Circulating multimeric immune complexes contribute to immunopathology in COVID-19Article Published on 2022-09-262022-11-15 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료제, [키워드] activating Activation Antiviral circulating comparable contribute COVID-19 COVID-19 progression Critical detrimental disease driven by dysregulated immune response Evidence extreme FcγRs humoral identify IgG IgG response immune complex immunopathology independent Intervention Ligand mitigate paradoxical Patient patients Protective reporter robust SARS-CoV-2 severe COVID-19 SLE specific IgG antibody systemic immune dysregulation systemic lupus erythematosus triggering with mild disease [DOI] 10.1038/s41467-022-32867-z PMC 바로가기
Pre-analytical sample stabilization by different sampling devices for PCR-based COVID-19 diagnosticsPCR 기반 COVID-19 진단을 위한 다양한 샘플링 장치에 의한 사전 분석 샘플 안정화Article Published on 2022-09-252022-09-11 Journal: New biotechnology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Bacterial cell culture systems copy number copy numbers COVID-19 Critical detectability detectable diagnostic diagnostic testing diagnostics examined except for gold gold standard growth handling healthcare worker infectious Infectivity inhibited outbreak pandemic Patient Pre-analytic Quantitative RT-PCR reduction remained RNA RNA stability room temperature Saliva Saliva collection devices SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA Sensitivity and specificity specimen specimen collection stability Swab Swab systems. temperature test results tested the SARS-CoV-2 Transport Viral Viral RNA [DOI] 10.1016/j.nbt.2022.04.001 PMC 바로가기 [Article Type] Article
Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and DistrictsArticle Published on 2022-09-242022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] affected age analyses applied B.1.1.7 Care coronavirus disease Coronavirus disease 2019 (COVID-19) covariate COVID-19 COVID-19 patient Critical develop discrepancy distribution District Effect epidemiological fatality Germany Government Health health care systems hospital ICU ICU patient Infection Inpatients Intensive intensive care intensive care unit Intervention limit Local management mathematical mathematical model mechanical ventilation modeling National Non-pharmaceutical interventions outcome pandemic patient age performed positive recorded reduce regions reported resources SARS-CoV-2 SARS-COV-2 infection severity Sex Spread state Testing strategy Variability variant variant of concern (VOC) VoC [DOI] 10.3390/v14102114 PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Burden of Pediatric SARS-CoV-2 Hospitalizations during the Omicron Wave in GermanyArticle Published on 2022-09-222022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] Admission age burden children connection COVID-19 Critical disease severity Germany Healthcare system hospital Hospital admissions Hospitalization Hospitalized hospitalized patients hospitals incidence rate Infectious disease intensive care treatment intensive care units median National omicron Patient pediatric per day remained Respiratory Support SARS-CoV-2 Society symptomatic SARS-CoV-2 infection Transmissibility treated variant variant of SARS-CoV-2 Wave were recorded [DOI] 10.3390/v14102102 PMC 바로가기
COVID-19 Vaccines against Omicron Variant: Real-World Data on EffectivenessArticle Published on 2022-09-202022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] booster dose circulation clinical study clinical trial clinical trials coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines Critical database Effectiveness Efficacy emergence forms Immunity maintain omicron Population real-world data reference SARS-CoV-2 subpopulations Vaccine Vaccines variants of concern VoC [DOI] 10.3390/v14102086 PMC 바로가기
Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2Article Published on 2022-09-202022-10-06 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody BA.1 BA.2 Body weight loss circulating coronavirus COVID-19 Critical dependent on dominant feature in vitro in vivo models indicate investigated K18-hACE2 mice less lung Lungs nasal turbinate nasal turbinates omicron pathogenicity protease public health recent replicate Replication SARS-CoV-2 SARS-CoV-2 variant serine 2 survival TMPRSS2 transmembrane Virological virus entry [DOI] 10.1016/j.xcrm.2022.100743 PMC 바로가기 [Article Type] Article
A computational study of metal-organic frameworks (MOFs) as potential nanostructures to combat SARS-CoV-2Article Published on 2022-09-202022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 antibody antiviral drug binding biological molecule carrier coronavirus COVID-19 Critical deformation determine drug host cells inhibitor Interaction investigated M pro MOF molecular nanobody non-structural protein protease Protein receptor S protein SARS-CoV-2 secondary structure Spike protein surface protein tested Vaccine virus replication [DOI] 10.1038/s41598-022-19845-7 PMC 바로가기
Human genetic basis of severe or critical illness in COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome affecting association Asymptomatic base caused contribute coronavirus COVID-19 Critical Critical illness death determinant disease disease severity enhanced Enzymes Factor Genetic Genetic variation genetic. Host Human human leukocyte antigen immune component indicated Interaction Interleukins loci mild infection morbidity and mortality multi-organ dysfunction outcome Precision preventive measure Respiratory failure SARS-CoV-2 SARS-CoV-2 receptor Serine severity of COVID-19 Toll-like receptor transmembrane [DOI] 10.3389/fcimb.2022.963239 PMC 바로가기
The impact of CoronaVac on the neutralization breadth and magnitude of the antibody response to SARS-CoV-2 virusesArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] 95% confidence interval addition Anti-RBD IgG B.1.1.529 B.1.351 B.1.617.2 Beta booster booster dose booster vaccination Booster vaccine breadth Cohort convalescent COVID-19 patient CoronaVac Critical cross-neutralization Delta dose examined highlight homologous immune response increase in less log magnitude neutralization neutralization breadth neutralization titer neutralize omicron positive proportion receiving recipient reduction reported Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Significant the antibody response vaccination Vaccine variant variants wild-type [DOI] 10.3389/fimmu.2022.990071 PMC 바로가기