical Trial