PIMS-TS, the New Paediatric Systemic Inflammatory Disease Related to Previous Exposure to SARS-CoV-2 Infection—“Rheumatic Fever” of the 21st Century?SARS-CoV-2 감염에 대한 이전 노출과 관련된 새로운 소아 전신 염증 질환인 PIMS-TS - 21세기의 "류마티스 열"?Review Published on 2021-04-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] abnormal immune response acute respiratory syndrome acute respiratory syndrome coronavirus acute rheumatic fever Affect antagonists Anti-inflammatory anti-inflammatory treatment ARF article blockers can be used children coronavirus Course courses COVID-19 current current therapy disease Efficacy and safety exposure to feature Fever glucocorticoid Glucocorticoids IL-6 IL-6 receptor Immunoglobulin Inflammatory inflammatory disease interleukin intravenous Intravenous immunoglobulin management Necrosis New paediatric inflammatory multisystem syndrome paediatric inflammatory multisystemic syndrome (PIMS) pathogen Pathogenesis Pathogens Patient PIMS Prophylaxis question rheumatic fever SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Symptom syndrome systemic systemic inflammatory the vaccine therapy [DOI] 10.3390/ijms22094488 PMC 바로가기 [Article Type] Review
Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 RegistryArticle Published on 2021-04-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission Admissions age all-cause mortality Analysis antirheumatic agents Autoimmune disease Autoimmune diseases Barthel Index Biological biological therapy Clinical characteristics Clinical course Comorbidity complications Corticosteroid COVID-19 death decrease diagnosed with COVID-19 disease disease-modifying anti-rheumatic drug Effects Factor female General population Glucocorticoids greater Habitual hospitalized patient ICU immune system diseases in-hospital complications increased risk information intensive care invasive involved mechanical ventilation Mortality multivariate logistic regression Non-invasive Older outcome outcomes Patient patients patients with COVID-19 Poor Primary outcome Prognosis readmission registry SARS-CoV-2 secondary outcome selected Spanish subsequent Treatment variables Weighting with COVID-19 [DOI] 10.3390/jcm10091844 PMC 바로가기 [Article Type] Article
Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era글루코코르티코이드 수용체에 의한 전사 억제: 유전체학 시대를 위한 간결한 모델Review Published on 2021-04-212022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] anti-inflammatory drug clinical effectiveness coordination COVID-19 Effect enhancer enhancers Factor Factors Gene Expression Genes glucocorticoid Glucocorticoid receptor glucocorticoid receptor (GR Glucocorticoids GR, Glucocorticoid receptor GRE, glucocorticoid response element human disease Inflammation Inflammatory inflammatory transcription mechanisms molecular mechanisms monomer negative feedback NF-κB NF-κB signaling nGRE, negative glucocorticoid response element receptor regulated repression second Signaling subset target targets tissue repair Transcription transcription factors transcriptional transcriptional enhancer treat TSS, transcriptional start site widespread [DOI] 10.1016/j.jbc.2021.100687 PMC 바로가기 [Article Type] Review
Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19Review Published on 2021-04-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] angiotensin-converting enzyme inhibitor antiviral properties autophagy autophagy machinery Camostat mesylate can be used Chloroquine clinically Compound coronavirus CoV COVID-19 CoVs drug Effect effort endolysosomal system Glucocorticoids growth highlight host cell host cells Hydroxychloroquine identify in vitro in vivo infected with SARS-CoV-2 Infection inhibit lysosomotropic agents modulate modulator Mortality Patient Pharmacology Potential Prevent promote Protease inhibitor Protein proteolytic cleavage Rapamycin reducing Research risk SARS-COV-2 infection signaling pathways Stage Strategy treat umifenovir viral entry viral infection [DOI] 10.3390/ijms22084067 PMC 바로가기 [Article Type] Review
Glucocorticoids are double-edged sword in the treatment of COVID-19 and cancersReview Published on 2021-04-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] activities adjusted administration allergy backbone biological function Cancer Community cortical cell cortisone COVID-19 Critical Dexamethasone extension glucocorticoid Glucocorticoids help High-dose homeostasis Hormones Hydrocortisone increase Medicine Methylprednisolone occur organs Pain Patient Physiology Prednisolone Prednisone Prize PROTECT researcher secreted Severe infection Shock Side effect solid tumor Structure therapy trauma Treatment [DOI] 10.7150/ijbs.58695 PMC 바로가기 [Article Type] Review
