N501Y – Page 14 – Communicable Diseases Research

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

면역 탈출 변이체 추적을 위한 SARS-CoV-2 RBD 특이적 중화 항체의 결합 핫스팟에 대한 포괄적인 매핑

Research

Published on 2021-10-142022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] accumulation ACE2 binding additive effect Alanine Amino acid antibody antibody escape mutant Antibody-mediated neutralization antigenic antigenic site antigenic sites B.1.351 B.1.617.1 binding binding affinity changes in characterized circulating Comprehensive convalescent individual convalescent individuals convalescent plasma COVID-19 described determinant determinants domain E484K early stage escape mutation Escape variants Evidence Evolution F486L facilitate Host host immunity immune Immune escape impair independent K417N L452R memory B cell memory B cells Mutation N501Y NAb NAbs natural mutation neutralization Neutralizing antibodies neutralizing antibody not affect pandemic provide pseudoviruses RBD RBD antigenic sits RBD mutation RBD-specific antibody reactive Receptor-binding domain Recombinant protein recombinant proteins Result SARS-CoV-2 selected single B cell specific antibodies strain supplementary material Surveillance the RBD Treatment treatment of COVID-19 variant variants variants of SARS-CoV-2 virus was performed
[DOI] 10.1186/s13073-021-00985-w PMC 바로가기 [Article Type] Research

Shared Mutations in Emerging SARS-CoV-2 Circulating Variants May Lead to Reverse Transcription-PCR (RT-PCR)-Based Misidentification of B.1.351 and P.1 Variants of Concern

신종 SARS-CoV-2 순환 변이체의 공유 돌연변이로 인해 우려되는 B.1.351 및 P.1 변이체의 역전사-PCR(RT-PCR) 기반 오식으로 이어질 수 있음

Observation

Published on 2021-10-132022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단,

[키워드] B.1.351 Candidates concern COVID-19 E484K evaluated identify misidentification Mutation mutations N501Y P.1 PCRs reverse transcriptase PCR RT-PCR RT-PCRs SARS-CoV-2 SARS-CoV-2 variant Sequencing variants VoC WGS whole-genome sequencing
[DOI] 10.1128/Spectrum.00816-21 PMC 바로가기 [Article Type] Observation

Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity

바이러스 감염에 대한 SARS-CoV-2 변이체 N501Y.V1 및 N501Y.V2 스파이크의 특성화

Cellular and Infection Microbiology

Published on 2021-10-132022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종,

[키워드] antiviral immunity B.1.1.7 B.1.351 characterization contribute coronavirus disease Coronavirus disease 2019 COVID-19 D614G demonstrated drug Efficiency endocytosis evade Host Infection Infectivity inhibitor inhibitors Mutation N501Y N501Y.V1 N501Y.V2 pathogen protease Protein pseudotype pseudovirus raised reported S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variants sensitivity South Africa spike Spread stability stomatitis thermal stability United Kingdom variant variants vesicular stomatitis vesicular stomatitis virus virion virus wildtype
[DOI] 10.3389/fcimb.2021.720357 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Hidden in Plain Sight: Natural Products of Commensal Microbiota as an Environmental Selection Pressure for the Rise of New Variants of SARS-CoV-2

잘 보이지 않는 곳에 숨겨져 있음: SARS-CoV-2의 새로운 변종 증가를 위한 환경 선택 압력으로서 공생 미생물군의 천연 산물

Review

Published on 2021-10-132022-09-11
Journal: Chembiochem [Category] SARS, 변종,

Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization

10개의 신흥 SARS-CoV-2 스파이크 변이체는 가변 감염성, 동물 친화성 및 항체 중화를 나타냅니다.

Article

Published on 2021-10-132022-09-10
Journal: Communications Biology [Category] MERS, SARS, 변종, 진단,

[키워드] activities activity Alpha Amino acid antibody Antibody neutralization antigenicity B.1.1.7 B.1.351 B.1.429 B.1.525 B.1.526 Beta Calu Calu-3 calu-3 cells cathepsin L caused cell lines cells convalescent serum COVID-19 pandemic E484K E484K mutation elicited Epsilon furin highlight host tropism Immune escape infect K417N L452R monoclonal antibodies Mutation N501Y neutralization neutralized Patient provide pseudovirus RBD Receptor-binding domain reduction in S477N SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum Seven significantly increased the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies TMPRSS2 Vaccine Vaccines variant variants viral infection Y453F Zeta
[DOI] 10.1038/s42003-021-02728-4 PMC 바로가기 [Article Type] Article

Evolution of SARS-CoV-2 Key Mutations in Vienna Detected by Large Scale Screening Program

대규모 스크리닝 프로그램에 의해 검출 된 비엔나에서 SARS-COV-2 주요 돌연변이의 진화

Brief Report

Published on 2021-10-072022-09-01
Journal: Viruses [Category] MERS, SARS, 변종, 진단, 치료기술,

Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617

Microbiology

Published on 2021-10-072022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] acute respiratory syndrome amino acid change analyzed B.1.617 B.1.617.2 binding ability Biological biological significance circulating coronavirus country COVID-19 pandemic Deletion Dynamics Follow-up Frequency genetic diversity Genome genomic variation Haplotype Haplotype network increasingly India indicated involved L452R lifted Lineage measure molecular evolution mutant Mutation N501Y nonstructural proteins P681R pandemic Positive selection predominant prevalent reported SARS-CoV-2 sequence sequenced Significance Single nucleotide polymorphism SNPs Spread Structural analysis structural proteins Substitution tertiary structure the S protein the vaccine tracing variant viral genome
[DOI] 10.3389/fmicb.2021.750725 PMC 바로가기 [Article Type] Microbiology

Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants

Immunology

Published on 2021-10-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677H

Q677H 보유 관련 SARS-CoV-2 변종 중화

Observation

Published on 2021-10-052022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

SARS-CoV-2 Genomic Sequencing Revealed N501Y and L452R Mutants of S/A Lineage in Tianjin Municipality, China

SARS-CoV-2 게놈 시퀀싱, 중국 톈진 시에서 S/A 계통의 N501Y 및 L452R 돌연변이 밝혀

Article

Published on 2021-10-012022-09-11
Journal: Virologica Sinica [Category] SARS, 변종, 유전자 메커니즘,

[키워드] China L452R municipality N501Y Revealed SARS-CoV-2 Tianjin
[DOI] 10.1007/s12250-021-00432-5 PMC 바로가기 [Article Type] Article