A review on the induction of host immunity by the current COVID-19 vaccines and a brief non-pharmaceutical intervention to mitigate the pandemicReview Published on 2022-02-162022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] Abstract antiviral drug approach approaches avoidance cellular COVID-19 pandemic COVID-19 severity COVID-19 situation COVID-19 vaccine effective Genetic global public health Health host immunity humoral immune response Intervention knowledge MERS-CoV Middle East mitigate Non-pharmaceutical interventions pandemic platform positive result present Protective Respiratory Coronavirus respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants second wave similarity the SARS-CoV-2 vaccination Vaccine Vaccine development Vaccines variants variants of SARS-CoV-2 viral escape while [DOI] 10.1186/s42269-022-00719-x PMC 바로가기 [Article Type] Review
Literature Review of Omicron: A Grim Reality Amidst COVID-19Review Published on 2022-02-162022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antibody binding B.1.1.529 Cell-mediated immunity Characteristics concern Coronaviridae Coronavirus disease 2019 COVID-19 Epidemiology evade globe immune response literature MERS-CoV monoclonal antibodies Mutation occurred omicron Protein REALITY respiratory review SARS-CoV SARS-CoV-2 South Africa strain Transmissibility Vaccines variant VoC Wuhan [DOI] 10.3390/microorganisms10020451 PMC 바로가기 [Article Type] Review
In Silico Prediction and Selection of Target Sequences in the SARS-CoV-2 RNA Genome for an Antiviral AttackArticle Published on 2022-02-142022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, SARS, [키워드] 229E alternative methods analyzed Antiviral antiviral drugs Antiviral strategies antiviral strategy approaches attack conserved contribute Coronaviruses COVID-19 CRISPR-Ca CRISPR-Cas13d effective HKU1 human coronavirus humans MERS-CoV Molecular biology NL63 nucleotide OC43 omicron outbreak Pandemics performed prediction protective vaccine provide related viruses replicate RNA RNA interference Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 isolates SARS-CoV-2 pandemic screened Selection sequence target the SARS-CoV-2 the SARS-CoV-2 genome unique variant [DOI] 10.3390/v14020385 PMC 바로가기 [Article Type] Article
hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAsCoronaviruses Published on 2022-02-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] activate acute respiratory syndrome airway analysed Analysis biogenesis Calu-3 Calu-3 cell cells circRNA co-expression cognitive coronavirus Critical downstream epithelial expression facilitate form heterogeneous hnRNP C Host human lung immunoprecipitation increase Infection Interaction knockdown MERS-CoV MERS-CoV infection Messenger RNA Middle East modulate mRNA mRNAs mTOR inhibitor nuclear OSI-027 Pathogenesis pathway phosphorylated physically reduced viral loads Replication respiratory syndrome coronavirus ribonucleoprotein RNA RNA binding protein SARS-CoV-2 SARS-CoV-2 replication shown significantly Specific subset suppressed systemically upregulated viral infections virus [DOI] 10.1080/22221751.2022.2032372 PMC 바로가기 [Article Type] Coronaviruses
MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granulesResearch Article Published on 2022-02-062022-10-28 Journal: Virulence [Category] COVID-19, [키워드] Act Actinomycin Analysis Antigen presentation Cell Cell migration cells cellular complex death downregulated downregulating explain Genes Granule impair Inflammatory inhibit LLPS Lysosomes mass spectrometry mechanism MERS-CoV MERS-CoV infection metabolic processe metabolic processes Middle East mRNA non-structural protein nsp1 oxidative phosphorylation P-bodies Protein Regulatory respiratory syndrome coronavirus ribosomal protein ribosome RNA sensitivity Sequencing shown stress granule stress granules transcriptional transgenic mice upregulated viability [DOI] 10.1080/21505594.2022.2032928 PMC 바로가기 [Article Type] Research Article
