RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiotaRS-5645는 폐 미생물총을 조절하여 SARS-CoV-2 스파이크 단백질 및 LPS에 의해 유도된 염증성 사이토카인 폭풍을 약화시킵니다Research Paper Published on 2021-07-252022-09-10 Journal: International Journal of Biological Sciences [Category] SARS, 바이오마커, [키워드] 16S rRNA 4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone (RS-5645) abundance Activation addition alveolar alveoli Amino acid amino acid metabolism Analysis attenuate biogenesis cause of death CD11b CD45 CD56 CD56+ cellular COVID-19 patients Critically ill cytokine death elevated exhibited expression Host IFNγ indicated Inflammatory inflammatory cell inflammatory cell infiltration inflammatory cells Inflammatory cytokine Inflammatory cytokine storm inflammatory factor storm inflammatory storm inhibited Intervention involved KEGG LPS lung tissue manifested metabolism metabolite mice microbiota microorganism microorganisms modulating mononuclear cell mononuclear cells mRNA mRNAs overlapping Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Protein pulmonary microbiota qPCR reduce reduced Research rRNA S protein SARS-CoV-2 (COVID-19) spike protein SARS-CoV-2 spike SARS-CoV-2 spike protein Secondary Metabolite severely and critically ill COVID-19 patients significantly Streptococcus the S protein the SARS-CoV-2 translation unique [DOI] 10.7150/ijbs.63329 PMC 바로가기 [Article Type] Research Paper
Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In VivoArticle Published on 2021-07-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 activity acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding blockade blocked clinical outcomes commensal bacteria coronavirus correlated COVID-19 cytokine cytokine expression cytokine production endotoxin exhibited host cell immune responses Impact in vitro induce inducer induction Infection inflammatory cytokine production inhibited inhibitor Interaction Like LPS mechanism MERS Middle East modeling mononuclear cell mucosal tissue Neutralizing pathogenic pathway PBMC Peripheral blood Potential Proinflammatory cytokine promote reagent reagents reported respiratory SARS CoV-2 soluble ACE2 spike Spike protein variable [DOI] 10.3390/ijms22147540 PMC 바로가기 [Article Type] Article
Longitudinal Analysis of Human Memory T-Cell Response According to the Severity of Illness up to 8 Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증급성호흡기증후군 코로나바이러스 2 감염 후 최대 8개월까지 질병의 중증도에 따른 인간 기억 T 세포 반응의 종단 분석Article Published on 2021-07-022022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 치료법, [키워드] 8 months acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen Asymptomatic Asymptomatic disease CD4+ T cell CD4+ T-cell coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cytometry analysis Flow cytometry analysis Frequency greater healthy volunteer healthy volunteers Human illness Longevity longitudinal membrane membrane protein memory memory response memory T-cell response Mild Mild disease mononuclear cell mononuclear cells Month nucleocapsid Patient patients with COVID-19 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells persist post-symptom onset protective effect protective immunity PSO Reinfection respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe disease severity severity of illness T cell T cells T-cell T-cell Response T-cell responses understanding vaccination with mild disease [DOI] 10.1093/infdis/jiab159 PMC 바로가기 [Article Type] Article
HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis만성 B형 간염에 대한 치료 백신인 HeberNasvac은 선천 면역의 국소 및 전신 표지자를 자극합니다: SARS-CoV-2 노출 후 예방에 잠재적 사용Article Published on 2021-07-012022-09-11 Journal: Euroasian J Hepatogastroenterol [Category] 비임상, [키워드] Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral properties antiviral property both sexes breath CHB chronic chronic hepatitis Chronic Hepatitis B clinical trial Cohort coronavirus coronavirus disease COVID-19 Dengue died Disease progression dose enrolled evidenced expression functional Hepatocellular carcinoma immune cells Immunity immunomodulating immunomodulatory immunomodulatory effect impairment increased expression Innate innate immune cell Innate immune cells Innate immunity intranasal lethal infection Local Lymphocytes malignancies malignancy marker material mice monocyte Monocytes mononuclear cell nasopharyngeal Older Open-label pandemic Patient patients PBMC Peripheral blood periphery Postexposure Postexposure Prophylaxis Potential presenting prophylactic therapy Prophylaxis randomized clinical trial reduction in respiratory infections Result Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown subjects surrogate markers Symptom symptoms of COVID-19 systemic the patient therapeutic therapy Toll-like receptor Toll-like receptors tonsils Treatment Vaccine [DOI] 10.5005/jp-journals-10018-1344 PMC 바로가기 [Article Type] Article
SARS-CoV-2 specific T-cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex vivo ELISpot assay코로나19 회복기 환자 및 노출되지 않은 대조군의 SARS-CoV-2 특이적 T 세포 면역성을 생체외 ELISpot 분석으로 측정Article Published on 2021-07-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] accompany CD4 CD4 T cells CD8 T cell characterized Cohort Control convalescent Coronaviruses COVID-19 COVID-19 convalescent patient COVID-19 infection Donor ELISPOT ELISpot assay Ex vivo humoral Humoral response immune protection Infection median mononuclear cell Neutralizing antibodies neutralizing antibody Patient PBMCs Peripheral blood positive positive correlation positive response positive result quantified SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 neutralizing antibodies serum samples subject subjects Symptom symptom onset T-cell immunity T-cell Response the SARS-CoV-2 titre undetectable uninfected was performed [DOI] 10.1016/j.cmi.2021.03.010 PMC 바로가기 [Article Type] Article
