COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protectionArticle Published on 2022-10-152022-11-15 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] adverse effects analyzed biological basis booster clinical impact COVID-19 COVID-19 vaccine COVID-19 vaccines death effective Effectiveness immune correlate Immunity knowledge pandemic potential mechanism provided public health reduced regimen researcher risk SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants severe adverse events the SARS-CoV-2 virus Vaccine Vaccines variant virus with COVID-19 [DOI] 10.1186/s12929-022-00853-8 PMC 바로가기
Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and WalesArticle Published on 2022-10-152022-11-16 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted age analyses Analysis aRR association B.1.1.529 benefit BNT162b2 booster booster dose Booster vaccine calculated ChAdOx1 nCoV-19 Chronic kidney disease Committee Comorbidities Comorbidity conducted core covariates COVID-19 COVID-19 hospitalisation COVID-19 infection COVID-19 therapeutics COVID-19 vaccination current death dominant Edinburgh England event group Health health condition high risk hospitalisation identify immunisation Immunosuppressant increased risk individual initial Innovation Ireland male Medical Research Council meta-analyses Moderna mortality data mRNA-1273 Multimorbidity National of BNT162b2 offer older adult outcome outcomes Oxford-AstraZeneca per 1000 person-year per 1000 person-years Pfizer-BioNTech Poisson regression model primary care prospective cohort prospective cohort study rate ratio receiving reduced reduced risk remained risk risk factor RT-PCR testing SARS-COV-2 infection Scottish severe COVID-19 Sex those with comorbidity university vaccination Vaccine vaccine dose vaccine group variant [DOI] 10.1016/S0140-6736(22)01656-7 PMC 바로가기
Do COVID-19 CT features vary between patients from within and outside mainland China? Findings from a meta-analysisArticle Published on 2022-10-142022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Chest Chest computerized tomography Chest CT China clinician Cochrane Library consolidation coronavirus disease COVID-19 database Diagnosis diagnostic diagnostic value evaluate feature finding GGO ground-glass opacity incidence incidence rate lung involvement Meta-analysis nodule Patient performed Pneumonia Quality R software radiologist regions retrieved risk SARS-CoV-2 screened septal thickening significantly higher significantly lower the patient two group Vascular was used [DOI] 10.3389/fpubh.2022.939095 PMC 바로가기
The safety of esophageal cancer surgery during COVID-19Article Published on 2022-10-142022-11-16 Journal: Medicine [Category] meta-analysis, [키워드] 95% confidence interval anastomotic Blood Cancer Chinese Cochrane Library complications conducted coronavirus disease COVID-19 COVID-19 pandemic database determine evaluate Evidence Fang heterogeneity Hospital stay ICU identify Infrastructure intensive care journal mean difference Meta-analysis Mortality outcome outcomes pandemic Patient postoperative Primary outcome random effect model readmission Registered researchers risk risk ratio secondary outcome surgical systematic review Trial was performed Web of Science were used [DOI] 10.1097/MD.0000000000030929 PMC 바로가기
The impact of vaccine hesitation on the intentions to get COVID-19 vaccines: The use of the health belief model and the theory of planned behavior modelArticle Published on 2022-10-142022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Affect affecting conducted covariate COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical cross-sectional Factor Factors group HBM HBM (health belief model) Health Healthcare provider help Intention Intervention MOST Multiple linear regression perceived benefit proportion receive recruited risk Self-efficacy Standard deviation survey platform T-tests the vaccine TPB (theory of planned behavior) vaccinated against COVID-19 vaccination vaccination intention vaccination intentions Vaccine vaccine hesitation. variant were expressed were used [DOI] 10.3389/fpubh.2022.882909 PMC 바로가기
Hospitalisation and mortality risk of SARS-COV-2 variant omicron sub-lineage BA.2 compared to BA.1 in EnglandArticle Published on 2022-10-132022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI confounders country COVID-19 case death dominant variant England hazard hospital Hospital admission hospitalisation Infection investigated large cohort mortality risk multivariable omicron outcome public health regression models risk SARS-CoV-2 stratified variant variant of SARS-CoV-2 [DOI] 10.1038/s41467-022-33740-9 PMC 바로가기
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19Article Published on 2022-10-132022-11-15 Journal: International Journal of Epidemiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 95% CI adjusted odds ratio Admission age antiviral response association co-morbidity conducted COVID-19 COVID-19 diagnosis Critical care death develop diagnosed with COVID-19 enrolment Epidemiology European Factor Factors General population genetic data genetic risk factor Genetic variant greater highest hospital Hospitalization identify IMPROVE individual interquartile range lowest median men morbidity obesity outcomes participant Pathway analysis Pathways Patient polygenic risk score polymorphism PRS reported risk risk factor risk prediction severe COVID-19 single-nucleotide Smokers socio-demographic UK biobank was performed [DOI] 10.1093/ije/dyac137 PMC 바로가기
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5Article Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 binding alveolar epithelial cell BA.2 BA.2.12.1 BA.4 BA.5 bind Characteristics COVID-19 Culture effective experiment greater hamster Health human ACE2 immune immune evasion immune resistance Immunity Infection less omicron pathogenic pathogenicity provided replicate Reproduction number risk SARS-CoV-2 spike receptor-binding domain Spread statistical analysis Substitution suggested the SARS-CoV-2 Transmissibility [DOI] 10.1016/j.cell.2022.09.018 PMC 바로가기