Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by DexamethasoneOriginal Article Published on 2021-04-162022-10-30 Journal: Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced [DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individualsSARS-CoV-2에 대한 IL-33 발현은 COVID-19 회복기 개인의 혈청 양성과 상관관계가 있습니다Article Published on 2021-04-092022-09-12 Journal: Nature Communications [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age anti-SARS-CoV-2 antibody anti-Spike IgG Antibody titer Asthma BALF Bronchoalveolar lavage fluid CD14 CD4 Cell cells chronic disease Chronic diseases Cohort convalescent convalescent individual convalescent individuals COPD coronavirus COVID-19 COVID-19 pathogenesis days post-infection disease severity Effect elicit Epidemiology expression Fever glycoprotein IFNA2 IL-1β IL-23 IL-33 IL-6 immune immune response immune responses Immunity increase Infection Interleukins Mild Monocytes observational study Pathogenesis Patient PBMC PBMCs PCR peptide produced Pulmonary infection recall reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein scRNAseq seronegative seropositive seropositive individuals Seropositivity Seropositivity for SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus severe COVID-19 spike spike glycoprotein spike IgG subject subset Symptoms T cell T cell activation the disease their family member their family members TLR7 TNF virus [DOI] 10.1038/s41467-021-22449-w PMC 바로가기 [Article Type] Article
Acute and post-acute phase of COVID-19: Analyzing expression patterns of miRNA-29a-3p, 146a-3p, 155-5p, and let-7b-3p in PBMCComparative Study Published on 2021-04-062022-10-04 Journal: International immunopharmacology [Category] MERS, 바이오마커, [키워드] acute COVID-19 acute respiratory syndrome addition Analysis appear assays Biomarker cellular miRNA characteristic coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 patient COVID-19 patients COVID‐19 demonstrated Diagnosis diagnosis and monitoring disease evaluated expression level expression pattern groups healthy information microRNA miRNA miRNA expression miRNA profile mononuclear cell pathogen PBMC PBMCs Peripheral blood Real-time PCR Result ROC ROC analysis SARS-CoV-2 selected sensitivity significantly significantly higher specificity suggested the disease the healthy was tested [DOI] 10.1016/j.intimp.2021.107641 PMC 바로가기 [Article Type] Comparative Study
Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignanciesResearch Published on 2021-04-012022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] acute phase addition Analysis analyzed approach CD3+ CD38 CD4+ CD79B CD8+ T cells change clinical disease Coagulation coexistent consecutive patients coronavirus disease (COVID-19) correlated correlation count COVID-19 COVID-19 patient COVID-19 patients Critical CyTOF cytokine Cytometry demonstrated Differentially expressed genes disease effector memory expressed expression First wave Gene expression profiling group Hematological malignancies Hematological malignancy Hospitalized Host immune response IFIT3 IL-6 Immune cell immune response indicate Inflammation intensive care unit involved IP-10 leukemia LIPI Low T3 syndrome marker mononuclear cell multiplex NanoString NLR NLRP3 outbreak Patient patients with COVID-19 PBMC performed Peripheral blood Pneumonia presenting radiologic reduced reduction reported Result Rome SARS-CoV-2 serum Serum level serum levels severe COVID-19 severity single-cell SOFA subtype supplementary material syndrome T lymphocytes target gene the disease thyroid function tissue damage TSS university [DOI] 10.1186/s12967-021-02805-6 PMC 바로가기 [Article Type] Research
Human coronaviruses in idiopathic Parkinson’s disease: Implications of SARS-CoV-2’s modulation of the host’s transcriptome특발성 파킨슨병의 인간 코로나바이러스: SARS-CoV-2의 숙주 전사체 조절의 의미Article Published on 2021-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] among others analyses Analysis comparison Control coronavirus determine disease Diseases Effect enriched pathways enrichment analyses enrichment analysis false discovery rate FDR Gene Expression Gene ontology Gene Set Enrichment Analyses GSEA head Head-to-head comparisons Host Human human coronavirus human coronaviruses Huntington's disease immune response indicated modulation mononuclear cell motor nucleus mRNA NAFLD neurodegeneration neurodegenerative Neuroinvasive nigra not limited Ontology overlap overlapping parasitism parkinson s disease Parkinson's Disease Pathogenesis pathway Patient PBMC performed Peripheral blood Perturbation retrieved SARS-CoV-2 SARS-COV-2 infection scrutiny statistically significant substantia substantia nigra Surveillance tissue tissues Transcriptome transcriptomic Whole blood [DOI] 10.1016/j.meegid.2021.104733 PMC 바로가기 [Article Type] Article
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signalinglncRNA Snhg1-Vps13D 소포 트래피킹 시스템은 IL-7 신호 전달의 이중 효과 조절을 통해 메모리 CD8 T 세포 확립을 촉진합니다Article Published on 2021-03-242022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] acute viral infection Adaptive immunity Blimp1 CD8 CD8 T cell CD8 T cells Cell Cell Biology conserved convalescent COVID-19 patients differentiation Effect expression expression pattern Human IL-7 IL7R indicated Infection lncRNA mechanism membrane memory memory formation mice Non-coding RNAs pandemic pathogen pathogen-specific PBMC performed persistence promote Protein recent regulated Reinfection RNA Signaling Snhg1 STAT3 subset survival T cell T cells TCF7 transcriptional vaccination Vesicle viral infection Vps13D [DOI] 10.1038/s41392-021-00492-9 PMC 바로가기 [Article Type] Article
Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19말초 혈액 단핵 세포의 리소좀 활성화와 COVID-19에서 순환하는 LC3B의 예후적 의미Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, [키워드] Activation adjusted adjusted odds ratio age Analysis Asymptomatic autophagy Biomarker circulating clinical risk Concentration coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID-19 COVID-19 patient COVID-19 patients decrease Degradation deregulated disease Hospital admission Hospitalization increased the risk independent independent of LC3B light chain Logistic regression analyses Logistic regression analysis lysosome microtubule-associated protein Mild moderate-to-severe COVID-19 mononuclear cell mononuclear cells Mortality oxygen Oxygen therapy p62 pathway Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells prognostic respiratory Respiratory Support Serum concentration serum concentrations Sex significantly lower Spread SQSTM1 Supplemental oxygen therapy Transcriptome transcriptome analysis upregulation ventilatory [DOI] 10.1093/bib/bbab043 PMC 바로가기 [Article Type] Article
Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids인간 기관지 오르가노이드의 SARS-CoV-2 감염 중 관련 허브 유전자 발현의 탐색 및 검증Genome Database Published on 2021-03-162022-09-10 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] 3D structure model acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed Bioinformatics analysis bronchial organoid CCL2 CCL5 coronavirus COVID-19 CXCL1 CXCL10 CXCL8 Cytokines DEGs differentially expressed gene Differentially expressed genes downloaded downregulated gene EGF exploration expressed expression feasibility FGF2 FN1 Gene Expression Gene ontology Genes genomes GEO Health help high mortality hub genes Human bronchial organoids human bronchus ICAM1 identify IL1B IL6 immune response in vitro model Infection infection mechanism infection rate Interaction KEGG Kyoto Microarray MMP9 mRNA mRNA expression Novel coronavirus Novel coronavirus infection pandemic Pathogenesis pathway Pathways patients PBMC PBMCs Potential treatment PPI prognostic protein-protein interaction Protein–protein interaction R software respiratory Result SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus significantly suggested System three-dimensional structure Treatment upregulated gene were used [DOI] 10.1186/s40246-021-00316-5 PMC 바로가기 [Article Type] Genome Database
COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disordersCOVID-19 환자 전사체 및 게놈 프로파일링은 정신 장애와의 동반 질환 상호 작용을 나타냅니다Article Published on 2021-03-152022-09-10 Journal: Translational Psychiatry [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] affected analysed Analysis Anti-inflammatory Bipolar disorder causes co-expression Comorbidity comparison conditions correlated COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset disorder exacerbate gene cluster gene clusters Gene Expression Genome-wide association study genomic GWAS highlight Human behaviour identify immune immune responses immune system in some Infection inflammatory pathway interact Interaction Medical genetics medication mononuclear cell mononuclear cells Neuron neuronal neurons Ontology overlapped pathway Pathways Patient patients PBMC performed Peripheral blood Peripheral blood mononuclear cells Post-traumatic stress disorder profile Psychiatric psychiatric disorder Psychiatric disorders Psychiatric symptom Psychiatric symptoms PTSD reveal SARS-COV-2 infection Schizophrenia Support susceptibilities symptomatic targets transcript Transcriptome transcriptomic Treatment Usage Whole-genome sequence with COVID-19 [DOI] 10.1038/s41398-020-01151-3 PMC 바로가기 [Article Type] Article
Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID‐19–associated Guillain‐Barré syndrome생물정보학 분석은 COVID-19 관련 길랑-바레 증후군의 중심 기전으로서 증강된 T 헬퍼 17 세포 분화 및 사이토카인 반응을 암시Original Article Published on 2021-03-102022-09-10 Journal: Cell Proliferation [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities Activation Algorithm Analysis analyzed association autoimmune attack autonomic Bioinformatic CD86 cell differentiation Cluster Clustering conditions COVID‐19 COVID‐19 CSF2 cytokine cytokine response databases demonstrated disease disease entity DisGeNET Evidence Genes Genetic Guillain‐Barré syndrome IL10 IL1B IL23A IL27 IL2RA IL4 IL6 Interaction ISG20 ITGAM knowledge Macrophage Markov material mechanism mononuclear cell mononuclear cells network analysis objective parameter pathophysiological mechanism pathway Patient PBMC performed Peripheral blood Peripheral blood mononuclear cells peripheral nerves platform PTGS2 Regulatory regulatory genes required Result retrieved risk SARS‐CoV‐2 shown STRING subset suggested syndrome T helper Th17 TNF Transcriptome transcriptome analysis Version was used [DOI] 10.1111/cpr.13024 PMC 바로가기 [Article Type] Original Article