RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced [DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology
Recognition of phrenic paralysis as atypical presentation during CT chest examination of COVID-19 infection and its correlation with CT severity scoring: a local experience during pandemic eraResearch Published on 2021-06-232022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] Anosmia association Atypical cells change changes Chest clinical manifestation complete recovery complication of COVID-19 complications consolidations Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 infection COVID-19 pneumonia CT chest CT severity score Cytokine storm diaphragmatic digestive disease Endothelial dysfunction Evidence explain Follow-up global pandemic ground glass IL-6 incidence include interleukin-6 Local lung majority neurological Neurological complication pandemic era paralysis Patient phrenic Phrenic nerve paralysis Pneumonia Recognition Result resulting RT-PCR septal thickening severity shown Symptom World Health Organization [DOI] 10.1186/s43055-021-00527-9 PMC 바로가기 [Article Type] Research
Antiphospholipid Antibodies and Infection: Non Nova Sed Nove항인지질 항체 및 감염: Non Nova Sed NoveObservational Study Published on 2021-06-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] antibody antiphospholipid antibodies antiphospholipid antibody syndrome caution Clinical significance Clinical studies clinical study Coagulopathy contest COVID COVID-19 COVID-19 patients described detectable diagnosed effective generalization hospitalized patient hospitalized patients Infection infections Interpretation investigated management mechanism Nova Patient patients with COVID-19 performed positive pro-thrombotic Recognition required syndrome syphilis the patient thrombosis thrombotic while with COVID-19 with infections Wuhan Wuhan, China [DOI] 10.3389/fimmu.2021.687534 PMC 바로가기 [Article Type] Observational Study
A comprehensive review on global contributions and recognition of pharmacy professionals amidst COVID-19 pandemic: moving from present to futureReview Published on 2021-06-112022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] Abstract activities activity Analysis article Care caused clinical Clinical data collaboration Collaborative effort Combination Community COVID-19 COVID-19 infected patient COVID-19 outbreak COVID-19 pandemic COVID-19 situation database Direct events Google Scholar healthcare Healthcare professional healthcare service hospital Industrial infection control information limitation medication pandemic Pharmacist professional question Recognition respiratory tract infection responsible retrieved SARS-CoV-2 Science Support suppress the disease the SARS-CoV-2 virus [DOI] 10.1186/s43094-021-00273-9 PMC 바로가기 [Article Type] Review
How Children Are Protected From COVID-19? A Historical, Clinical, and Pathophysiological Approach to Address COVID-19 SusceptibilityCOVID-19로부터 어린이를 보호하는 방법은 무엇입니까? COVID-19 감수성을 해결하기 위한 역사적, 임상적, 병태생리학적 접근Immunology Published on 2021-06-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accompanied ACE-2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity address affected autoimmune disorder B1 B cells Bacteria Bacterial bacterial pathogen Bacterial pathogens Behcet’s disease children China class clinical coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Defense disease exhibiting favor genetics IgM Immunity Immunoglobulin innate immune Iran Italy Kawasaki-like disease mechanism membrane membranes molecular mechanisms Mortality Native natural IgM Neonate Neonates neutralize oxygen Pathogens Patient Pediatric patient Pediatric patients Prevalence progression reactive oxygen species reactive oxygen specy Recognition Region respiratory SARS-CoV-2 selective self-antigens severe acute respiratory syndrome Coronavirus severe COVID-19 silk road South Spread stressed cells Symptom the epidemic thrombosis Trigger Turkey Vasculitis Viral viral envelope virus [DOI] 10.3389/fimmu.2021.646894 PMC 바로가기 [Article Type] Immunology
