Heart Failure Probability and Early Outcomes of Critically Ill Patients With COVID-19: A Prospective, Multicenter StudyCardiovascular Medicine Published on 2021-11-262022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% CI age albumin all-cause mortality analyzed applied assist bootstrap C-index cardiac function clinical suspicion coronavirus disease COVID-19 Critically ill patient enrolled failure Follow-up heart heart failure highlighting Ill IMPROVE In-hospital death laboratory-confirmed lymphocyte Mortality mortality rate multicenter multicenter study multivariate logistic regression nomogram NT-proBNP operator outcome Patient patients died predict Predictive predominant Primary outcome Probability Prognosis Prospective Prospective Study risk factor risk stratification screened significantly higher the patient total bilirubin unlikely with COVID-19 zone [DOI] 10.3389/fcvm.2021.738814 PMC 바로가기 [Article Type] Cardiovascular Medicine
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19확장된 최소 침습적 부검: COVID-19의 심폐 사건 조사를 위한 기술 개선Original Article Published on 2021-11-172022-09-10 Journal: Clinics [Category] MERS, SARS, 치료기술, [키워드] Accuracy alternative Autopsy biopsies can be used Cardiopulmonary contagious COVID-19 died Diseases eight evaluated event events Evidence Extended feasible flexible heart human diseases improvement Infectious diseases invasive limitation Lungs Minimally Invasive Autopsy Myocardial infarction organ pandemic pathophysiology Patient Post-mortem post-mortem biopsy sampling technique Thoracic Thromboembolism tissue tissue sample Ultrasound vessels was performed [DOI] 10.6061/clinics/2021/e3543 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissuesSARS-CoV-2 감수성과 COVID-19 질병 중증도는 다양한 조직에서 유전자 발현에 영향을 미치는 유전적 변이와 관련이 있습니다Article Published on 2021-11-162022-09-11 Journal: Cell Reports [Category] SARS, 변종, 유전자 메커니즘, [키워드] affecting association Brain causal SNP Colocalization COVID-19 COVID-19 disease COVID-19 disease severity digestive system disease severity disease severity of COVID-19 eight eQTL eQTL. eQTLs expression expression quantitative trait loci Factors Gene Expression gene expression level Genetic genetic factors Genetic variant Genome Genome-wide association study genomic genomic loci GWAS heart identify immune system individual loci lung muscle Quantitative SARS-CoV-2 SARS-CoV-2 susceptibility skin SNP Symptom tissue Variability variant variants variety variety of tissue [DOI] 10.1016/j.celrep.2021.110020 PMC 바로가기 [Article Type] Article
Organ-specific genome diversity of replication-competent SARS-CoV-2복제 가능 SARS-CoV-2의 장기 특이적 게놈 다양성Article Published on 2021-11-162022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Asymptomatic clinical microbiology coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 treatment death died disease Evolution Evolution of SARS-CoV-2 extrapulmonary organ extrapulmonary organs fatal disease Genome heart highlighting hygiene identify Immunocompromised patient Immunocompromised patients Impact Infection information kidney lead liver lung Lungs measure multiple organ multiple organs Mutation N501Y nucleotide organ organ-specific organs Pathogenesis plasma proof provide replicate Replication replication-competent SARS-CoV-2 reported respiratory respiratory symptom respiratory symptoms Respiratory system resulting SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Single nucleotide variant spleen Stage Still systemic manifestation the patient Treatment variants variants of concern Vero E6 VERO E6 cells Viral Viral load viral loads viral pathogenesis Viremia Virological virus infectivity VOCs Y453F [DOI] 10.1038/s41467-021-26884-7 PMC 바로가기 [Article Type] Article
Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management제2형 당뇨병의 심부전: 선별, 진단 및 관리에 대한 현재의 관점Review Published on 2021-11-062022-09-10 Journal: Cardiovascular Diabetology [Category] MERS, 바이오마커, 진단, [키워드] alterations approved bases Cardiomyopathy Chronic kidney disease complex COVID-19 severity criteria diabete diabetes Diagnosis gold gold standard guidelines heart heart failure highlight individual Kidney disease management myocardial damage NT-proBNP pathology pathophysiology Perspective pharmacological Prevalence risk factor Risk factors Stressor therapy Type type 2 diabete type 2 diabetes [DOI] 10.1186/s12933-021-01408-1 PMC 바로가기 [Article Type] Review
