Severity of disease – Page 14 – Communicable Diseases Research

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

SARS-CoV-2 폐 감염에 대한 숙주 반응의 시간적 및 공간적 이질성

Article

Published on 2020-12-092022-09-10
Journal: Nature Communications [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 진단,

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Randomized Controlled Trial

Published on 2020-12-082022-10-05
Journal: JAMA [Category] 임상,

[키워드] absolute difference acute respiratory syndrome adult outpatient adverse events age assigned clinical Clinical deterioration Clinical efficacy clinical trial coronavirus Coronavirus disease 2019 COVID-19 criteria cytokine production decrease defined Deterioration determine enrolled excessive immune response Final fluvoxamine Follow-up greater Hospitalization Infection less likelihood mild COVID-19 illness occurred outcome outcome measures Outpatient oxygen saturation participant Patient patients treated Placebo Pneumonia Prevent Primary outcome randomization Randomized randomized trial Randomly receive receptor regulate Serious Adverse Event Severity of disease Shortness of breath small sample size supplemental oxygen survival symptom onset symptomatic the placebo group Trial with COVID-19 women
[DOI] 10.1001/jama.2020.22760 PMC 바로가기 [Article Type] Randomized Controlled Trial

Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19

Original Article

Published on 2020-12-072022-11-01
Journal: Genomics & Informatics [Category] COVID-19,

[키워드] acute respiratory syndrome affected aligned caused coronavirus coronavirus disease COVID-19 COVID-19 patient D614G database detective disease severity downloaded Frequency Genome genome sequence genomic sequence GISAID groups help initiative mutant Mutation mutations non-coding region P323L P323L mutation Patient pneumonia virus profile Protein RdRP reference sequence required resulting RNA-dependent RNA polymerase SARS-CoV-2 sequence severity severity of COVID-19 Severity of disease silent spike Spike protein spike protein D614G statistically significant the SARS-CoV-2 typing variant Wuhan
[DOI] 10.5808/GI.2020.18.4.e44 PMC 바로가기 [Article Type] Original Article

Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis

Review

Published on 2020-12-022022-10-31
Journal: European Journal of Medical Research [Category] COVID-19, MERS, SARS,

[키워드] 95% CI Analysis association BMI body mass index calculate carried conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical data extraction database demonstrated Disease progression effort greater hospital ICU care information Invasive mechanical ventilation Meta-analysis mild COVID-19 patient Mortality obese obesity Odds ratio outcome patients patients with COVID-19 Pneumonia poor outcomes progression random-effects model reported Research Result risk risk factor severe COVID-19 severity of COVID-19 Severity of disease systematic review the disease was performed Web of Science younger patient
[DOI] 10.1186/s40001-020-00464-9 PMC 바로가기 [Article Type] Review

C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19

코로나19로 입원한 환자의 예후 지표로서의 C 반응성 단백질

Research Article

Published on 2020-11-202022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] Admission Analysis association conducted COVID CRP CRP level CRP levels CRP value CRP values declines died Disease progression elevated entire cohort facilitate Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient ICU ICU admission in-hospital mortality IQR linear median medical record medical records Patient patients patients with COVID-19 peaked prognostic indicator progression Protein recent reported retrospective cohort risk stratification Seven Severity of disease significantly higher Support System the median the patient those who survived threshold utility with COVID-19
[DOI] 10.1371/journal.pone.0242400 PMC 바로가기 [Article Type] Research Article

Metagenomic Next-Generation Sequencing of Nasopharyngeal Specimens Collected from Confirmed and Suspect COVID-19 Patients

COVID-19 확인 및 의심 환자로부터 수집된 비인두 표본의 메타게놈 차세대 시퀀싱

Research Article

Published on 2020-11-202022-09-10
Journal: mBio [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis analyzed applied approach Bacterial bioinformatics cause characterized Confirmed coronavirus Corynebacterium CoV COVID-19 Critical cycle threshold decrease detect diagnosing disease Disease progression disease severity Diversity early stage early stages evaluate Evidence global public health Health crisis infecting pathogens information invasive Metagenomic next-generation sequencing metagenomic sequencing metagenomics metatranscriptomic microbial Microbial communities microbial community Microbiome nasopharyngeal Next-generation sequencing NP swab NP swabs offer organism Oxford pathogen detection Pathogens Patient patients platform positive Prognosis progression provide public health reduction in respiratory RT-PCR sampling SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 RNA detection SARS-CoV-2 sequence SARS-CoV-2 sequences sequenced severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Severity of disease specimen specimens statistically significant swab specimen swabs symptom onset utility Viral Viral RNA
[DOI] 10.1128/mBio.01969-20 PMC 바로가기 [Article Type] Research Article

