IL-2 – Page 14 – Communicable Diseases Research

Advances in immunotherapy for COVID-19: A comprehensive review

Review

Published on 2021-01-222022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 치료제,

Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection

항체와 사이토카인 생산의 상호작용으로 CXCL13이 치명적인 SARS-CoV-2 감염의 잠재적인 신규 바이오마커로 밝혀짐

Research Article

Published on 2021-01-202022-09-10
Journal: mSphere [Category] 바이오마커, 진단, 치료법,

[키워드] Activation age Alpha Analysis analyzed anti-SARS-CoV-2 antibody antibodies antibody antibody level antibody levels Antigen antigens B cell Biomarker Blood blood type chemokine chemokine CXCL13 chemotactic marker chemotactic markers Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 virus CXCL13 cytokine Cytokine analysis cytokine response Cytokines develop disease disease severity elevated Eotaxin exhibited explain gamma interferon Germinal center healthy individuals help identify IFN-γ IL-12 IL-18 IL-2 IL-4 IL-6 IL-8 immune immune response immune system Immunity immunological Immunological response Increases increases in Infection information interferon interleukin interleukin 6 involved IP-10 knowledge lethal magnitude majority marker maturation MIP-1α Necrosis novel nucleocapsid outcomes Patient patient mortality patients who survived populations Potential produced Production proinflammatory Protein provide RANTES RBD Receptor binding domain S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 immunity SARS-CoV-2 pandemic SARS-CoV-2 patient SARS-CoV-2 patients severe COVID-19 Sex significant level specificity specimens systemic immune response TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha Variation Viral Viral proteins
[DOI] 10.1128/mSphere.01324-20 PMC 바로가기 [Article Type] Research Article

An immune-based biomarker signature is associated with mortality in COVID-19 patients

면역 기반 바이오마커 시그니처는 COVID-19 환자의 사망률과 관련이 있습니다

Research Article

Published on 2021-01-112022-09-10
Journal: JCI Insight [Category] 바이오마커, 진단, 치료제,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Biomarker biomarker signature Biomarkers Blood CCL2 Cell cells chemokines Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical CXCL9 Cytokines died Discordance disease disease severity ferritin Hospitalization IFNA2 IL-10 IL-15 IL-1α IL-2 IL-6 immune immunology Inflammatory Inflammatory response Italian patient lactoferrin Mortality multivariable analysis multivariate multivariate analyses outcome Patient predict produced Protein respiratory S100A9 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity ST2 trajectory transcript level transcriptional type I Type I IFN type I IFNs type II IFN utility with COVID-19
[DOI] 10.1172/jci.insight.144455 PMC 바로가기 [Article Type] Research Article

The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus

사이토카인 프로필과 면역 반응은 제2형 당뇨병을 가진 COVID-19 환자에서 증가합니다

Comparative Study

Published on 2021-01-022022-09-10
Journal: Journal of Diabetes Research [Category] 바이오마커,

The plausible mechanisms of tramadol for treatment of COVID-19

COVID-19 치료를 위한 트라마돌의 그럴듯한 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법,

[키워드] ACHE activate Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant therapy age Anti-inflammatory anti-inflammatory effect antioxidant antitussive approved C-reactive protein caused clinical outcomes clinical trials Complication coronavirus coronavirus disease coronavirus disease-2019 correlated cough COVID-19 COVID-19 patient COVID-19 patients CRP cytokine Cytokine storm dependence disease dismutase drug Effect effective elevated ENhance enzyme Evidence FIBRIN glutathione Glutathione peroxidase headache help hypocoagulable Hypocoagulable effect IL-2 Immune-enhancing increase Increases interleukin lack Lactate lactate dehydrogenase LDH lead less malondialdehyde management mechanism mechanism of action medication moderate moderate to severe Mortality Multiple natural killer Necrosis old age oxidative damage Pain pathogen Pathogens patients patients with COVID-19 peroxidase Pneumonia polymerization PROTECT Pseudomonas aeruginosa psychiatric disorder Psychiatric disorders recent respiratory respiratory depression Respiratory failure SARS-CoV-2 SARS-COV-2 infection secretion severe COVID-19 patient severe COVID-19 patients severe pain severity Superoxide Superoxide Dismutase Support suppress T-cell T-cells therapeutic option therapy for COVID-19 thrombosis TNF-α tramadol Tramadol. Treatment treatment of COVID-19 patients tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Venous Thromboembolism
[DOI] 10.1016/j.mehy.2020.110468 PMC 바로가기 [Article Type] Review