The Pathogenesis of COVID-19 Myocardial Injury: An Immunohistochemical Study of Postmortem BiopsiesImmunology Published on 2021-11-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute phase Analysis Apoptosis apoptotic cell arrythmia Autopsy biopsy caspase-1 caspase-9 CD163 collagen control group controls COVID-19 COVID-19 patients COVID-19 sample died edema endothelial Endothelium expression fibrosis heart hearts histological ICAM-1 IHC IL-1β IL-4 IL-6 immunohistochemistry increased expression Injury interstitial invasive involved less local inflammation marker mast cell mechanism monoclonal antibody Mortality Myocardial Myocardial dysfunction myocardial injury Myocardium not differ objective Pathogenesis pathogenesis of COVID-19 pathology pathway Patient performed positive Postmortem rationale Result SARS-CoV-2 significantly staining Surveillance TGF-β TNF-α was performed [DOI] 10.3389/fimmu.2021.748417 PMC 바로가기 [Article Type] Immunology
Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography계층적 위상차 단층 촬영을 사용하여 세포 구조의 국소 분해능으로 온전한 인간 장기 이미징Article Published on 2021-11-042022-09-12 Journal: Nature methods [Category] MERS, SARS, 진단, [키워드] applied Brain Cardiovascular biology Cell cellular cellular resolution cellular structure changes in coronavirus disease Coronavirus disease 2019 COVID-19 Deceased dimension Donor equipment European facility FIVE followed by functional healthy heart Hierarchical human kidney imaging kidney Local lung morphological feature organ organs provided quantification Source spleen Synchrotron radiation tissue tomography Translational research Volume X-ray X-ray tomography [DOI] 10.1038/s41592-021-01317-x PMC 바로가기 [Article Type] Article
Analysis of Apps With a Medication List Functionality for Older Adults With Heart Failure Using the Mobile App Rating Scale and the IMS Institute for Healthcare Informatics Functionality Score: Evaluation StudyOriginal Paper Published on 2021-11-022022-10-31 Journal: JMIR mHealth and uHealth [Category] Coronavirus, MERS, SARS, [키워드] app store average Care changes conducted COVID-19 pandemic criteria Efficiency evaluated Evidence example failure feature Features function Google Play Health heart heart failure highest IMS inclusion criteria informatics Ireland list lowest management managing medication medication app medication history mHealth Mobile Mobile App Mobile App Rating Scale MOST objective Older outpatient consultation professional Record reducing researcher Result Satisfaction scale scored Support tested vital parameter was used [DOI] 10.2196/30674 PMC 바로가기 [Article Type] Original Paper
Safety and heart rate changes in Covid-19 patients treated with Remdesivir렘데시비르 치료를 받은 코로나19 환자의 안전성 및 심박수 변화Case Reports Published on 2021-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] administration Analysis arrhythmia Arrhythmias baseline bradycardia cardiac rhythm cardiovascular cardiovascular comorbidities Cardiovascular Toxicity Case series case sery changes in clinical complication COVID-19 COVID-19 patients ECG examination heart heart rate less Limited Multivariate analysis occurred Occurrence Patient patients patients treated patients with COVID-19 reduction reduction in Remdesivir Safety severe bradycardia Toxicity treated was related [DOI] 10.1016/j.ijid.2021.09.036 PMC 바로가기 [Article Type] Case Reports
Vaccinating adolescents against SARS-CoV-2 in England: a risk–benefit analysisResearch Published on 2021-11-012022-10-30 Journal: Journal of the Royal Society of Medicine [Category] COVID-19, MERS, SARS, [키워드] Admission Admissions Analysis assumption benefit calculated carried center children clinical Control COVID death dose Efficacy Electronic health records England estimate evidence-based practice foundation heart hospital Hospital admission hospitalisation incidence intensive care unit methodology myocarditis National Non-clinical objective offer outcome outcome measure paediatrics participant public health Quantitative Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV2 Science setting Support Vaccinating vaccination vaccination programmes Vaccine [DOI] 10.1177/01410768211052589 PMC 바로가기 [Article Type] Research