Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective studyObservational Study Published on 2022-06-282022-10-04 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] Antibiotics Antigen Antiviral chest X-ray clinically combination therapy conducted cough COVID-19 COVID-19 pandemic discharged home Diseases Dyspnoea Epidemiology Final First wave greater handling hospital hospitalisation Hydroxychloroquine incidence Infection Infectious diseases laboratory characteristics Laboratory parameters Length mechanical ventilation Mortality Nasopharyngeal swab Negative PCR outcome pandemic Patient patients with COVID-19 peripheral oxygen saturation Pneumonia positive COVID-19 Real-time PCR required respiratory rate retrospective Retrospective study SARS-COV-2 infection second second wave secondary care significantly higher Steroids supplemental oxygen Symptom the patient were excluded [DOI] 10.1136/bmjopen-2022-061610 PMC 바로가기 [Article Type] Observational Study
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes Research Published on 2022-06-242022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] agonist Analysis baseline blood glucose China Chinese patient clinically Cohort cohorts conducted decreased appetite develop diarrhoea effective Efficacy effort eight enrolled evaluate Glucose Haemoglobin investigator involved MOST nausea nine obesity Open-label outcome Patient patients Placebo placebo-controlled plasma randomised randomised controlled trial receive receiving receptor reduced reductions in safety profile secondary subcutaneously T2D Tolerability Tolerance treat Treatment treatment-emergent adverse event type 2 diabete [DOI] 10.1038/s41467-022-31328-x [Article Type] Research
Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With Myasthenia Gravis중증 근무력증 환자에서 SARS-CoV-2 mRNA-1273 백신의 면역 반응 및 안전성Observational Study Published on 2022-06-212022-09-12 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI activity adverse event AEs baseline blood sample cellular Cellular immune response cellular response changes in class classification clinical clinically collected Combined therapy conducted coronavirus disease correlated country Course COVID-19 determine doses Efficacy ELISA Evidence first dose humoral immune response immunosuppressive drug immunosuppressive therapy induce interferon gamma Messenger RNA mRNA mRNA vaccination mRNA-1273 mRNA-1273 vaccine Myasthenia occurred Participants Patient performed plasma Prednisone Primary outcome Prospective Study provide receiving response Safe Safety SARS-CoV-2 second dose Seroconversion significant changes in statistically significant Surveillance Symptom T-cell T-cell Response the disease the patient vaccination vaccination schedule Vaccine were assessed were measured worsening [DOI] 10.1212/NXI.0000000000200002 PMC 바로가기 [Article Type] Observational Study
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 PatientsObservational Study Published on 2022-06-212022-10-04 Journal: Antimicrobial Agents and Chemotherapy [Category] 임상, [키워드] 50% effective concentration accumulates clearance clinically collected Concentration coronavirus disease covariate COVID-19 COVID-19 patient COVID-19 patients daily dose dependent on described distribution dose dosing regimen Effectiveness elimination half-life evaluated explain glomerular filtration rate GS-441524 Hospitalized hospitalized COVID-19 patient Hypoxemia identify IMPROVE in vitro metabolite mixed-effects model Patient patients pharmacokinetic pharmacokinetics plasma plasma concentration Population Probability reduced Remdesivir renal function therapy Treatment Variability Volume was performed [DOI] 10.1128/aac.00254-22 PMC 바로가기 [Article Type] Observational Study
Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19성숙한 호중구와 NF-κB에서 IFN으로의 전환은 COVID-19에서 통합된 질병 회복 역학을 결정합니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] 바이오마커, 유전자 메커니즘, [키워드] Blood Cell cell deconvolution cellular cellular and molecular Cellular and molecular mechanisms changes changes in clinically courses COVID-19 decrease determine differentiation disease disease modeling disease recovery Effect framework Gene regulation heterogeneous homeostasis immune immunology implication indication interferon Kinetics mechanisms Medicine neutrophil NF-κB other disease other diseases outcome Patient presenting Regulatory restoration resulting severe COVID-19 Systems biology T cell T cell activation the disease tissues transcriptomes viral infection [DOI] 10.1016/j.xcrm.2022.100652 PMC 바로가기 [Article Type] Article
Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications단핵구 anisocytosis는 심혈관 합병증이있는 어린이의 다기관 염증 증후군 동안 증가합니다Article Published on 2022-06-202022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Accuracy Analysis anisocytosis blood count blood sample Blood samples Cardiac complications cardiovascular complication Care CBC Child children children with MIS-C clinically Cohort collected complete blood count complex COVID-19 creating develop diagnostic Diagnostic accuracy disease distribution effective enrolled greater healthy controls hematologic identify illnesses IMPROVE increase Inflammatory initial Laboratory Laboratory test life-threatening Medical care MIS-C monocyte Monocyte distribution width multisystem inflammatory syndrome in children New on children outcome parameters pediatric COVID-19 quantified required risk SARS-COV-2 infection sensitivity single medical center specificity subject syndrome tested threshold time-consuming Treatment utility validation cohort [DOI] 10.1186/s12879-022-07526-9 PMC 바로가기 [Article Type] Article
Patient and health practitioner views and experiences of a cancer trial before and during COVID-19: qualitative studyCOVID-19 이전과 동안의 암 시험에 대한 환자 및 의료 종사자의 견해와 경험: 정성적 연구Article Published on 2022-06-182022-09-11 Journal: Trials [Category] 임상, [키워드] approach Arm benefit Cancer changed clinical clinical trial clinical trials clinically communication Contact contact with COVID-19 described ENhance Equipoise Evidence First wave Haematological cancer Haematology Health Health practitioner increased risk increased the risk information less life Life change events lymphoma NHS outcome pandemic pathway Patient Perspective PETReA Practitioner practitioners preference Qualitative randomisation Randomised controlled trials risk Support Treatment Trial Uncertainty understanding while [DOI] 10.1186/s13063-022-06453-z PMC 바로가기 [Article Type] Article
Redefining critical illness Reviews Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, [키워드] accelerate acute respiratory syndrome approach Basic science change clinical trial clinically coronavirus Critical Critical care defined determinant effective heterogeneous Mounting outcomes Patient recent finding Research Respiratory failure respond SARS-CoV-2 Support therapy translational Treatment turn [DOI] 10.1038/s41591-022-01843-x [Article Type] Reviews
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial