cytokine production – Page 14 – Communicable Diseases Research

Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune system

Research

Published on 2019-08-052022-10-28
Journal: Virology Journal [Category] Coronavirus, MERS,

[키워드] Activation amino acid residue analyzed canonical cause cells compose coronavirus Critical cytokine production Degradation demonstrated develop diarrhea domain dose-dependent inhibition downregulation enzyme activity evade exhibited family Coronaviridae gastroenteritis Host host immune system host innate immunity identify immunoprecipitation individual Infection inflammatory factors inhibit inhibiting inhibitory effect innate immune innate immune response involved IκBα modulating modulation mRNA expression NF-κB NF-κB NF-κB signaling non-structural protein nonstructural protein 3 Nsp3 nuclear nuclear translocation p65 Pathogenesis pathway Phosphorylation PLP PLP2 previous study Protein provide quantitative PCR reporter Result signaling pathway TGEV transmissible gastroenteritis virus ubiquitination Viral protein virus was used watery
[DOI] 10.1186/s12985-019-1206-9 PMC 바로가기 [Article Type] Research

Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs

CAF09 보조제를 사용한 저항원 용량이 괴팅겐 미니피그의 복강 내 면역화 후 세포독성 T세포 반응을 유도한다.

Article

Published on 2017-10-092024-08-19
Journal: Vaccine [Category] 파상풍,

[키워드] Administration route Antibody responses Antigen dose cytokine production Cytotoxic T cells immunization
[DOI] 10.1016/j.vaccine.2017.08.057

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

T 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다

Research Article

Published on 2016-07-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1
[DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article

Low antigen-specific CD4 T-cell immune responses despite normal absolute CD4 counts after long-term antiretroviral therapy an African cohort

장기 항레트로바이러스 치료 후 아프리카 집단에서 정상적인 절대 CD4 수치에도 불구하고 낮은 항원 특이적 CD4 T세포 면역 반응

Article

Published on 2015-08-072024-08-23
Journal: Immunology letters [Category] 폐렴구균 감염증,

[키워드] ART CD4 T-cell proliferation cytokine production immune recovery sub-Saharan Africa Uganda
[DOI] 10.1016/j.imlet.2014.09.016 PMC 바로가기 [Article Type] Article

Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen

Research Article

Published on 2014-11-182022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] adjuvant antibody Antigen BALB/c mice Cell-mediated immunity cellular immune responses cellular immunity Combination CpG Critical cytokine production delivery effective elicited ELISpot assay evaluated Freund’s adjuvant humoral Humoral immunity hydroxide hypothesised IFA IFN-γ IgG immune response Immunity immunized immunogenic IMPROVE indicated intramuscularly investigated MERS-CoV MERS-CoV RBD mice Middle East Modification murine Neutralizing antibodies neutralizing antibody offered pandemic Protein purified RBD regimen respiratory respiratory syndrome coronavirus robust route rRBD spot-forming cell subunit T-cell Response the receptor-binding domain vaccination Vaccine was tested
[DOI] 10.1371/journal.pone.0112602 PMC 바로가기 [Article Type] Research Article

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

Research

Published on 2014-08-202022-10-30
Journal: Journal of Neuroinflammation [Category] Coronavirus,

[키워드] Affect Anti-viral immune response approved CD4+ CD8+ T cell Central nervous system clinical disease CNS correlated cytokine production cytolytic Demyelination disease disease severity disease-causing dose drug Effect effective examined exhibited expression flow cytometry food FTY720 IFN-γ infiltration Inflammatory inhibiting Lymph node lymphocyte mice Migration modulate morbidity and mortality Mortality mouse hepatitis virus multiple sclerosis Neuroinflammation neurologic neurotropic not affect occur Patient Post-infection proliferation recorded reduce reduction in Result S1P receptor severity staining T lymphocyte T lymphocytes Therapeutic benefit TNF-α treated Treatment viral replication viral-induced virus virus-specific T cell was determined were infected
[DOI] 10.1186/s12974-014-0138-y PMC 바로가기 [Article Type] Research

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection

Research Article

Published on 2004-09-092022-10-28
Journal: BMC Infectious Diseases [Category] Coronavirus,

[키워드] 24 hours activated acute respiratory syndrome Analysis Antibody binding array assay Blood cell activation change chemokine clinical feature Coagulation coronavirus CoV cytokine production described disease pathology distress donors examined Gene Expression healthy donor high-density host response IL17 IL8 immune response in vitro indicated infecting Infection infiltration inhibited inoculated interstitial interstitial inflammation lung trafficking lymphopenia mechanism molecular basis monocyte-macrophage mononuclear cell Pathogenesis pathology pathway PBMC PBMCs Peripheral blood provide Quantitative assays Result SARS Coronavirus SARS patient SARS-CoV Signaling specific antibody the disease TLR9 upregulation viral replication viral replication kinetics
[DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article