Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis염증성 사이토카인 폭풍의 심각성은 COVID-19 바이러스 SARS-CoV-2와 같은 RNA 바이러스와 소핵의 상호 작용에 의해 촉진될 수 있습니다. 가설Review Published on 2021-07-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected Aneuploidy Cell cGAS cGAS-STING. chromosomal instability COVID-19 COVID-19 virus cyclic GMP cytokine production Cytokine storm Effect elevated Evidence Factor Frequency high risk Hypothesis immune response immunologically increase individual induce Infection Inflammation Inflammatory cytokine inflammatory cytokine production Interaction interferon leakage lymphocyte mechanism Micronuclei moderate observation pro-inflammatory cytokine pro-inflammatory response reduction RNA RNA virus RNA viruses SARS-CoV-2 SASP secretory senescence Senescence Associated Secretory Phenotype severity stimulator STING susceptible threshold tissue damage virus infection viruses weakened [DOI] 10.1016/j.mrrev.2021.108395 PMC 바로가기 [Article Type] Review
Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional StudyMicrobiology Published on 2021-06-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] analyzed association Bacteria clinical disease component controls coronavirus SARS-CoV-2 correlated COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients determine Dysbiosis Evidence fungi GM-CSF Gut identify IgA response IL-17 immune response Immunoglobulin Inflammation Inflammatory cytokines Local local immune response local inflammation marker microbial community Microbiome mucosal oral Oral microbiome other diseases pandemic parameter PCR primary site pro-inflammatory cytokine progression Protective quantified Replication respiratory virus response SARS-COV-2 infection secretory IgA shown significantly subjects susceptibility symptom severity symptomatic patient systemic diseases the SARS-CoV-2 therapy TNFα to define Vaccine development virus virus infection virus replication viruses WGS [DOI] 10.3389/fmicb.2021.687513 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in MacrophagesImmunology Published on 2021-06-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor Activation Anti-inflammatory anti-inflammatory response CD14+ monocytes Cell cell type chemokines COVID-19 COVID-19 patients CXCL5 cytokine Cytokine storm Cytokines death demonstrated Engagement enzyme examined expression had no human macrophage human PBMC IL-6 IL6 IL8 inactive induce infect Inflammation inflammatory mediator Inflammatory response initiate innate immune system Interaction IRAK-M isoform LPS-activated lung Macrophage macrophages magnitude modulate mRNA mRNA expression mRNA levels PBMCs pro-inflammatory pro-inflammatory cytokine Production promoted Protein protein expression protein level receptor regulated SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 S SARS-CoV-2 S protein shown stimulated suppressed therapeutic strategy THP-1 TLR TLR ligand TNFα treated Treatment [DOI] 10.3389/fimmu.2021.683800 PMC 바로가기 [Article Type] Immunology
Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic ReviewReview Published on 2021-06-182022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] abstracts acute COVID-19 approach arise article Case report case sery characterized Clinical improvement clinical trial Complete Complication COVID-19 COVID-19 disease database Diaphragm disease Effect effective English Evidence exclusion criteria experiment Google Scholar helping Hypothesis immune response Immunity in vitro inclusion criteria Inflammation Inflammatory marker inflammatory markers intensive care unit Invasive mechanical ventilation lab low-level laser therapy lung New organ pandemic Pathogenesis Patient patients patients with COVID-19 photobiomodulation therapy Placebo positive positive result pro-inflammatory cytokine pro-inflammatory cytokines radiological reducing rehabilitation reported Research researcher review SARS-COV-2 infection severe COVID-19 severe COVID-19 patients statistically Still systematic review therapy thrombosis tissue repair Treatment Ventilation viral disease viral infection was performed Web of Science World Health Organization wound healing [DOI] 10.3390/life11060580 PMC 바로가기 [Article Type] Review
COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and MortalityImmunology Published on 2021-06-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress adaptive adipocyte adipose antigen-presenting cells Autoimmune disorders characteristic circulating contribute Coordinate Coronavirus infection COVID-19 COVID-19 patient cytokine cytokine secretion death Diseases dysregulation Fat mass function high mortality rate IL-2 IL-6 immune response Immunity Impact increase in Inflammation inflammatory condition Inflammatory cytokine Inflammatory responses Leptin long-lasting mechanism Monocytes Mortality obesity outcome pandemic progresses Patient patients with obesity plasma pleiotropic Pneumonia pro-inflammatory cytokine proliferation proportion response resulting risk factor SARS-COV-2 infection secretion severity susceptibility syndrome T helper cells Th1 the disease These cells tissue TNF-α [DOI] 10.3389/fimmu.2021.649359 PMC 바로가기 [Article Type] Immunology
Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestineResearch Article Published on 2021-06-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] absence Activation administration affected Antiviral Apoptosis coronavirus diarrhea distribution Effect ergosterol peroxide evaluate expression IFN-I immunomodulatory immunomodulatory effect in vitro study in vivo incidence Infection inhibited intestinal Intestinal barrier IκBα mechanisms modulation NF-κB p65 Porcine deltacoronavirus Prevent pro-inflammatory cytokine PROTECT protein expression reduced Replication signaling pathway small intestine tissues treat Treatment upregulating Viral load were infected [DOI] 10.1186/s13567-021-00955-5 PMC 바로가기 [Article Type] Research Article
Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patientCases with a Message Published on 2021-06-102022-10-29 Journal: Rheumatology International [Category] COVID-19, MERS, SARS, [키워드] abdomen abdominal pain Analysis analyzed caused characterized Course COVID-19 COVID-19 infection CT scan Cytokine analysis Cytokines described disease Disease progression Effect elevated female Heterotopic ossification Hospital admission Infection manifested Mild Myositis ossificans Pain Patient performed plasma sample pro-inflammatory cytokine radiological progression recovering from COVID-19 significantly Soft tissue syndrome the patient tissue area tomography warmth [DOI] 10.1007/s00296-021-04911-6 PMC 바로가기 [Article Type] Cases with a Message
A Bittersweet Response to Infection in Diabetes; Targeting Neutrophils to Modify Inflammation and Improve Host ImmunityImmunology Published on 2021-06-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] abnormality biochemical breadth chemotaxis chronic complex COVID-19 Critical diabete diabetes disease dysregulated Extracellular Future handling highlighting Host host immunity hyperglycaemia immune response IMPROVE increased risk individual Infection Inflammation innate immune system mechanism morbidity and mortality NET NETosis neutrophil neutrophil dysfunction Neutrophil extracellular trap neutrophil function neutrophil recruitment occur pathogen Pathways Patient phagocyte phagocytosis phenotype pro-inflammatory pro-inflammatory cytokine proinflammatory reactive oxygen specy recurrent infection Research response ROS severe coronavirus disease significantly T1D T2D targeting therapy Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated [DOI] 10.3389/fimmu.2021.678771 PMC 바로가기 [Article Type] Immunology
Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapyArticle Published on 2021-06-012022-10-04 Journal: Drug development research [Category] 신약개발, [키워드] 3CL alleviate Anti-inflammatory antiviral drug Celecoxib chemokines Coagulopathy Contagion coronavirus Coronavirus infection COVID-19 COVID-19 infection COVID-19 pandemic COX-2 cytokine Diclofenac drug effective Effectiveness enzyme H1N1 H5N1 Health highlight HIV immunogenic immunomodulatory imunomodulation. indomethacin Infection Inflammasome Inflammatory response inhibiting involved malarial MERS-CoV metabolites modulate morbidity NSAID NSAIDS overexpressed overexpression pandemic pathway Pathways pro-inflammatory pro-inflammatory cytokine protease provided robust SARS-CoV-1 severity substrate Support symptomatic synergistic targeting therapeutic therapeutic regime therapy tissue Treatment urgency viral infection viral replication viral spike proteins worsening ZIKV [DOI] 10.1002/ddr.21794 PMC 바로가기 [Article Type] Article
Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A reviewReview article Published on 2021-06-012022-10-05 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Clinical significance coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine cytokine level Cytokines develop disease Disease progression Diseases disorder ENhance global pandemic group Host IL-6 immune immunoassay immunoassays immunological disorder implementation implicated individual Inflammatory biomarker inflammatory biomarkers Inflammatory response Inflammatory responses inflammatory status Interpretation Kawasaki disease knowledge Laboratory management multiplex Multiplex cytokine analysis nucleic acid amplification observation pediatric Pediatric patient platform pro-inflammatory cytokine Prognosis risk SARS-CoV-2 serum cytokine level Serum level severe COVID-19 the SARS-CoV-2 therapy Treatment utility variable with COVID-19 [DOI] 10.1016/j.cyto.2021.155478 [Article Type] Review article