Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in IsraelSpecial Issue on the COVID-19 Pandemic Published on 2020-07-312022-10-28 Journal: Rambam Maimonides Medical Journal [Category] COVID-19, [키워드] benefit Care challenge Characteristics clinical evidence clinical implications Community complex coronavirus disease COVID-19 COVID-19 pandemic Critical care Deleterious described develop development developmental disease effective Efficiency effort equipment Evidence Government Health Health care system health care technology hospital implication In-hospital individual infective information information management Isolation knowledge lack management Measures mitigate National organization pandemic pathophysiology Patient Patient care reducing required Research risk setting shown Spread strategic patient management the disease threat treatment guidelines vital signs while [DOI] 10.5041/RMMJ.10417 PMC 바로가기 [Article Type] Special Issue on the COVID-19 Pandemic
Mutation analysis, treatment and prenatal diagnosis of Chinese cases of methylmalonic acidemiaArticle Published on 2020-07-272022-10-04 Journal: Scientific Reports [Category] 변종, 유전자 메커니즘, [키워드] Analysis caused Chinese clinically counseling developmental Diagnosis disease Diseases expand Genetic Genotype healthy hematological Identified identify liquid MCEE Medical research MMACHC MMUT Molecular medicine Mutation neurological Newborn Next-generation sequencing Patient Pregnancy prenatal Prognosis provided required Sanger sequencing Seven treatable Treatment variant was performed [DOI] 10.1038/s41598-020-69565-z PMC 바로가기 [Article Type] Article
Respiratory conditions in coronavirus disease 2019 (COVID-19): Important considerations regarding novel treatment strategies to reduce mortalityResearch article Published on 2020-07-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 치료법, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV/SARS-CoV-2 acute respiratory distress ARDS binding Blood cause Cell Chloroquine clinically condition conditions coronavirus disease COVID-19 COVID-19 cases COVID-19 patient Critical described develop developmental effective EPO feature hallmark hemoglobin high mortality Hydroxychloroquine imperative life-threatening management medication Organ failure oxygen Oxygen therapy Oxygenation pulmonary reduce mortality respiratory respiratory symptoms SARS-CoV-2 Sickness significantly Stage Support Symptom syndrome therapeutic therapeutic intervention therapy tissue Treatment treatment strategy treatments for COVID-19 Trial Vaccine ventilator virus with COVID-19 [DOI] 10.1016/j.mehy.2020.109760 [Article Type] Research article
From causes of aging to death from COVID-19Review Published on 2020-06-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] age aging cause cellular coronavirus COVID-19 Cytokine storms death developmental diabete disease Diseases driven by explain faster growth hyperinflammation hypertension increase manifestation men Mortality mTOR Patient rapalogs Rapamycin SARS-CoV-2 senolytics syndrome with COVID-19 women [DOI] 10.18632/aging.103493 PMC 바로가기 [Article Type] Review
Repurposing chlorpromazine to treat COVID-19: The reCoVery studyResearch article Published on 2020-06-012022-10-05 Journal: L'Encéphale [Category] SARS, 신약개발, [키워드] alleviate Anti-SARS-CoV-2 Activity antiviral activity antiviral properties biodistribution blind Brain caused chlorpromazine Clathrin-mediated endocytosis clinical trial contagiousness Course COVID-19 COVID-19 infection COVID-19 pandemic CPZ developmental exhibit form France ICU care incidence individuals Infection lung multicenter neuroscience objective observation offer Paris Patient Prophylactic PROTECT psychotropic drug Randomized Recentin reduce reported repurposing Repurposing of molecules Respiratory Support Saliva SARS-CoV-2 severity Side effects standard treatment symptomatic therapeutic therapy Tolerance treat Trial virulent [DOI] 10.1016/j.encep.2020.05.006 [Article Type] Research article
The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?Review Published on 2020-05-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accompanied adipose tissue dysfunction adverse outcomes affected circulating cytokines complex COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients Critical cytokine Cytokine storm Deleterious develop developmental diabete diabetes diabetics Evidence explain GEMM family study hyperglycemia hyperinflammatory state hyperinsulinemia immune response Infection Infectious disease Inflammation insulin resistance manifestation mechanism meet morbidity multi-organ failure multifactorial Non-communicable disease pandemic pathogen pathology pathway Patient patients with diabete patients with diabetes prevalent proinflammatory prothrombotic recent risk factor severe COVID-19 subject suggested survival susceptibility symptoms of COVID-19 syndrome time triggering underlie [DOI] 10.3390/pathogens9050389 PMC 바로가기 [Article Type] Review
Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure구강으로 인한 임신 및 신생아 아트라진 노출의 장기 면역독성 효과Article Published on 2019-04-012024-08-24 Journal: Toxicological Sciences [Category] 폐렴구균 감염증, [키워드] atrazine developmental Immunity
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicansp38/HOG 스트레스 활성화 단백질 키나제 네트워크는 칸디다 알비칸스의 성장과 분열을 연결합니다Research Article Published on 2019-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis basal Candida Candida albican Candida albicans Cell cell cycle cell division cell growth cell proliferation commitment complex conserved Control Critical developmental division environmental cues eukaryotic eukaryotic cell eukaryotic cells G1 Phase G1/S transition Gene Expression Genetic growth homeostasis identify inhibit inhibited kinases knowledge MAPK mutant mutants nexus overlapped pathogenic yeast performed plasticity Point problem promoter promoters Protein protein kinase protein kinases Quantitative Regulation regulatory pathway respond restriction ribosome biogenesis Saccharomyces cerevisiae threshold Transcription transcription factor transcription factors transcriptional regulator transcriptional regulators yeast [DOI] 10.1371/journal.pgen.1008052 PMC 바로가기 [Article Type] Research Article
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target spaceHsf1 수준을 조정하면 고갈이 Hsp90 기능을 손상시키고 과발현이 대상 공간을 확장하여 독특한 곰팡이 형태 발생 프로그램을 구동합니다.Research Article Published on 2018-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence bypassing Candida albican Candida albicans cellular changes in chaperone complex conserved Control Critical defend Depletion developmental dose-dependent driving elevated temperature environmental cue environmental cues Fever fluctuation form functional fungal fungal pathogen Gene Expression growth Heat shock highlight Host host response hosts Hsf1 Hsp90 Human impairing induce Infection mammalian mechanism microorganism microorganisms modulate molecular morphogenesis observé overexpression pathogen Pathogens physiological temperature positive provide regulate Regulation required respond survival target temperature transcription factor transcriptional tuning virulence yeast [DOI] 10.1371/journal.pgen.1007270 PMC 바로가기 [Article Type] Research Article
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignanciesSchinzel-Giedion 증후군 및 혈액 악성 종양에서 중복 SETBP1 기능 획득 돌연변이Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation activating affecting alteration alterations Author Cancer caused cell proliferation cellular characterized clinical information clinical phenotype Clustering Cohort collected de novo de novo mutation Degradation developmental developmental disorder developmental disorders disrupt Disruption distribution Drawing driven by driving Effect event events ExoN functional gain-of-function genetics Genotype genotype-phenotype correlation germline Hematologic malignancy hotspot implicated in silico in vitro incidence increase in increased risk individual lead leukemia magnitude malformation malignancy Mendelian disorder Mendelian disorders molecular Mutation mutations neurological occur overlap Patient phenotype prenatal development Previous studies previous study Protein protein level protein levels Regulation required residue risk SETBP1 signal significantly more somatic mutation somatic mutations stability subject Substitution substitutions Support syndrome threshold [DOI] 10.1371/journal.pgen.1006683 PMC 바로가기 [Article Type] Research Article