Potential treatment – Page 14 – Communicable Diseases Research

Anti-inflammatory potential of Quercetin in COVID-19 treatment

Hypothesis

Published on 2021-01-282022-10-29
Journal: Journal of Inflammation (London, England) [Category] COVID-19,

[키워드] active form acute lung injury acute respiratory distress affected affecting Anti-inflammatory antioxidant bat coronaviruses Betacoronavirus complexes condition consequence COVID-19 cytokine Cytokine storm cytosolic DAMPs death determine Effect excessive inflammation generate IL-18 IL-1β include Inflammatory less life-threatening multiple organ dysfunction NLRP3 inflammasome Nrf2 patients patients with COVID-19 Pneumonia Potential treatment quercetin responsible risk factor SARS-CoV SARS-CoV-2 severe inflammation similarity SIRT1 suppresse syndrome the disease the SARS-CoV-2 virus Treatment TXNIP
[DOI] 10.1186/s12950-021-00268-6 PMC 바로가기 [Article Type] Hypothesis

Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-Analysis

Medicine

Published on 2021-01-272022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets

SARS-CoV-2 약물 가능 표적을 인식하는 자연 발생 화합물에 대한 최신 업데이트

Review

Published on 2021-01-262022-09-10
Journal: Molecules [Category] MERS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach approaches benzoquinones China clinical trial clinical trials Compound coronavirus COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients current data set drug Drug repurposing effective effort etiologic agent experimental evidence flavonoids Health in silico in vitro in vivo in-silico In-vitro inhibit investigated Medicine multi-targeting natural products Naturally outbreak Potential treatment Prevent recognizing recruited required Research respiratory SARS-CoV-2 SARS-COV-2 infection Scientific community severe acute respiratory syndrome Coronavirus Spread target targets therapeutic Transmissibility treat virus
[DOI] 10.3390/molecules26030632 PMC 바로가기 [Article Type] Review

Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy

Review

Published on 2021-01-222022-10-28
Journal: Viruses [Category] COVID-19,

Early Physical Therapist Interventions for Patients With COVID-19 in the Acute Care Hospital: A Case Report Series

Case Report

Published on 2021-01-192022-10-29
Journal: Physical therapy [Category] COVID-19,

[키워드] adopted Anxiety Awake prone positioning breathing exercise Care Case report case sery Clinical management complex COVID-19 COVID-19 pandemic Critical care Critical illness Critically ill delirium Dysphagia Early Ambulation Early mobilization hospital Hospital stay Impact indication intensive care limit Lung function management Most patient objective pandemic Patient patients patients with COVID-19 physical Physical therapist Physiotherapy Potential treatment prone positioning ranged rehabilitation report required Research respiratory symptom Result Sery Switzerland Symptom Therapeutic strategies therapist therapy Tolerance treated patient Treatment Treatment strategies weakness with COVID-19
[DOI] 10.1093/ptj/pzaa194 PMC 바로가기 [Article Type] Case Report

SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress

Physiology

Published on 2021-01-152022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] activate Atherosclerosis cardiovascular cardiovascular disease cause Cell chronic chronic conditions chronic inflammation COVID-19 disease EndMT Endothelial cell endothelial cells Endothelial dysfunction endothelial function exacerbate excess feedback loop Health Host implication Inflammation Inflammatory inflammatory pathway initiated long-term change Lung injury Mediated mitochondrial mitochondrial dysfunction oxidative stress Pathologies pathway phenotype Potential Potential treatment promote reactive oxygen specy redox status regulate role SARS-CoV-2 SARS-COV-2 infection senescence Signaling Stress thrombosis Vascular
[DOI] 10.3389/fphys.2020.605908 PMC 바로가기 [Article Type] Physiology

Missing clinical trial data: the evidence gap in primary data for potential COVID-19 drugs

누락된 임상 시험 데이터: 잠재적인 COVID-19 약물에 대한 기본 데이터의 증거 격차

Research

Published on 2021-01-152022-09-10
Journal: Trials [Category] 신약개발, 임상, 치료제,

Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study

퀘르세틴, 코로나19 유발 급성 신장 손상 치료제로서의 가능성: 네트워크 약리학 및 분자 도킹 연구 기반

Research Article

Published on 2021-01-142022-08-13
Journal: PLoS ONE [Category] 유전자 메커니즘,

[키워드] 3CL ACE2 Activation active site active sites acute kidney Acute kidney injury AKI apoptosis-related signaling pathway apoptosis-related signaling pathways binding blockade Cell Chronic kidney disease CKD clinical setting contribute Critical develop effective function functions high mortality Infection Inflammatory inhibition inhibitor Injury Interaction investigated kidney Kidney disease kidneys life cycle mechanism molecular docking network pharmacology patients with SARS-CoV-2 Potential treatment protease PROTECT protective effect Protein quercetin renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease signaling pathways specific treatment target targets therapeutic therapeutic agent transition Viral viral life cycle
[DOI] 10.1371/journal.pone.0245209 PMC 바로가기 [Article Type] Research Article

Development of Coronavirus Treatments Using Neutralizing Antibodies

Review

Published on 2021-01-132022-10-29
Journal: Microorganisms [Category] COVID-19,

Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

COVID-19에 대한 동종 세포 치료제로 사용하기 위한 회복기 기증자의 SARS-CoV-2-특정 T 세포의 신속한 GMP 준수 확장

Immunology

Published on 2021-01-082022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법,

[키워드] accumulation adoptive T cell immunotherapy Allogeneic Antigen antigens approach Blood Blood donations can be used caused CD4 CD8 cellular central memory characterized convalescent COVID-19 COVID-19 disease COVID-19 patients Culture Donor dysregulation effector T cell effector T cells expand expansion membrane memory T cell memory T cells nucleocapsid patients peptides phenotype Potential treatment Rapid reagent recognize SARS-CoV-2 spike SARS-CoV-2 virus selected T cell T cell response T cell responses T cells the SARS-CoV-2 virus therapeutic dose therapeutic doses therapy virus virus-specific T cell viruses
[DOI] 10.3389/fimmu.2020.598402 PMC 바로가기 [Article Type] Immunology