Self-prescribed Ivermectin use is associated with a lower rate of seroconversion in health care workers diagnosed with COVID, in a dose-dependent response자가 처방 Ivermectin 사용은 용량 의존적 반응에서 COVID로 진단된 의료 종사자의 낮은 혈청 전환율과 관련이 있습니다Article Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 진단, 치료기술, [키워드] abdominal pain age antibody Brazil Clinical efficacy Cohort consequence COVID COVID-19 cross-sectional cross-sectional study cytokine Cytokines diagnosed diagnosed with COVID-19 diarrhea disease severity dose dose-dependent drug Effectiveness evaluate the effect evaluated Evidence groups HCW Health care Health care worker health care workers immune response immunomodulatory effects Impact impairment in vitro increasingly Ivermectin lack less mechanism mononuclear cell mononuclear cells multiple dose multiple doses Neutralizing antibodies neutralizing antibody Pain participant Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells Professor purified rate of seroconversion Reinfection reported risk SARS-CoV-2 SARS-CoV-2 treatment Seroconversion Side-effect Spike protein stimulated stratified Treatment treatment of COVID-19 women [DOI] 10.1016/j.bjid.2021.101603 PMC 바로가기 [Article Type] Article
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial우간다 신생아의 이종 감염성 질환에 대한 BCG- 유도 비특이적 영향 : 조사관 맹인 무작위 대조 시험Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 1:1 Abstract addition age all-cause mortality Alter analysed analyses assigned BCG BCG vaccination benefit Birth blind block size block sizes blood sample Blood samples change clinically clinician Comparisons computer-generated Concentration Consent contributed Controlled Controlled trial Cord blood discharged Effect Effects eligible enrolled Entebbe Families finding Follow-up for inclusion funding geometric geometric mean geometric mean ratios gestational age group hazard ratio healthy hepcidin Heterologous hospital IFNγ IL-10 IL-1β IL-6 IL1B IL6 immunological incidence increase in Infant Infants infections Infectious disease inhibited Innate immunity international standard investigated investigators life Luganda material medical intervention modified intention-to-treat mononuclear cell morbidity morbidity and mortality mother Neonatal neonatal period no significant difference non-specific number outcome parent parents participant Peripheral blood Peripheral blood mononuclear cells primary clinical outcome promoter promoter region PROTECT randomisation randomised randomised controlled trial Randomly receive recruited reduce reductions reductions in Registered required saturation Standard Standard dose stratified by sex TNF Transferrin translation Trial Tuberculosis Uganda vaccination Wellcome Trust were excluded with HIV withdrawn [DOI] 10.1016/S1473-3099(20)30653-8 PMC 바로가기 [Article Type] Articles
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral InfectionSARS-CoV-2 바이러스 감염 중 자가항원 발현 향상Immunology Published on 2021-06-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation Analysis Asymptomatic COVID-19 autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity Autopsy bioinformatics Blood conducted confirmed case confirmed cases COVID-19 COVID-19 infections datasets determine Effect enhanced evaluate expression level expression levels follow-up studies follow-up study homeostasis IFIH1 Immune homeostasis immunopathology in-silico Infection infections lead longitudinal low-density lung lung autopsies mononuclear cell mononuclear cells MPO neutrophil neutrophil activation overexpressed PADI4 PBMCs Peripheral blood Peripheral blood mononuclear cells plasma protein protein level protein levels PRTN3 PTPRN2 respiratory viral infection SAR-CoV-2 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 infections severity of COVID-19 significantly single-cell dataset subset tissue Tolerance transcriptomic TRIM21 TSHR upregulated upregulation Viral viral infection viral infections Whole blood [DOI] 10.3389/fimmu.2021.686462 PMC 바로가기 [Article Type] Immunology
Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning기계 학습을 사용하여 디코딩된 COVID-19 심각도 및 만성의 면역 기반 예측Immunology Published on 2021-06-282022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activated T cells Activation activities analyzed approach B-cell bioinformatics CCL3 CCL4 CCR5 CD14+ CD16+ CD4 CD8 characterized chemokines Classifier continuum COVID COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient cytokine Cytokines dataset defined disease dysregulated effective effector T cell elevated excessive inflammation expressing generate GM-CSF healthy control healthy controls identify IFN-γ IL-10 IL-2 IL-4 IL-6 IL-8 immune response implicated individual individuals induce investigated Ligand machine learning Model mononuclear cell PASC Patient PBMCs Peripheral blood plasma positive predict prediction pro-inflammatory random recruitment second significantly significantly lower subset Symptoms T cell activation T-cell T-regulatory cell treatment strategy VEGF virus while [DOI] 10.3389/fimmu.2021.700782 PMC 바로가기 [Article Type] Immunology
H-Ras gene takes part to the host immune response to COVID-19Perspective Published on 2021-06-252022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] affected Cancer Comparative analysis condition COVID-19 COVID-19 patient COVID-19 patients downregulated expression Gene Expression Gene expression analysis Host immune response independent datasets mononuclear cell mutated Patient PBMC performed Peripheral blood Predictive markers SARS-COV-2 infection SARS-CoV-2 virus infection severe disease significantly upregulated upregulation viral infection was performed [DOI] 10.1038/s41420-021-00541-w PMC 바로가기 [Article Type] Perspective