High rates of antibiotic prescriptions in children with COVID-19 or multisystem inflammatory syndrome: A multinational experience in 990 cases from Latin AmericaCOVID-19 또는 다기관 염증 증후군 아동의 높은 항생제 처방률: 라틴 아메리카에서 990건의 다국적 경험Article Published on 2021-06-012022-09-11 Journal: Acta paediatrica (Oslo, Norway : 1992) [Category] SARS, 치료기술, [키워드] administration antibiotic antibiotic use Antibiotics ARDS Bacterial infection Bacterial infections Care chest X-ray chest X-rays children children with COVID-19 Corticosteroids country COVID-19 CPAP determinant diagnosis of COVID-19 enrolled Evidence Factor female FIVE hospital hospital care hospitals Inflammatory intensive care Latin America management mechanical ventilation MIS-C oxygen oxygen support Pneumonia Prevalence Prospective Pyrexia Recognition SARS-CoV-2 severe disease Sex stewardship. systemic corticosteroid systemic corticosteroids use of antibiotics Variation were assessed with COVID-19 [DOI] 10.1111/apa.15847 PMC 바로가기 [Article Type] Article
Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic유형 III CRISPR-Cas 시스템에 의한 고유 신호 증폭은 서열 특이적 SARS-CoV-2 진단을 제공합니다Report Published on 2021-05-272022-09-10 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] Abstract activate Activation amplification amplified product ATP clinically complementary complex conserved conserved regions COVID-19 CRISPR CRISPR Dx CRISPR-Ca CRISPR-Cas decrease detect detectable diagnostic domain followed by generate guide RNA IMPROVE less limit of detection Multiplexing oligonucleotides Patient point-of-care diagnostics polymerase proton protons provide Recognition Region RNA RT-LAMP SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 RNA sensitivity Trigger triggers type III viral diagnostics viruses [DOI] 10.1016/j.xcrm.2021.100319 PMC 바로가기 [Article Type] Report
Mechanism of Ligand Recognition by Human ACE2 Receptor인간 ACE2 수용체에 의한 리간드 인식 메커니즘Article Published on 2021-05-272022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 신약개발, 치료제, [키워드] accelerated ACE2 ACE2 receptor active site acute respiratory syndrome addressed Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding conformational conformations coronavirus coronaviruses SARS-CoV Critical diabetes Diseases drug design drug target enzyme epithelial cell epithelial cells expected experimental structure expressed facilitate flexible heart heart failure homeostasis Human human ACE2 human ACE2 receptor human diseases hypertension inhibitor kidney Ligand Lungs mechanism MLN-4760 molecular molecular dynamics pancreas pulmonary diseases receptor Recognition Regulation renal Renin renin-angiotensin system SARS-CoV-2 Severe acute respiratory syndrome X-ray [DOI] 10.1021/acs.jpclett.1c01064 PMC 바로가기 [Article Type] Article
Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질에 의해 인식이 변경된 인간 ACE2 변이체의 발견Research Article Published on 2021-05-122022-09-10 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 ACE2 residue ACE2 residues ACE2 sequence Analysis axis Clinical trial design complementary COVID-19 epidemiological facilitate Genetic variant human ACE2 identify Interaction mutant Recognition Research SARS-CoV-2 single-nucleotide SNVs Spike protein strain the SARS-CoV-2 understanding utility variant virus [DOI] 10.1371/journal.pone.0251585 PMC 바로가기 [Article Type] Research Article
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection교차 중화 항체의 조합은 SARS-CoV-2 및 SARS-CoV 슈도바이러스 감염을 예방하기 위해 상승합니다.Article Published on 2021-05-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] 3D structure Abstract antibodies antibody antibody cocktail antibody-antigen interaction antigenic antigenic drift antigenic variation B.1.1.7 B.1.351 bind bound waters caused circulating variant circulating variants Combination complex conserved coronavirus coronavirus disease Coronavirus disease 2019 COVA1-16 COVID-19 COVID-19 patient CR3022 cross-neutralizing cross-neutralizing antibodies cross-neutralizing antibody cross-react cross-reactivity crystal structure crystal structures Crystallography Effectiveness ENhance Epidemics facilitate glycan glycosylation site Infection information interact Interaction neutralization neutralize Neutralizing antibodies Pandemics Prevent PROTECT provide receptor-binding domains Recognition related viruses S309 Sarbecoviruses SARS-CoV SARS-CoV pseudovirus SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronaviruses SARS-related virus SARS-related viruses shown spike spikes Structure synergy the receptor-binding domain therapeutic therapeutic antibodies these viruses threat Threats Vaccine viruses X-ray zoonotic [DOI] 10.1016/j.chom.2021.04.005 PMC 바로가기 [Article Type] Article