Oil immersed lossless total analysis system for integrated RNA extraction and detection of SARS-CoV-2SARS-CoV-2의 통합 RNA 추출 및 검출을 위한 오일 침지 무손실 종합 분석 시스템Article Published on 2021-07-142022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] Analysis biomedical engineering bottlenecks clinical samples costly COVID-19 COVID-19 pandemic diagnostic diagnostics effective faster followed by highlighting include Infectious disease Infectious-disease diagnostics Infrastructure Lab-on-a-chip methodology Nasopharyngeal swab nucleic acid nucleic acid extraction Oil positive Predictive qPCR qPCR assay qPCR assays quantitative PCR RNA extraction SARS-CoV-2 SARS-CoV-2 viral Supply chain System Total Viral [DOI] 10.1038/s41467-021-24463-4 PMC 바로가기 [Article Type] Article
Clinical efficacy of Nafamostat Mesylate in combination with Favipiravir for COVID-19 pneumonia treatment review articleReview Published on 2021-07-142022-10-04 Journal: Annals of Medicine and Surgery [Category] 신약개발, 임상, 치료법, 치료제, [키워드] alleviation Anti-inflammatory Antibiotics Anticoagulants Antidote antivirals approach assigned Care category clinical clinical information Clinical outcome collected Combination Compound concerning condition conditions conducted coronavirus COVID COVID-19 COVID-19 infected patient COVID-19 infected patients COVID-19 patient detrimental development drug drugs Effect effective Efficacy enzyme explicit Favipiravir health condition hospital immune implication infected individuals infected patients information inhibit Inpatient intensity involved Laboratory literature review mesylate nafamostat Nafamostat mesylate novel Occurrence outcomes pathologist Patient patients Perspective Pneumonia Prevalence Probability reduce reduction Research research finding researcher responsible RNA polymerase SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-CoV-2 viral Severe respiratory distress therapy Treatment utilised Vaccine viral epidemics viral strain virus strain [DOI] 10.1016/j.amsu.2021.102560 PMC 바로가기 [Article Type] Review
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies급성 SARS-COV-2 감염의 바이러스 역학 및 진단 및 공중 보건 전략에 대한 적용Research Article Published on 2021-07-122022-09-10 Journal: PLoS Biology [Category] SARS, 진단, 치료기술, [키워드] 95% CI acute infections acute SARS-CoV-2 infection asymptomatic individual Asymptomatic individuals average certainty characterized clearance clinical care Concentration credible interval Cycle threshold value Decline diagnostic early stage early stages effective sensitivity followed by help identify IMPROVE individual Infection infectious initial Intervention mathematical mathematical model measure PCR testing peaked positive PCR test public health Quantitative remained reverse transcription PCR SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral stages Surveillance symptomatic individual symptomatic individuals Symptoms test turnaround time trajectory Viral viral clearance viral dynamics viral proliferation Viral RNA Viral RNA shedding [DOI] 10.1371/journal.pbio.3001333 PMC 바로가기 [Article Type] Research Article
Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded TissuesProtocol Published on 2021-07-102022-10-30 Journal: Methods and Protocols [Category] COVID-19, [키워드] Autopsy biologic caused Cell cell tropism clearance rate common conserved contagious Control coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID-19 patient Deceased detect died disease distribution expected experimental animal model Human human tissue Immunoglobulin immunohistochemistry immunohistochemistry protocols include Infection Level life-threatening lung lung tissue negative Non-COVID-19 nucleocapsid nucleocapsid protein paraffin paraffin-embedded Patient patients polyclonal antibody Protein protocol qRT-PCR Quantitative raised recognize reservoirs Respiratory disease RNA SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 viral sensitive sequence Specific Spike protein stages strain Support tissue variants of SARS-CoV-2 Viral antigen viral strains virus virus-infected cell [DOI] 10.3390/mps4030047 PMC 바로가기 [Article Type] Protocol
Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)중증 급성 호흡기 증후군-코로나 바이러스 2 (SARS-COV-2)에 대한 "필수 요오드 방울"의 효능Research Article Published on 2021-07-092022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료제, [키워드] 1:1 aerosolization aqueous solution ATCC CCID Cell Cell culture complex controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CPE Cytopathic effect demonstrated Dilution drop effective end-point dilution Essential evaluated fulvic acid in vitro infecting infectious dose intranasal intranasally Iodine pandemic povidone-iodine Prevent quantified reduce reduced reducing reductions in respiratory respiratory droplet Respiratory droplets Result room temperature SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome Spread temperature titre titres Vero Viral Viral load virucidal virus virus stock viruses was reduced was tested [DOI] 10.1371/journal.pone.0254341 PMC 바로가기 [Article Type] Research Article
