Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approachResearch Published on 2020-07-072022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] active site active sites anti-polymerase drug Antiviral antiviral drug approach clinical trials Compound coronavirus Drug discovery Galidesivir Health homology modeling in vitro in vivo inhibit Keeping molecular docking outbreak pandemic Phylogenetic tree potential therapeutic target predicted raised RdRP regulate reported Result RNA-dependent RNA polymerase SARS viruses SARS-CoV-2 shown similarity targeting therapeutic drug therapeutic option urgency viral infection viral outbreak viral replication Virtual screening Whole-genome sequence Wuhan, China [DOI] 10.1186/s12967-020-02439-0 PMC 바로가기 [Article Type] Research
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19Review Published on 2020-07-052022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] affecting Antiviral apoptotic autophagy autophagy pathway canonical canonical autophagy cellular complex coronavirus Coronavirus replication Coronaviruses COVID-19 detrimental disease drug identify inducer Infection inhibitor innate immune responses Interaction knowledge margin modulation molecular molecular mechanism noncanonical autophagy other diseases pathway Potential potential therapeutic target previous study Protective Proteins recent SARS-CoV-2 SARS-CoV-2 pandemic Still target Treatment turn viral infections viral replication virus [DOI] 10.3390/cells9071619 PMC 바로가기 [Article Type] Review
Insights into Potential Mechanisms of Injury and Treatment Targets in COVID-19, SARS-Cov-2 InfectionArticle Published on 2020-06-202022-10-30 Journal: International journal of clinical research & trials [Category] COVID-19, [키워드] Acute kidney injury acute respiratory syndrome Cardiac manifestation clinician coronavirus COVID-19 disease Healthcare system help insight kidney Lungs morbidity and mortality multiorgan failure Organ failure pandemic Pathogenesis pathophysiology Potential potential therapeutic target reported Research researcher SARS-CoV-2 SARS-COV-2 infection searched Spread target virus Wuhan [DOI] 10.15344/2456-8007/2020/147 PMC 바로가기 [Article Type] Article
SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapyReview Published on 2020-06-122022-10-28 Journal: Theranostics [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression ACE2 receptor Activation and animal model Ang II Angiotensin 1-7 animal model cardiac function cellular Coagulation cough COVID-19 COVID-19 pandemic COVID-19 pathogenesis Critical curtail death develop died Diffuse alveolar damage downregulate Effect entry receptor enzyme epithelial cell expressed feature Fever global public health help human cells immune cells implication infected individual Infection Interaction kidney lung multiple organ multiple organ failure Pathogenesis pathogenic pathway Patient Platelets Pneumonia post-mortem lung potential therapeutic target prevention of COVID-19 progression promote RAS receptor renin-angiotensin system Research reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic severe COVID-19 Shortness of breath Significant Spike protein the disease the S protein therapy tissue Treatment understanding vascular endothelial cell virus while with COVID-19 [DOI] 10.7150/thno.48076 PMC 바로가기 [Article Type] Review
SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary InflammationArticle Published on 2020-04-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated Analysis Antiviral agents binding activity CCL5 chemokine coronavirus CXCL10 demonstrated Diffuse alveolar damage domain epithelial cell examined expression G-quadruplex human lung in vitro indicated infiltration Inflammatory response inhibitor initiate Lung injury lung tissue macrodomain Macrophage mice modulated Monocytes NLRP3 NLRP3 inflammasome plasmids potential therapeutic target protein 3 pulmonary pulmonary inflammation respiratory SARS pathogenesis SARS-coronavirus SARS-CoV SARS-CoV unique domain (SUD), CXCL10 significantly Symptoms triggered unique up-regulated wild type [DOI] 10.3390/ijms21093179 PMC 바로가기 [Article Type] Article
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoVReview Published on 2020-04-132022-10-31 Journal: European Journal of Clinical Microbiology & Infect [Category] COVID-19, SARS, [키워드] ACE2 addition Angiotensin-converting enzyme Angiotensin-converting enzyme 2 (ACE2) caused coronavirus COVID-19 Diagnosis drug explain help Infection Inflammation inhibit Multiple organ damage New coronavirus New coronavirus (COVID-19) outbreak physiological physiological change Pneumonia potential therapeutic target Research SARS coronavirus (SARS-CoV) SARS-CoV subsequent target cell therapeutic strategy Treatment virus Wuhan, China [DOI] 10.1007/s10096-020-03883-y PMC 바로가기 [Article Type] Review
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver diseaseMitochondrial Amidoxime Reducing Component 1 유전자의 missense 변이와 간 질환에 대한 보호Research Article Published on 2020-04-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Alanine Alanine transaminase alkaline phosphatase allele Blood blood cholesterol level Blood level blood levels carrier carriers cause of death cholesterol cirrhosis coding variant cohorts component computed tomographic Control death deficiency eight enzyme exhibit fat Fatty liver Genetic genetic finding genetic findings hepatic fat homozygous identify individual LDL cholesterol liver Liver disease liver enzyme loss-of-function MARC1 Missense missense variant mitochondrial phosphatase potential therapeutic target predicted PROTECT reduced reduced risk Total cholesterol variant [DOI] 10.1371/journal.pgen.1008629 PMC 바로가기 [Article Type] Research Article
Acute lung injury in patients with COVID‐19 infectionShort Communication Published on 2020-03-312022-10-31 Journal: Clinical and Translational Medicine [Category] COVID-19, [키워드] acute lung injury acute respiratory distress alleviate approved ARDS China Clinical data clinicians and researchers consequence COVID‐19 COVID‐19 infection COVID‐19 decrease diagnosed edema effective Evidence Festival glucocorticoid Hypoxemia indication infected patients Local lung edema Lung injury mechanical ventilation Mortality Novel coronavirus outbreak Oxygen therapy Panic Patient potential therapeutic target Prognosis pulmonary inflammation radiologic required spring Support syndrome transmitted Treatment Ventilation WHO [DOI] 10.1002/ctm2.16 PMC 바로가기 [Article Type] Short Communication
Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)Editorial Published on 2020-03-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome adhesion Analysis angiotensin-converting enzyme-2 atlas China collected COPD COVID-19 death rate Electronic cigarettes expected fatality female Heat-Not-Burn Indonesia IQOS Iran Italy likelihood male males microbial infections much lower novel Older outbreak Potential potential therapeutic target receptor reported Research Respiratory Coronavirus respiratory viruses SARS-CoV SARS-CoV-2 Site smoker smoking smoking status South Korea Tobacco vaping virus [DOI] 10.3390/jcm9030841 PMC 바로가기 [Article Type] Editorial
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogasterDrosophila melanogaster의 식이 의존성 요산 병리학에서 인슐린 유사 신호 전달 경로의 보존된 역할Research Article Published on 2019-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting AKT2 arising association Author benefit candidate gene cascade changes in chronic disease Chronic diseases clinical Clinical studies component components conserved Coronary artery Coronary artery disease correlation Degradation diabetes disease disorders downstream Drosophila Drosophila melanogaster drug target Effect elevated expression Factor FOXO3 Genetic Gout Human humans Hyperuricemia hyperuricosuria insulin kidney kidney stone kidney stones knockdown mechanism metabolic syndrome metabolism modulating Multiple NADPH NADPH oxidase norm obesity Occurrence opens Pathogenesis Pathologies pathology pathway phenotype plethora potential therapeutic target potential therapeutic targets Protein purine purines raise reduced Regulatory rescued Research respond risk factor serum shown Signaling signaling pathway SNP SNPs sugar Support syndrome to define treat uric acid Urine vascular disorder yeast extract [DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article