A Cell-Free Assay for Rapid Screening of Inhibitors of hACE2-Receptor-SARS-CoV-2-Spike BindingArticle Published on 2022-04-152023-07-08 Journal: ACS synthetic biology [Category] COVID19(2023년), [키워드] Drug repurposing functionalized nanoparticle inhibitor protein−protein interaction. RNA-protein granule [DOI] 10.1021/acssynbio.1c00381 PMC 바로가기
Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking studyArticle Published on 2022-04-072022-11-15 Journal: F1000Research [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] antiviral drug Antiviral effect arising B.1.1.7 B.1.351 B.1.351 variant B.1.617.2 Baricitinib binding binding affinity change conducted COVID-19 determine Dexamethasone drug Drug repurposing experiments Favipiravir Genetic variant investigated mitigate molecular docking molecular dynamics Mutation outbreak Previous studies public health Receptor binding domain Remdesivir residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant several variant Surface glycoprotein the SARS-CoV-2 virus Transmission treat virulence VOCs Wuhan, China [DOI] 10.12688/f1000research.109586.1 PMC 바로가기
Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studiesResearch article Published on 2022-04-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] active against anti-SARS-CoV-2 approach binding mode Compound computational method COVID-19 database docking Drug repurposing effective Efficacy Enzymes in silico inhibitor inhibitory effect initial management MD simulation molecular docking molecular dynamics Molecular dynamics simulation MPro notable phytochemicals Phytomedicine PLPro polymerase protease RdRP repurposing SARS-CoV-2 SARS-COV-2 infection screened selected steroid therapeutic target Toxicity [DOI] 10.1016/j.sjbs.2021.12.018 [Article Type] Research article
Identification and characterization of novel RdRp and Nsp15 inhibitors for SARS-COV2 using computational approach컴퓨터 접근 방식을 사용한 SARS-COV2에 대한 새로운 RdRp 및 Nsp15 억제제의 식별 및 특성화Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alectinib approach caused Compound coronavirus COVID-19 COVID19 different disease different diseases drug Drug repurposing effective inhibitor EndoU enzyme Ergotamine health emergency Health Organization highlight homology homology modeling hydrogen Hydrogen bond hydrophobic identification inhibitor inhibitors Interaction MD simulation molecular molecular interaction molecular mimicry Naldemedine Nsp15 observé pathogen performed Protein target RdRP residue RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Therapeutics Virtual screening were used World Health Organization [DOI] 10.1080/07391102.2020.1841026 PMC 바로가기 [Article Type] Article
Drug repurposing strategies and key challenges for COVID-19 managementReview Published on 2022-04-012023-07-07 Journal: Journal of drug targeting [Category] COVID19(2023년), [키워드] clinical trials Drug repurposing drug targets pathophysiology SARS-CoV2 [DOI] 10.1080/1061186X.2021.2013852 [Article Type] Review
Computational repurposing of asthma drugs as potential inhibitors of SARS-CoV-2 MproCorrespondence Published on 2022-04-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, [키워드] Asthma Asthma drugs COVID-19 drug Drug repurposing inhibitors of SARS-CoV-2 molecular docking MPro SARS-CoV-2 [DOI] 10.1016/j.nmni.2022.100979 [Article Type] Correspondence
SARS-CoV-2 M pro inhibitors: identification of anti-SARS-CoV-2 M pro compounds from FDA approved drugsArticle Published on 2022-04-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis anti-SARS-CoV-2 binding affinity binding free energy caused complex Compound Coronavirus replication Correlation analysis COVID-19 COVID-19 pandemic cysteine protease database docking drug Drug discovery Drug repurposing end point enzyme FDA approved drug in vitro in vivo Interaction Ligand M pro molecular molecular docking Molecular dynamics simulation Molecular simulation N3 inhibitor outbreak public health R428 raised recent SARS-CoV-2 screened stability Structure-based virtual screening Teniposide viral life cycle Virtual screening VS-5584 [DOI] 10.1080/07391102.2020.1842807 PMC 바로가기 [Article Type] Article
Mechanisms of action of fluvoxamine for COVID-19: a historical reviewReview Published on 2022-04-012022-10-04 Journal: Molecular Psychiatry [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] accelerate acute respiratory syndrome caused Clinical data coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic death disorder Drug repurposing Increasing intubation mechanism Mild moderate Neuropsychiatric offspring pandemic Prophylactic receptor reduced risk risk SARS-CoV-2 Schizophrenia Serotonin subject therapeutic drug virus with COVID-19 [DOI] 10.1038/s41380-021-01432-3 PMC 바로가기 [Article Type] Review
Effect of chronic hydroxychloroquine use on COVID-19 risk in patients with rheumatoid arthritis and systemic lupus erythematosus: a multicenter retrospective cohortMulticenter Study Published on 2022-04-012022-10-04 Journal: The Journal of international medical research [Category] 신약개발, [키워드] acute respiratory syndrome anti-viral activity ARMS association breathing difficulty chronic drug chronic drug use clinics Complication complications of COVID-19 coronavirus disease Coronavirus disease 2019 COVID-19 disease disease complication Drug repurposing dry cough Effect examined fatigue Fever HCQ Health hospital Hydroxychloroquine incidence incidence of COVID-19 multicenter pandemic Patient patients positive reported retrospective cohort retrospective cohort study rheumatoid arthritis rheumatology risk Saudi Arabia severe acute respiratory syndrome coronavirus-2 study cohort systemic lupus erythematosus two group [DOI] 10.1177/03000605221090363 PMC 바로가기 [Article Type] Multicenter Study
Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19Review Published on 2022-03-302023-07-02 Journal: International Journal of Molecular Sciences [Category] SARS, [키워드] acid sphingomyelinase Clinical studies COVID-19 Drug repurposing FIASMA Fluoxetine fluvoxamine lysosomotropic agents SARS-CoV-2 sigma-1 receptors SLC22A3 SSRI [DOI] 10.3390/ijms23073812 PMC 바로가기 [Article Type] Review