Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species인간과 다른 종의 ACE2에 대한 박쥐 코로나바이러스 RaTG13 바이러스의 결합 및 분자적 기초Article Published on 2021-06-242022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus animal reservoirs binding carried complex continuous surveillance coronavirus COVID-19 CoVs cross-neutralize cross-reactive antibody evaluated global pandemic hACE2 horseshoe bat Host host range Human human ACE2 induce intermediate horseshoe bat intermediate horseshoe bat. mAb mechanism molecular basis monoclonal antibody phylogenetically Prevent pseudovirus RaTG13 RBD Receptor binding Receptor binding domain reservoir residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance the SARS-CoV-2 variants variants of concern virus VOCs [DOI] 10.1016/j.cell.2021.05.031 PMC 바로가기 [Article Type] Article
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus originSARS-COV-2 스파이크 단백질 -ACE2 결합 친화력의 SILICO 비교에서 종에 대한 바이러스 기원에 대한 영향Article Published on 2021-06-242022-09-10 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] ACE2 affinity analyses angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 approach binding binding affinity can be used caused Chemistry Computational biology and bioinformatics Computational chemistry correlation COVID-19 pandemic Diseases docking Drug discovery enzyme exhibited explain ferret generate hACE2 help helping highest highest binding affinity highlight human ACE2 humans hydrogen Hydrogen bond hydrogen bonds implication in silico Infection information mechanism molecular dynamics Molecular dynamics simulation much lower novel virus Novel viruses pangolin power predict predicted Protein question raised respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 spike sequence sequence homology sequence similarity shown Small molecules spike Spike protein structural biology structural homology susceptibility tested transfer Transmission vectors virus viruses [DOI] 10.1038/s41598-021-92388-5 PMC 바로가기 [Article Type] Article
Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell–cell fusionResearch Published on 2021-06-232022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 293T A549 ACE2 administration Affect angiotensin-converting enzyme 2 assays binding Cell Cell fusion Cell hybrid cell line cell membrane co-culture Combination combinations COVID-19 Deletion downstream Ebola Effect event expressed expressing expressing S protein expression vectors Formation global pandemic hACE2-expressing cell HIV host cell host cell receptor human ACE2 human cell line implication in vitro assays infecting Interaction investigated mechanism motif mRNA mRNA vaccine mutated nuclear occur parameters Protein reduce reported Result S protein SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein SARS-CoV-2 vaccine Spike protein Structure supplementary material Syncytia syncytia formation the S protein the SARS-CoV-2 virus tissue tissue damage transduced Vaccine variant virus wild-type [DOI] 10.1186/s13578-021-00626-0 PMC 바로가기 [Article Type] Research
SARS‐CoV‐2 first contact: Spike–ACE2 interactions in COVID‐19Commentary Published on 2021-06-212022-10-31 Journal: Chemical biology & drug design [Category] COVID-19, MERS, SARS, [키워드] ACE2 AT1 complex COVID‐19 domain human ACE2 Interaction SARS‐CoV‐2 [DOI] 10.1111/cbdd.13898 PMC 바로가기 [Article Type] Commentary
Atomistic De-novo Inhibitor Generation-Guided Drug Repurposing for SARS-CoV-2 Spike Protein with Free-Energy Validation by Well-Tempered Metadynamics원자체 de-Novo 억제제 생성 유도 약물 용 약물 용도가 잘 정기 된 메타 아이미믹스에 의한 자유 에너지 검증을 갖는 SARS-COV-2 스파이크 단백질을위한 약물 용도.Article Published on 2021-06-142022-08-31 Journal: Chemistry, an Asian journal [Category] MERS, SARS, 신약개발, 치료제, [키워드] applied approach approved binding calculated conditions COVID-19 de novo de Novo drug design disease docking drug drug candidate drug design drugs experiments free energy Free energy calculations hACE2 human ACE2 increasingly Metadynamics molecular molecular dynamics RBD receptor Receptor binding domain repurposing repurposing therapeutics SARS-CoV-2 similarity spike Spike protein Spike proteins validation Viral viral spike protein viral spike proteins well-tempered metadynamics. [DOI] 10.1002/asia.202100268 PMC 바로가기 [Article Type] Article
A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2Pharmacology Published on 2021-06-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 approach approved binding candidate Compound COVID-19 COVID-19 treatment disrupting docking drug drug screen effective highlight human ACE2 identify inhibit inhibited inhibition assay inhibitor Interaction International IP-FCM Nilotinib offer Oxytocin receptor ACE2 regulatory agency Repurposed SARS-CoV-2 spike protein Screen screened spike Spike protein spike-ACE2 the SARS-CoV-2 Thiostrepton trimeric [DOI] 10.3389/fphar.2021.685308 PMC 바로가기 [Article Type] Pharmacology
Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone인간 카텔리시딘은 SARS-CoV-2 감염을 억제합니다: 하나의 돌로 두 마리의 새 죽이기Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Adenovirus administration affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 antimicrobial peptide association bind Bird blockade Cathelicidin Cell coronavirus disease Coronavirus disease 2019 COVID-19 decrease domain enzyme expressing half-maximal inhibitory concentration high affinity Host Human human ACE2 in vitro Infection inhibit inhibitor Interaction Invasion Lung infection mechanisms mice peptide Protein RBD Receptor binding Receptor binding domain Receptor-binding domain recruitment SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike Stone subsequent targeting the RBD the receptor-binding domain Treatment [DOI] 10.1021/acsinfecdis.1c00096 PMC 바로가기 [Article Type] Article
V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity초기 전파 단계에서 나타나는 SARS-CoV-2 스파이크 RBD의 V367F 돌연변이는 증가된 인간 ACE2 수용체 결합 친화도를 통해 바이러스 감염성을 향상시킵니다Virus-Cell Interactions Published on 2021-06-022022-09-10 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis analyzed angiotensin assays binding binding affinity caused circulating coronavirus CoV COVID-19 COVID-19 pandemic Critical domain dominant dominant mutations drug ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Genome genomes hot spot Human human ACE2 human Angiotensin-converting enzyme humans in silico Increased indicated infect infectious Infectivity MDs molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutant Mutation nonsynonymous Novel coronavirus pandemic of COVID-19 pangolin pangolin CoV phase Phylogenetic analysis provide Pseudotyped virus RBD RBD mutation RBD mutations receptor Receptor binding Receptor-binding domain (RBD) Recombination Research respiratory SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 RBD SARS-CoV-2 spike protein SARS-CoV-2 variant selection pressure severe acute respiratory syndrome Coronavirus spike spike mutation spike mutations Spike protein Support surface plasmon surface plasmon resonance Surveillance sustained the RBD the SARS-CoV-2 trajectory Transmission V367F Vaccine Vaccines variant variants Viral viral infectivity viral tropism zoonotic infections zoonotic origin [DOI] 10.1128/JVI.00617-21 PMC 바로가기 [Article Type] Virus-Cell Interactions
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice자가 전사 및 복제 RNA 기반 SARS-CoV-2 백신의 단일 용량은 마우스에서 보호 적응 면역을 생성합니다Article Published on 2021-06-022022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] adaptive alphavirus amplify Anti-spike Antibody titers CD4 CD8 Cell-mediated immunity complex conventional mRNA coronavirus COVID-19 cytokine dose ENCODE expression full-length spike glycoprotein glycoprotein human ACE2 IgG1 IL-4 immune response Immunity Immunoglobulin Immunoglobulin G Infection interferon interleukin Interleukin-4 intracellular cytokine staining LUNAR-COV19 lymphocyte Lymphocytes mice Mortality Neutralizing antibody titer neutralizing antibody titers Prevent produced Protective replicon RNA RNA-based SARS-CoV-2 vaccine robust antibody responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein self-amplifying RNA single dose spike glycoprotein STARR supported T helper T lymphocyte response the SARS-CoV-2 transgenic mice translation vaccination Vaccine Viral wild-type SARS-CoV-2 [DOI] 10.1016/j.ymthe.2021.04.001 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 Spike Protein/ACE2 Protein-Protein Interactions: a Computational StudySARS-CoV-2 스파이크 단백질/ACE2 단백질-단백질 상호작용 표적화: 전산 연구Article Published on 2021-06-012022-09-11 Journal: Molecular informatics [Category] SARS, 치료제, [키워드] ACE2 Analysis angiotensin angiotensin converting enzyme approach binding COVID-19 docking Drug discovery effective entry of SARS-CoV-2 enzyme host cell host cells human ACE2 Infection inhibit inhibitor machine learning approaches occur PPI PPI focused library protein-protein interaction protocol QSAR RBD Receptor binding Receptor binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 virus spike spike glycoprotein starting point subsequent Support targeting the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic target Treatment Virtual screening virus entry was selected Zinc ZINC database [DOI] 10.1002/minf.202060080 PMC 바로가기 [Article Type] Article