The Role of Viral Proteins in the Regulation of Exosomes BiogenesisArticle Published on 2021-05-132023-08-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] E형 간염, [키워드] biogenesis Exosomes Extracellular vesicles regulate virus [DOI] 10.3389/fcimb.2021.671625 PMC 바로가기
Cascading from SARS-CoV-2 to Parkinson’s Disease through Protein-Protein InteractionsArticle Published on 2021-05-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] appear cascade Central nervous system Clinical finding Cluster CNS connection coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Effect Exosome Exosomes expected explain expressed Extensive host protein host proteins human tissues hypothese Hypothesis include Interaction joint lung Lungs mechanism molecular mechanisms organs/systems Parkinson’s disease Parkinson’s disease Patient post-translational modification post-translational modifications Protein protein-protein interaction protein–protein interactions Proteins proteome provide random reported SARS-CoV-2 significantly significantly more supported Transport Trigger triggering Viral protein Viral proteins [DOI] 10.3390/v13050897 PMC 바로가기 [Article Type] Article
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment급성 호흡곤란 증후군에서 중간엽 줄기세포의 치료 기전은 Covid-19 치료의 가능성을 보여줍니다Review Published on 2021-05-102022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Adipose tissue administration adverse effect adverse effects Allogeneic analyzed animal experiments ARDS attenuate Bone marrow breath cell infusion cells Clinical studies clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine Cytokines Effects Endoplasmic reticulum Evidence Exosome Exosomes experiment fibrosis highlight inflammatory cells inhibit mechanism mesenchymal stem cell Mesenchymal stem cells modulate mortality rate MSC MSC therapy MSCs paracrine patients with ARDS pulmonary fibrosis raising recent respiratory distress severe COVID-19 stem cell Stress syndrome therapeutic tissue Treatment umbilical Umbilical cord [DOI] 10.1186/s12967-021-02862-x PMC 바로가기 [Article Type] Review
Commentary: Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 TreatmentImmunology Published on 2021-04-292022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Advanced therapies COVID-19 Exosomes New piece puzzle SARS-CoV-2 STEM stem cells [DOI] 10.3389/fimmu.2021.682195 PMC 바로가기 [Article Type] Immunology
The Significance of Phenotyping and Quantification of Plasma Extracellular Vesicles Levels Using High-Sensitivity Flow Cytometry during COVID-19 TreatmentCOVID-19 치료 중 고감도 유세포 분석을 사용한 혈장 세포외 소포 수준의 표현형 및 정량화의 중요성Brief Report Published on 2021-04-272022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD14+ CD146 CD147 CD19 CD19+ CD4+ CD63 CD8+ cell type cell types centrifugation clinical manifestation Concentration Coronavirus infection COVID-19 demonstrated diagnostics differential centrifugation dissemination Effectiveness EVs Exosomes extracellular vesicle Extracellular vesicles Flow flow cytometry high-sensitivity flow cytometry immunostaining Infection Level marker mechanism New Pathogenesis patients with moderate Phenotyping phenotyping extracellular vesicles plasma plasma extracellular vesicles Plasma level Plasma levels progression Quantitative analysis SARS-CoV-2 Severe infection severity Significance significantly increased therapy transfer Vesicle vesicles [DOI] 10.3390/v13050767 PMC 바로가기 [Article Type] Brief Report
MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreakReview Published on 2021-04-222022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory distress antiviral immune response candidate clinical status COVID-19 COVID-19 complication COVID-19 outbreak COVID-19 therapy ENhance Exosome Exosomes Gene therapy Immune suppression immunomodulatory involved lung management Mesenchymal stem cells miRNA MSCs pandemic Pathogenesis platform Prevent regenerative regimen RNA RNA interference SARS-CoV-2 SARS-CoV-2 pathogenesis siRNA syndrome target targets the SARS-CoV-2 therapeutic therapeutic option therapeutic strategy therapy Treatment viral spread Virus life cycle [DOI] 10.1186/s12967-021-02840-3 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human MicrogliaImmunology Published on 2021-04-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition Anomaly association axis bystander catastrophic CNS COVID-19 COVID-19 case declining deubiquitinase distress downstream dysfunction Exosome Exosomes explain expression gene product Host Host immune response Human Hyperactivation IFN-β immune cascade IRF9 knowledge microglia microRNA modify mRNA nervous Neuroinflammation neurological NF-κB Novel coronavirus infection organ pathway patients pro-inflammatory gene expression Protein provide regulate Replication SARS-CoV-2 shown Specific spike spike gene supported suppress syndrome System target target gene tissue TNFα transfected cell transported ubiquitin uninfected USP33 Vaccine Viral load virus [DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology
A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood코로나19에 감염된 말초혈액에서 차등적인 circRNA와 lncRNA 발현에 관한 연구Article Published on 2021-04-122022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] activities Apoptosis Biomarkers carried cell cycle Clinical genetics conducted COVID-19 COVID-19 infection COVID-19 patient COVID-19 virus database diagnostic differentially expressed Diseases enrichment analysis Exosome Exosomes expression Gene Expression genetic interaction healthy host cell immune immune tolerance infection mechanism Inflammation information involved KEGG life lncRNA mRNA outbreak pathway Peripheral blood Perspective recurrence Regulation reported sequenced Sequencing signaling pathway therapeutic Transmission Treatment [DOI] 10.1038/s41598-021-86134-0 PMC 바로가기 [Article Type] Article
RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving FieldReview Published on 2021-04-042022-10-31 Journal: Cancers [Category] COVID-19, [키워드] αvβ3 αvβ6 accumulated Angiogenesis approach approaches binding Cancer cancer progression Cell cells Clinical studies clinical trials compounds diagnostic disease dose elevated Exosomes expression fibrosis field function functions high accuracy integrin integrin targeted therapy Integrins investigated knowledge Ligand ligands Metastasis molecular molecular imaging motif non-cancerous novel nuclear optical other diseases patient selection pharmacological progression receptors respiratory RGD-binding integrins SARS-CoV-2 SARS-COV-2 infection selective Sepsis Signal transduction simple subtype Subtypes synthetic synthetic integrin ligands target therapeutic target therapeutic targets therapy translation translational Treatment protocol treatment strategy Trial vascular normalization therapy viral infections [DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review
COVID-19 in a lung transplant recipient: Exploring the diagnostic role of circulating exosomes and the clinical impact of advanced immunosuppression폐 이식 환자의 COVID-19: 순환 엑소좀의 진단 역할 및 고급 면역 억제의 임상 영향 탐색Case Reports Published on 2021-04-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] MERS, SARS, 진단, 치료기술, [키워드] Allograft allograft dysfunction Analysis antibodies Antigen cellular circulating exosome circulating exosomes clinical impact collagen COVID-19 detect diagnostic driven by dysfunction Exosome Exosomes female fluorescent intensity HLA HLA class II human leukocyte antigen Immunosuppression increase in Infection Injury leukocyte lung lung self antigens lung transplant mean fluorescent intensity Methylprednisolone Pathogens plasma recipient rejection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein self-antigen Spike protein Symptoms the mean the patient the SARS-CoV-2 treated tubulin Viral viral pathogens Viral protein Viral proteins [DOI] 10.1111/tid.13480 PMC 바로가기 [Article Type] Case Reports