binding domain – Page 14 – Communicable Diseases Research

One-Stop Serum Assay Identifies COVID-19 Disease Severity and Vaccination Responses

원스톱 혈청 분석으로 COVID-19 질병 심각도 및 백신 접종 반응 확인

Article

Published on 2021-05-172022-09-11
Journal: ImmunoHorizons [Category] SARS, 진단, 치료법,

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spike mutation T478K

Short Communication

Published on 2021-05-152022-10-04
Journal: Journal of medical virology [Category] SARS, 변종, 치료기술,

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

SARS-CoV-2 항체는 바이러스 뉴클레오캡시드 단백질 유도 보체 과활성화를 억제합니다

Article

Published on 2021-05-112022-09-10
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allosteric regulation Analysis antibodies antibody Antibody Response binding affinity binding domain changes in complement Complement cascade complex convalescent patient coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patients crystal structure dominant elicited epitope Epitopes foundation functional highest binding affinity Hyperactivation Infection mAb mAbs monoclonal antibodies monoclonal antibody morbidity morbidity and mortality N protein nucleocapsid Protein Regulation respiratory reveal risk factor RNA S protein SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 N protein SARS-CoV-2 S protein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus the N protein the SARS-CoV-2 while X-ray crystallography
[DOI] 10.1038/s41467-021-23036-9 PMC 바로가기 [Article Type] Article

Structural impact on SARS-CoV-2 spike protein by D614G substitution

Report

Published on 2021-04-302022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome added angiotensin-converting enzyme 2 appear bind binding domain biochemical circulating coronavirus COVID-19 pandemic D614G D614G substitution domain dominant epidemiologist Evolution facilitate forms full-length functional glycine Host host receptor increase Infection Interaction investigated less membrane fusion Microscopy modulate Mutation prefusion conformation Premature Prevent Protein S trimer SARS-CoV-2 SARS-CoV-2 spike protein Science spike spike trimer Spread structural rearrangement Structure Substitution the S1 subunit the SARS-CoV-2 the spike protein Vaccine development variant variants of concern viral entry viral spike viral spread
[DOI] 10.1126/science.abf2303 PMC 바로가기 [Article Type] Report

The antigenic anatomy of SARS-CoV-2 receptor binding domain

SARS-CoV-2 수용체 결합 도메인의 항원 해부학

Article

Published on 2021-04-152022-09-12
Journal: Cell [Category] MERS, SARS, 진단,

[키워드] Abstract ACE2 blockers Anatomy animal models antibody antibody binding site antigenic bind binding binding domain binding mode complex coronavirus, SARS-CoV-2, anti-RBD antibody, receptor binding domain, antibody, immune responses, virus structure data-driven dissect Emergency use epitope example Fab glycosylated human antibody response Human monoclonal antibody identify immune protection inhibitory inhibitory antibody Interaction mAb mAbs Map mapped Microscopy MOST N-terminal domain neutralize Neutralizing neutralizing antibody NTD panel of antibody prophylactically PROTECT Protein RBD RBD binding receptor Receptor binding domain recognizing Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor structures the RBD unique Virus spike X-ray crystallography
[DOI] 10.1016/j.cell.2021.02.032 PMC 바로가기 [Article Type] Article

Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection

새로운 ELISA 프로토콜은 기존 SARS-CoV-2 반응성 항체를 풍토성 코로나바이러스 면역 및 연령과 연결하고 다중 매개변수 감지를 통해 급성 COVID-19의 향상된 혈청학적 식별을 나타냅니다.

Immunology

Published on 2021-04-092022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Abbott Abbott test acute COVID-19 added age antibodies antibody Antibody detection antibody levels approved assays binding domain buffer circulating coated coronavirus COVID-19 COVID-19 pandemic detection Dilution disease disease status Economy ELISA ELISA protocol Endemic EUA HIV Hospitalized identification IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgM Immunity immunoassay impacted implication Improved infected individuals information life magnitude measurement Microparticle novel nuance nuances nucleocapsid (N) nucleocapsid protein optical densities optical density platform pre-existing immunity RBD reactive reagents receptor binding domain (RBD) reported SARS-CoV-2 SARS-CoV-2 IgM SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitive serologic serology serology test significantly lower SLE specific IgM standard curve Strains subject subjects Symptoms utility Viral protein Viral proteins virus transmission
[DOI] 10.3389/fimmu.2021.614676 PMC 바로가기 [Article Type] Immunology

Efficient Transient Expression of Recombinant Proteins Using DNA Viral Vectors in Freshwater Microalgal Species

Plant Science

Published on 2021-04-072022-10-31
Journal: Frontiers in Plant Science [Category] COVID-19,

[키워드] Chlamydomoans reinhardtii Chlorella vulgaris Agrobacterium Antigen approach binding domain Chlamydomona Chlorella develop DNA efficient effort Express expression FGF fibroblast geminiviral vector Genetic genetic transformation green algae growth factor Health increase in Infection microalgae microorganism nuclear nuclear transformation nutrient requirements organism overcome platform Protein Proteins provide quantification RBD recombinant Recombinant protein Replication repress Safe SARS-CoV-2 receptor Specy subcloned therapeutic therapeutic proteins Transient vector Viral vector were used western blot
[DOI] 10.3389/fpls.2021.650820 PMC 바로가기 [Article Type] Plant Science

Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor

ACE-2 수용체 억제에 의한 2019-nCoV에 대한 치료적 접근

Review

Published on 2021-04-012022-09-11
Journal: Drug research [Category] SARS, 치료제,

Neutralizing Monoclonal Anti-SARS-CoV-2 Antibodies Isolated from Immunized Rabbits Define Novel Vulnerable Spike-Protein Epitope

면역된 토끼에서 분리된 단일클론 항-SARS-CoV-2 항체 중화는 새로운 취약한 스파이크-단백질 에피토프를 정의합니다

Article

Published on 2021-03-262022-09-01
Journal: Viruses [Category] SARS, 변종, 진단,

[키워드] Anti-RBD antibodies antibody antibody repertoire Antigen approaches binding domain cell sorting characterization Combination Course COVID-19 COVID-19 therapy demonstrated Diagnosis diagnosis of SARS-CoV-2 disease distinct domain distinct domains domain Efficiency elicit epitope epitope mapping Epitopes Genetic variant immune response immunization immunized Immunotherapy IMPROVE in vitro Infection Isolated monoclonal antibodies monoclonal antibody mounted Neutralizing neutralizing antibody novel NTD Prevent profiles rabbit rabbit immunization RBD recombinant antigens repertoire representing SARS-CoV-2 SARS-COV-2 infection significantly Single Cell single cells single-cell sort specificity spike Spike protein the antibody the RBD therapy Viral viral spike protein
[DOI] 10.3390/v13040566 PMC 바로가기 [Article Type] Article

Bioinformatic Analysis of Genome-Predicted Bat Cathelicidins

Article

Published on 2021-03-232022-10-30
Journal: Molecules [Category] COVID-19,