Efficacy and Safety of Leflunomide for Refractory COVID-19: A Pilot StudyPharmacology Published on 2021-07-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome age assigned clearance rate coronavirus coronavirus disease Course COVID-19 death discharge rate enrolled hospital discharge rate Hospitalized IMPROVE IQR large sample leflunomide observation Patient patients pilot study Pneumonia positive Primary outcome Randomized controlled trial receive receiving refractory reported Safety SARS-CoV-2 SARS-CoV-2 clearance SARS-CoV-2 viral severe adverse event standard care Standard of care the median the SARS-CoV-2 Tolerability Treatment [DOI] 10.3389/fphar.2021.581833 PMC 바로가기 [Article Type] Pharmacology
Tracking COVID-19 with wastewater to understand asymptomatic transmission무증상 전파를 이해하기 위해 폐수로 COVID-19를 추적Article Published on 2021-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Asymptomatic asymptomatic transmission can be used Chain Reaction collected complementary copy number COVID-19 dataset develop feces followed by help increase in Most patients no significant difference no significant differences outbreak Pandemics patients PCR polymerase chain polymerase chain reaction provided random real-time polymerase chain reaction reported RNA copy numbers SARS-CoV-2 SARS-CoV-2 in wastewater SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 viral RNA Surveillance Transmission Viral load Viral RNA wastewater Wastewater of Bangkok. Waves were measured [DOI] 10.1016/j.ijid.2021.05.005 PMC 바로가기 [Article Type] Article
Pharmacokinetics and pharmacodynamics of hydroxychloroquine in hospitalized patients with COVID-19COVID-19 입원 환자에서 하이드록시클로로퀸의 약동학 및 약력학Observational Study Published on 2021-07-012022-09-11 Journal: Thérapie [Category] SARS, 임상, 치료기술, [키워드] 95% confidence interval Administered Analysis Bioavailability C-reactive protein circulating clearance Concentration covariates COVID-19 COVID-19 patient COVID-19 patients daily dose distribution dosage dose e parameters effective elimination half-life estimate followed by half-life HCQ hospitalized patient hospitalized patients Hydroxychloroquine in vitro Inflammation inhibit intensive care units Liquid chromatography Loading doses Lupus median nasopharyngeal swabs Non-COVID-19 patients parameter Patient performed Pharmacodynamics pharmacokinetic pharmacokinetic analysis pharmacokinetic data pharmacokinetics plasma plasma concentration ranged reported required reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 patient severe COVID-19 patients tested Variability viral clearance Volume volume of distribution were measured with COVID-19 [DOI] 10.1016/j.therap.2021.01.056 PMC 바로가기 [Article Type] Observational Study
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral InfectionSARS-CoV-2 바이러스 감염 중 자가항원 발현 향상Immunology Published on 2021-06-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation Analysis Asymptomatic COVID-19 autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity Autopsy bioinformatics Blood conducted confirmed case confirmed cases COVID-19 COVID-19 infections datasets determine Effect enhanced evaluate expression level expression levels follow-up studies follow-up study homeostasis IFIH1 Immune homeostasis immunopathology in-silico Infection infections lead longitudinal low-density lung lung autopsies mononuclear cell mononuclear cells MPO neutrophil neutrophil activation overexpressed PADI4 PBMCs Peripheral blood Peripheral blood mononuclear cells plasma protein protein level protein levels PRTN3 PTPRN2 respiratory viral infection SAR-CoV-2 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 infections severity of COVID-19 significantly single-cell dataset subset tissue Tolerance transcriptomic TRIM21 TSHR upregulated upregulation Viral viral infection viral infections Whole blood [DOI] 10.3389/fimmu.2021.686462 PMC 바로가기 [Article Type] Immunology
Effect of Tenofovir Disoproxil Fumarate and Emtricitabine on nasopharyngeal SARS-CoV-2 viral load burden amongst outpatients with COVID-19: A pilot, randomized, open-label phase 2 trialResearch Paper Published on 2021-06-272022-10-04 Journal: EClinicalMedicine [Category] 신약개발, 임상, [키워드] 1:1 95% CI 95% confidence interval accelerate Adverse adverse events assigned baseline clearance Cohort collected conducted COVID-19 COVID-related symptoms cycle threshold develop died drug discontinuation early treatment Effect emtricitabine Endpoint enrolled enrolment event finding France fumarate funding gastrointestinal side effect hospital hospitalisation in both groups Inclusion increase in Infection interfere IQR less median nasopharyngeal Nasopharyngeal swab Open-label Other Outpatient Patient per day phase 2 trial pilot study Randomized Randomly RdRP receive Registered reported RNA polymerase RT-PCR SARS CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2 viral load secondary endpoint severe COVID-19 Standard of care Support symptom onset tenofovir therapy Time to recovery treated treatment group Trial viral burden [DOI] 10.1016/j.eclinm.2021.100993 PMC 바로가기 [Article Type] Research Paper