Hidden fraction of Polish population immune to SARS-CoV-2 in May 20212021년 5월에 SARS-CoV-2에 면역된 폴란드 인구의 숨겨진 부분Research Article Published on 2022-02-032022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Anti-RBD IgG anti-SARS-CoV-2 antibodies Antigen antigens Asymptomatic can not collected convalescent COVID-19 COVID-19 pandemic cross-reactivity diagnosed estimation exclusion fraction HCoV HCoV 229E healthy individual healthy individuals herd immunity hospitalized COVID-19 patient hospitalized COVID-19 patients IgA IgA antibodies IgA antibody IgG immune Immunity individual Infection infections investigated Lower majority MERS-CoV modeling NL63 other coronaviruses pandemic Patient patients Population population immunity Population screening positive positive controls Protein public health Quantitative RBD Registered SARS-CoV SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2-specific IgG sera serum sample serum samples spike subject tested vaccination vaccination against COVID-19 Vaccinations virus virus-neutralizing Virus-specific IgG [DOI] 10.1371/journal.pone.0253638 PMC 바로가기 [Article Type] Research Article
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cellsResearch Article Published on 2022-02-022022-10-30 Journal: Life Science Alliance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Analysis both viruses carried Cell cellular change changed changes in contribute Coronavirus infection COVID-19 patients disseminate distal driving Effect epithelial cell host cell host cell response human donor infected with SARS-CoV-2 Infection innate immune activation kidney Kidney injury MERS-CoV MERS-CoV infection mitochondrial modulation molecular mechanism Mortality pathology pathway Prevent protein quality control proteome proteomics proximal Quantitative renal renal epithelial cell SARS-CoV-2 SARS-COV-2 infection shared pathway tubular cell viral replication virus [DOI] 10.26508/lsa.202201371 PMC 바로가기 [Article Type] Research Article
Identification of cytotoxic T cells and their T cell receptor sequences targeting COVID-19 using MHC class I-binding peptidesMHC 클래스 I 결합 펩타이드를 사용하여 COVID-19를 표적으로 하는 세포독성 T 세포 및 T 세포 수용체 서열 확인Article Published on 2022-02-022022-09-10 Journal: Journal of Human Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antigen Brazil CD8 cellular immunity characterized China clone conserved coronavirus COVID-19 CTL CTLs Cytotoxic T cell cytotoxic T lymphocyte cytotoxic T lymphocytes elicited Epitopes glycoprotein histocompatibility complex HLA-A HLA-A*02:01 HLA-A*02:06 human leukocyte antigen identification identify Immunity India individual individuals induce investigated leukocyte Lymphocytes maintain major histocompatibility complex membrane membrane glycoprotein MERS-CoV MHC MHC class Neutralizing antibodies neutralizing antibody nine non-infected ORF1 ORF1ab other coronavirus other coronaviruses pandemic peptide peptide epitope peptide epitopes peptides Peripheral blood peripheral blood samples polyprotein Protein recognize reported respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 viral sequence Sequencing severe acute respiratory syndrome Coronavirus South Africa Spike protein T cell T cell receptor T cell response T cell responses T cells TCR sequence TCR sequences TRA TRB unique United Kingdom Vaccinations variant Viral proteins [DOI] 10.1038/s10038-022-01013-4 PMC 바로가기 [Article Type] Article
Evolution of Viral Pathogens Follows a Linear OrderResearch Article Published on 2022-02-022022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, 신종인플루엔자, [키워드] acute respiratory syndrome addition Amino acid Analysis contribute coronavirus coronavirus disease COVID-19 dengue virus determine distribution Evidence Evolution H1N1 H3N2 HCoV-229E HCoV-NL63 HCoV-OC43 Infectious disease influenza A linear linear order MERS MERS-CoV Microbiology Middle East outbreak Outbreaks predict random reveal SARS-CoV SARS-CoV-2 serotype shown subsequent syndrome triggering Vaccine variants of concern viral family viral genome viral mutation viral pathogen virus Zaire Zika [DOI] 10.1128/spectrum.01655-21 PMC 바로가기 [Article Type] Research Article
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19COVID-19 퇴치를 위한 단일 입자 극저온 전자 현미경의 공헌Review Published on 2022-02-012022-09-12 Journal: Trends in biochemical sciences [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 antibodies binding COVID-19 cryo-EM Effective vaccines enzyme feature interactions intrinsic MERS-CoV Microscopy molecular molecular dynamics neutralizing antibody receptor Receptor-binding domain SARS-CoV-2 Spike protein the spike protein virus [DOI] 10.1016/j.tibs.2021.10.005 PMC 바로가기 [Article Type] Review