ROS1 kinase inhibition reimagined: identifying repurposed drug via virtual screening and molecular dynamics simulations for cancer therapeuticsChemistry Original Research Published on 2024-07-292024-09-05 Journal: Frontiers in Chemistry [Category] update2024, [키워드] Alectinib Drug repurposing Essential dynamics Midostaurin molecular dynamics simulations ROS proto-oncogene 1 Virtual screening [DOI] 10.3389/fchem.2024.1392650 PMC 바로가기 [Article Type] Chemistry Original Research
Drug repurposing of pyrazolotriazine derivatives as potential anti-SARS-CoV-2 agents: in vitro and in silico studiesResearch Published on 2024-07-162024-09-05 Journal: BMC Chemistry [Category] update2024, [키워드] COVID 19 Drug repurposing main protease Mpro molecular docking Pyrazolotriazine SARS-CoV-2 [DOI] 10.1186/s13065-024-01233-z PMC 바로가기 [Article Type] Research
A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complicationsArticle Published on 2024-06-122024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] (E)‐5‐methoxy‐1‐[4‐(trifluoromethyl)phenyl]pentan‐1‐one O‐2‐aminoethyl oxime) antidepressant coronavirus Disease prevention Drug repurposing Drug safety Infectious diseases Neurochemistry Neurological disorders pandemic Pharmacology Psychiatric disorders public health Respiratory tract diseases SARS-CoV-2 Sigma-1 receptor (σ1R) Target identification Therapeutics viral infection [DOI] 10.1038/s41598-024-64260-9 PMC 바로가기 [Article Type] Article
The Role of the Immune System in Pathobiology and Therapy of Myocarditis: A ReviewReview Published on 2024-05-232024-09-05 Journal: Biomedicines [Category] update2024, [키워드] Autoimmune disease Drug repurposing immune system immunosuppressive therapy myocarditis systemic immune-mediated disease [DOI] 10.3390/biomedicines12061156 PMC 바로가기 [Article Type] Review
Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomasCase Study Published on 2024-05-022024-09-05 Journal: Briefings in Bioinformatics [Category] update2024, [키워드] Cancer Drug repurposing glioma Metabolic modeling [DOI] 10.1093/bib/bbae199 PMC 바로가기 [Article Type] Case Study
Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 InfectionsArticle Published on 2024-04-222024-09-05 Journal: Viruses [Category] update2024, [키워드] Antiviral agents coronavirus COVID-19 Drug repurposing pharmacokinetics potency potential efficacy SARS-CoV-2 [DOI] 10.3390/v16040651 PMC 바로가기 [Article Type] Article
Role of ribosomal pathways and comorbidity in COVID-19: Insight from SARS-CoV-2 proteins and host proteins interaction network analysisResearch Article Published on 2024-04-192024-09-05 Journal: Heliyon [Category] update2024, [키워드] Comorbidity COVID-19 Drug repurposing Host interacting genes Ribosomal pathways SARS-CoV-2 proteins [DOI] 10.1016/j.heliyon.2024.e29967 PMC 바로가기 [Article Type] Research Article
Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agentsAnalytical Procedures Published on 2024-04-122024-09-05 Journal: Med Instrum [Category] update2024, [키워드] antiviral drug combinations concentration-dependent drug-drug interaction dose-response matrix Drug repurposing two-way pharmacodynamic modeling upstream drug-dependent pharmacodynamic parameters [DOI] 10.1128/aac.01015-23 PMC 바로가기 [Article Type] Analytical Procedures
Nonsmall-cell lung cancer treatment: current status of drug repurposing and nanoparticle-based drug delivery systemsResearch Article Published on 2024-04-032024-09-05 Journal: Turkish Journal of Biology [Category] update2024, [키워드] Drug repurposing nanoparticle-based drug delivery systems nonsmall-cell lung cancer NSCLC [DOI] 10.55730/1300-0152.2687 PMC 바로가기 [Article Type] Research Article
Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic IndicationsArticle Published on 2024-03-282024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] 16S rRNA-seq profiles bacterial co-infections bacterial key genes (bKGs) Bioinformatics analysis Drug repurposing SARS-CoV-2 infections [DOI] 10.3390/ph17040432 PMC 바로가기 [Article Type] Article