Glasgow Early Treatment Arm Favirpiravir (GETAFIX) for adults with early stage COVID-19: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-11-192022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] 1:1 48 hours able to swallow accompany addition age Alexandra Algorithm ALT Antiviral Arm AST authority baseline Blinding Breastfeeding childbearing clinical clinically clinician co-morbidities co-morbidity Concomitant medication contribute control arm COVID COVID-19 COVID-19 infection COVID-19 test death defined dialysis disease dissemination doses drug duration of symptom early early stage effective Efficacy eight element Elizabeth EudraCT European excluded experimental arm Factor Favipiravir female females first positive greater haemofiltration Health hereditary xanthinuria history hospital hospitalisation hypersensitivity hypertension Hypothesis impairment in-patient Infection Infirmary information Inpatient ISARIC4C ISRCTN Loading dose maintenance dose male measure mechanism medication men metabolite negative number obesity objective offered open label Other outcome Outpatient Oxygen therapy parallel group participant Patient patients patients with COVID-19 pharmacokinetic pharmacokinetics Point positive pregnancy test pregnant Primary outcome principal investigator protocol random randomisation randomised randomised controlled trial Randomised trial receive recruit recruited recruitment reducing reference Registered Regulating reported risk risk of death Safety Sample size SARS-CoV-2 sequence severe hepatic impairment severity Severity of disease Sex Standard Standard of care standard treatment standard treatment alone status Study protocol Symptom the primary endpoint the WHO Tolerability Total treated Treatment treatment allocation treatment for COVID-19 Trial ULN undergo union university website WHO with COVID-19 women
[DOI] 10.1186/s13063-020-04891-1 PMC 바로가기 [Article Type] Letter

Structured ICU resource management in a pandemic is associated with favorable outcome in critically ill COVID‑19 patients

Main Topic

Published on 2020-11-102022-10-29
Journal: Wiener Klinische Wochenschrift [Category] COVID-19, SARS,

[키워드] Acute kidney injury acute respiratory syndrome adaptive age cohort study Comorbidity complex coronavirus COVID-19 Critically ill Critically ill patient Date extracorporeal membrane oxygenation Final first symptom Follow-up hospital Hospital stay ICU ICU admission intensive care interquartile range Invasive mechanical ventilation IQR LOS majority male management measure mechanical ventilation median Mortality no significant difference outcome Patient patients positive Rapid receiving required resource resources Result SARS-CoV-2 SARS-CoV‑2 Severity of disease state still hospitalized supplementary material tested therapy Treatment were recorded with COVID-19
[DOI] 10.1007/s00508-020-01764-0 PMC 바로가기 [Article Type] Main Topic

Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset

질병 발병 후 최대 6개월까지 COVID-19 환자 및 건강한 지원자에서 항-SARS-CoV-2 항체의 혈청유병률

Clinical Trial

Published on 2020-11-102022-08-13
Journal: European Journal of Immunology [Category] MERS, SARS, 임상, 진단, 치료기술,

[키워드] age Anti‐SARS‐CoV‐2 antibody response Anti‐SARS‐CoV‐2 antibody responses anti‐SARS‐CoV‐2 IgG antibody antibody antibody production Antibody Response Antibody titer Asymptomatic circulating classic Clinical signs COVID‐19 COVID‐19 patient COVID‐19 described detect detectable disease onset Fever healthcare Healthcare workers healthy volunteer highlight hospital human pathogen humoral immune response IgA antibodies IgA antibody IgG IgG antibodies IgM immune response immunological information initial longitudinal analysis men Mild MONITOR neutralising antibody neutralization activity Neutralizing antibodies Patient peaking proportion protective immunity Protein provide quantified rapid increase RBD receptor‐binding domain recognizing reduce remained robust SARS‐CoV‐2 SARS‐CoV‐2 screened Seroprevalence setup Severity of disease Spread subject subjects Symptoms tested the Spike titre titres university virus volunteers were infected
[DOI] 10.1002/eji.202048970 PMC 바로가기 [Article Type] Clinical Trial

Dermatological findings in SARS-CoV-2 positive patients: An observational study from North India

SARS-CoV-2 양성 환자의 피부과 소견: 북인도의 관찰 연구

Observational Study

Published on 2020-11-012022-09-11
Journal: Dermatologic therapy [Category] SARS, 임상, 치료기술,

[키워드] acute respiratory syndrome affected age clinical examination Clinical severity coronavirus coronavirus disease COVID-19 COVID-19 patients cutaneous manifestation Dermatology determine eight ethical committee extremities followed by Frequency group India itching lesion maculopapular rash males manifestation Manifestations mucosal North Novel coronavirus Patient patients population groups positive Rash reported respiratory resulting SARS-CoV-2 SARS-CoV-2 positive patient SARS-CoV-2 positive patients Severe acute respiratory syndrome Severity of disease Signs and symptoms skin Symptom Symptoms trunk was done
[DOI] 10.1111/dth.13849 PMC 바로가기 [Article Type] Observational Study