Methylprednisolone in adults hospitalized with COVID-19 pneumonia : An open-label randomized trial (GLUCOCOVID)Randomized Controlled Trial Published on 2021-04-012022-10-05 Journal: Wiener Klinische Wochenschrift [Category] SARS, 임상, [키워드] 95% confidence interval Admission adults hospitalized Analysis assigned composite endpoint Corona Coronavirus infections Course COVID-19 COVID-19 patient death determine Evidence glucocorticoid Glucocorticoids had no humans IMPROVE intensive care intention-to-treat intravenous ITT ITT analysis mechanical ventilation Methylprednisolone Mortality Noninvasive ventilation Open-label outcome oxygen Patient per protocol performed Pneumonia PP analysis Primary outcome Randomized randomized trial receiving risk Sample size SARS-CoV-2 SARS-CoV‑2 screened Severe case significant effect significantly lower Standard of care suffered Support systemic inflammatory response the primary endpoint Trial with COVID-19 [DOI] 10.1007/s00508-020-01805-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumoniaControlled Clinical Trial Published on 2021-04-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 임상, 치료법, [키워드] adjusted adjusted hazard ratio Admission Anakinra anti-inflammatory treatment Anticoagulants Antiviral baseline cohort study Combination coronavirus disease covariates COVID-19 COVID-19 pneumonia Cox model Cytokine storm early treatment Efficacy Efficacy and safety evaluated glucocorticoid Glucocorticoids High dose Hydroxychloroquine IL-1 Inflammatory response intravenous intravenous methylprednisolone Mortality Patient patients patients with COVID-19 performed Pneumonia receive receiving reduced retrospective Severe COVID-19 pneumonia single-center Standard of care survival Tocilizumab Treatment were used [DOI] 10.1016/j.jaci.2021.01.024 PMC 바로가기 [Article Type] Controlled Clinical Trial
Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patientsArticle Published on 2021-04-012023-07-13 Journal: Annals of the rheumatic diseases [Category] SARS, [키워드] Autoimmune diseases biological therapy communicable diseases Glucocorticoids imported tumor necrosis factors. [DOI] 10.1136/annrheumdis-2020-218310 PMC 바로가기
What we have to know about corticosteroids use during Sars-Cov-2 infectionSars-Cov-2 감염 중 코르티코스테로이드 사용에 대해 알아야 할 사항Review Published on 2021-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] SARS, 치료제, [키워드] acute respiratory syndrome addition Adrenal Adrenal insufficiency affected antiretroviral drug antiretroviral drugs antiviral therapy available data caused co-morbidities concomitant treatments consequence Corticosteroid Corticosteroids cortisol COVID-19 COVID-19 outbreak Critical Critical illness dose drug drug interaction Drug interference drug withdrawal drug-drug interaction drugs ENhance exposure to gcs Glucocorticoid treatment Glucocorticoids HPA hypercortisolism hypoadrenalism impairment Infection Interaction involved literature management morbidities morbidity and mortality mortality risk pathway Patient physician risk SARS-CoV SARS-CoV 2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients secretion Severe acute respiratory syndrome Steroids Symptom therapy treat Treatment Withdrawal [DOI] 10.1007/s40618-020-01384-5 PMC 바로가기 [Article Type] Review
Precision therapeutic targets for COVID-19COVID-19에 대한 정밀 치료 표적Review Published on 2021-03-292022-09-10 Journal: Virology Journal [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antiviral drug antiviral drugs approved benefit caused convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 cough COVID-19 deaths demonstrated develop Dexamethasone disease domains drug drugs Dyspnea Effect Efficacy evaluate fatigue Fever General population Glucocorticoids High-dose Hospitalization hospitalized patients hypercoagulability individual infected with SARS-CoV-2 inhibiting less limitation M pro MPro main protease management multi-organ failure mutate myocarditis Pneumonia Pro protease proteolytic activation RdRP reducing mortality Remdesivir Replication respiratory respiratory distress RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Severe case severe cases Spike protein Spread subset supplementary material supportive care Symptom syndrome the SARS-CoV-2 the spike protein therapeutic target therapy Transcription Viral viral replication [DOI] 10.1186/s12985-021-01526-y PMC 바로가기 [Article Type] Review