Zinc aspartate induces proliferation of resting and antigen-stimulated human PBMC under high-density cell culture conditionArticle Published on 2023-05-012023-06-24 Journal: Journal of trace elements in medicine and biology [Category] 신종인플루엔자, [키워드] Apoptosis cytokine production PBMC proliferation Zinc aspartate. [DOI] 10.1016/j.jtemb.2023.127152
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic healthArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 진단, [키워드] affected cardiometabolic cardiovascular Cluster Complication country COVID COVID-19 COVID-19 pandemic COVID-19 severity CVD cytokine cytokine production diabetes Final hallmark Health hypertension IL-6 IL10 IL2 IL4 IL8 immune system increased the risk infected patient Inflammation inflammatory state influence molecular morbidity and mortality obese pathophysiological Patient predictor pro-inflammatory reported resulting SARS-CoV2 systemic damage target type 2 diabete virus [DOI] 10.1016/j.bbadis.2022.166559 PMC 바로가기
Humoral and cellular immune responses to CoronaVac up to one year after vaccinationArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] all subject Antibody Response Antiviral CD4^{+} T cell cellular Cellular immune response cellular response clinical trial CoronaVac cytokine production cytokine profile defined effector memory evaluated follicular humoral Humoral response immune immune memory immune response impacted Inactivated vaccine individual induce memory Older peaked Phase 3 response SARS-CoV-2 SARS-CoV-2-specific IgG SARS-CoV-2-specific immune responses second dose sustained T cell activation T cell phenotype Tfh Th2 vaccination vaccine dose vaccinees [DOI] 10.3389/fimmu.2022.1032411 PMC 바로가기
The interplay between the airway epithelium and tissue macrophages during the SARS-CoV-2 infectionArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] 3D cultures activate added Air-liquid interface air-liquid interface (ALI) airway airway epithelium Antigen presentation antiviral immune response basolateral side cell type co-culture Contact Course Culture cytokine production cytokine release demonstrated driven by epithelial epithelial cells evaluate HAE hMDM hMDMs Human airway epithelium human airway epithelium (HAE) human monocyte-derived macrophage immune response in viral infected cell Infection Innate immunity lung Macrophage macrophages phagocyte primary human airway recruitment Replication SARS-CoV-2 SARS-COV-2 infection Spread the SARS-CoV-2 tissue macrophage transfer virus virus replication [DOI] 10.3389/fimmu.2022.991991 PMC 바로가기
COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctionsArticle Published on 2022-10-012022-11-15 Journal: European Journal of Immunology [Category] 바이오마커, [키워드] accompanied Biomarker blood leukocyte Cell cells COVID-19 COVID-19 patients cytokine production Cytokines dendritic cell dendritic cells dysfunction hyporesponsiveness increase induce innate immune innate immune cell Intervention LPS Monocytes myeloid-derived suppressor cells sustained target upregulation [DOI] 10.1002/eji.202249827 PMC 바로가기
Identification of serum metabolites enhancing inflammatory responses in COVID-19Article Published on 2022-10-012022-11-15 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype [DOI] 10.1007/s11427-021-2099-7 PMC 바로가기
Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosisArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant [DOI] 10.3389/fimmu.2022.945583 PMC 바로가기
Neuroinflammation in Dementia-Therapeutic Directions in a COVID-19 Pandemic SettingArticle Published on 2022-09-222022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] activate Activation Affect cognitive complications Concentration COVID-19 cytokine production Dementia direction dysfunction Efficacy Factors Glia glial cell glial cells group of diseases heterogenous highlight human organism IL-1β immune response Inconclusive Inflammation Inflammatory Intervention molecular neurodegenerative Neuroinflammation Neuron NSAID outcome pathology peripheral pro-inflammatory signaling provide resulting risk SARS-CoV-2 setting shown Side effects therapeutic approaches TNF TNF antagonist TNF antagonists while [DOI] 10.3390/cells11192959 PMC 바로가기
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Identifying potential pharmacological targets and mechanisms of vitamin D for hepatocellular carcinoma and COVID-19Article Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 진단, 치료제, [키워드] ACTA1 aggressiveness ALB analyses Analysis analyzed Anti-inflammatory anti-inflammatory action Antiviral effect binding activity bioinformatics Biological functions chemokine Coronavirus disease 2019 COVID-19 cytokine production digestive system Effect effective enrichment analysis epithelial evaluate HCC HCC patient HCC patients help hepatocellular Hepatocellular carcinoma HMOX1 identifying immune response immunomodulatory involved malignancy mechanism molecular molecular docking molecular mechanism network pharmacology pandemic performed pharmacological target poor prognosis Predictive Prognosis prognostic public health RBP4 Regulation risk Seven signaling pathway target gene Target genes therapeutic effect TLR4 TTR Vitamin D with COVID-19 [DOI] 10.3389/fimmu.2022.985781 PMC 바로가기