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial

Detection and analysis of clinical features of patients with different types of coronavirus disease 2019

다양한 유형의 코로나바이러스 질환 환자의 임상 특징 탐지 및 분석 2019

Article

Published on 2021-01-012022-09-11
Journal: Journal of medical virology [Category] Fulltext, MERS, 치료기술,

[키워드] addition Affiliated Hospital Analysis analyzed Blood blood cell Blood routine cholesterol clinical feature Clinical features collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 detection diagnosis of COVID-19 disease severity hypertension IL-2 IL-4 induce information kidney Laboratory laboratory index liver Liver function Lymphocytes Medicine moderate Myocardial Neutrophils Older Patient patients patients with COVID-19 progression proportion proportions School severe COVID-19 Severe patient severity Severity of disease significantly higher suggested Symptoms the disease Total cholesterol university White blood cell Zhejiang
[DOI] 10.1002/jmv.26225 PMC 바로가기 [Article Type] Article

HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients

Immunology

Published on 2020-12-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] Anti-viral Antibody Response CD4+ cell CD4+ T cell CD4+ T cells CD8+ cell Cell characterized common variable immunodeficiency disorder (CVID) Coronavirus disease 2019 (COVID-19) correlation COVID-19 cross-reactive cross-reactivity CVID detectable Endemic evaluate evaluated Evidence Frequency had no HCoV-229E healthy control healthy individuals human endemic coronavirus 229E (HCoV-229E) human endemic coronavirus OC-43 (HCoV-OC43) IFNγ IL-2 Immunity less marker multifunctional nucleocapsid pathogen Patient patients patients with CVID peptide pools primary immunodeficiency (PID) profiles Protective Proteins provide raised reactive reactivity reported risk SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity T cell T cell response T cell responses TNFα virus
[DOI] 10.3389/fimmu.2020.607918 PMC 바로가기 [Article Type] Immunology

The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular System

Cardiovascular Medicine

Published on 2020-12-092022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome alleviate appear ARDS attenuate Cardiac arrhythmia cardiovascular cardiovascular complications cardiovascular system cause caused Cell clinical study Complication coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 positive patient CXCL10 Cytokine storm deaths develop drug Effect elevated global pandemic hallmark heart help IL-2 IL-22 IL-6 IL-7 immune system immunomodulatory Immunosuppression induced infected case Infection lung Mesenchymal stem cells Mortality MSC MSCs myocardial injury myocarditis organ systems Patient Prevent primary site pro-inflammatory cytokine regeneration and repair role SARS-CoV-2 Severe case shown storm stromal cell suggested syndrome System the cytokine storm therapy Thromboembolism tissue repair TNFα
[DOI] 10.3389/fcvm.2020.602183 PMC 바로가기 [Article Type] Cardiovascular Medicine

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

더 나쁜 결과를 초래할 수 있는 심각한 COVID-19 폐렴에서 조절되지 않는 선천성 면역 반응

Controlled Clinical Trial

Published on 2020-12-032022-08-13
Journal: Journal of Translational Medicine [Category] MERS, SARS, 임상,

[키워드] acute respiratory distress syndrome Analysis baseline CCL20 CCL5 Characteristics classical clinical coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 cytokine cytokine response Cytokines dysregulated dysregulated immune response enrolled G-CSF GM-CSF IL-10 IL-15 IL-1β IL-2 IL-6 IL-8 immune modulation immune response Immunopathogenesis Inflammatory cytokine Inflammatory cytokines innate immune response intensive care mechanical ventilation multivariate regression analysis Non-COVID-19 non-COVID-19 and COVID-19 patients non-COVID-19 patient Non-COVID-19 patients outcome outcomes plasma plasma concentration plasma concentrations Pneumonia Principal component principal component analysis required respiratory respiratory severity Result severe COVID-19 Severe COVID-19 pneumonia severe pneumonia significantly single center T cell T cell phenotype T-cell exhaustion target TGF-β therapeutic therapeutic targets TNF-α unique
[DOI] 10.1186/s12967-020-02646-9 PMC 바로가기 [Article Type] Controlled Clinical Trial