Systems on Top of Nasal Cannula Improve Oxygen Delivery in Patients with COVID-19: a Randomized Controlled TrialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Journal of General Internal Medicine [Category] 임상, [키워드] addition arterial blood baseline breathlessness cannula changes in collected Controlled Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 pandemic COVID-19 patients delivery determine double-trunk mask Efficacy enrolled Final Hypoxemia hypoxemic IMPROVE low-flow oxygen median nasal outcome oxygen oxygen saturation Oxygen therapy Oxygenation PaO Primary outcome pulse Randomized randomized patients receive reduce secondary surgical surgical mask System treated treating vital parameter vital parameters was recorded was reduced with COVID-19 [DOI] 10.1007/s11606-022-07419-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Automated System for Identifying COVID-19 Infections in Computed Tomography Images Using Deep Learning ModelsArticle Published on 2022-03-302022-11-16 Journal: Journal of Healthcare Engineering [Category] 치료기술, [키워드] Accuracy Affect assist Clinical symptoms CNN Combination complications Contact Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 virus criteria dataset deep deep learning determine develop diagnose diagnostic disease domain early stages epidemiological Fatality rate Final healthcare highest identifying Image Incubation period Laboratory test learning Model Modification nucleic acid amplification outcome Patient sensitivity specificity System this system tomography was used [DOI] 10.1155/2022/5329014 PMC 바로가기
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases호중구 대 림프구 비율: 면역 체계와 질병 간의 관계에 대한 새로운 지표Review Published on 2022-03-262022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, [키워드] adaptive Adaptive immunity Biomarker Cancer concerning coronavirus coronavirus disease coronavirus disease-2019 coronavirus disease-2019 (COVID-19) COVID-19 COVID-19 pneumonia cut-off value disease FLAG General population homeostasis immune system Immunity inflammatory status intensive care intensive care unit intensive care unit (ICU) lymphocyte marker molecular basis Mortality neutrophil Neutrophil-to-lymphocyte ratio neutrophil-to-lymphocyte ratio (NLR) NLR over pathophysiology patients with COVID-19 Pneumonia Prognosis Prognostic value relationship Research Sepsis subset System unique [DOI] 10.3390/ijms23073636 PMC 바로가기 [Article Type] Review
Repurposing Multiple-Molecule Drugs for COVID-19-Associated Acute Respiratory Distress Syndrome and Non-Viral Acute Respiratory Distress Syndrome via a Systems Biology Approach and a DNN-DTI Model Based on Five Drug Design Specifications5가지 약물 설계 사양을 기반으로 하는 시스템 생물학 접근법 및 DNN-DTI 모델을 통한 COVID-19 관련 급성 호흡곤란 증후군 및 비바이러스성 급성 호흡곤란 증후군에 대한 다분자 약물 용도 변경Article Published on 2022-03-262022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome advance AIC Akaike information criterion approach ARDS Biology Biomarker Biomarkers candidate drug candidate drugs clinical manifestation clinical manifestations convenience coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-associated ARDS criterion database deep neural network drug drug candidate drug design drug target drug-likeness drug-target DTI model Epidemic Epigenetic etiologic mechanism excretion False positive False positives Genetic help host-pathogen RNA-Seq data HPI-GWGEN information Interaction KEGG mechanism Mitigation Model morbidity morbidity and mortality non-viral ARDS Pathogenesis pathogenic pathophysiology pathway Pathways PNP predict predicted Regulation repurposing respiratory respiratory distress RNA sequencing SARS-CoV-2 sensitivity signaling pathway specification syndrome System Systems biology therapeutic option Therapeutic treatment Toxicity [DOI] 10.3390/ijms23073649 PMC 바로가기 [Article Type] Article
Low-Cost, Real-Time Polymerase Chain Reaction System for Point-of-Care Medical Diagnosis현장 진료 의료 진단을 위한 저비용, 실시간 중합효소 연쇄반응 시스템Article Published on 2022-03-172022-09-11 Journal: Sensors (Basel, Switzerland) [Category] 치료제, [키워드] addition alternative Analysis approach Bill of materials can be used Care chain Chain Reaction circumvent clinics comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 described diagnostic disease DNA amplification environmental monitoring faster Fluorescence fluorescence detection fluorescence sensing food food quality gel electrophoresis Health Health care help hospital initial low-cost PCR Measures medical diagnostics optical pandemic PCR performed PID point-of-care point-of-care diagnostics polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) proportional–integral–derivative (PID) controller reaction reagents Real-time PCR real-time PCR system reducing selective sensitivity speed System tested water water quality [DOI] 10.3390/s22062320 PMC 바로가기 [Article Type] Article
An Upgrade on the Surveillance System of SARS-CoV-2: Deployment of New Methods for Genetic InspectionSARS-CoV-2의 감시 시스템 업그레이드: 유전자 검사를 위한 새로운 방법 배포Article Published on 2022-03-152022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료기술, [키워드] Abnormal result Analysis analyzed consensus sequence country delta variant dominant equipment faster Genetic genetic surveillance information Inspection lack Mutation mutations New next generation sequencing NGS option Population positive qPCR qPCR variant screening. reported RT-qPCR SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variant identification screening test sequenced Surveillance System Upgrade variant variants [DOI] 10.3390/ijms23063143 PMC 바로가기 [Article Type] Article
Building the Momentum for A Stronger Pharmaceutical System in Africa아프리카에서 더 강력한 제약 시스템의 추진력 구축Article Published on 2022-03-112022-08-31 Journal: International Journal of Environmental Research an [Category] MERS, 치료제, [키워드] affected Africa Algeria building complex continent country Coverage COVID-19 COVID-19 pandemic Critical eight had more had no Health Kenya labelling Local Medicines momentum Morocco National Nigeria pharmaceutical pharmaceutical system strengthening. reflect Regulatory scaled solvent South Africa Structure System Vaccine Vaccines [DOI] 10.3390/ijerph19063313 PMC 바로가기 [Article Type] Article
Effectiveness of Covid-19 Vaccines over a 9-Month Period in North Carolina노스캐롤라이나에서 9개월 동안의 Covid-19 백신의 효과Article Published on 2022-03-102022-09-11 Journal: The New England Journal of Medicine [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval Ad26 Ad26.COV2.S B.1.617.2 BNT162b2 caused coronavirus disease Coronavirus disease 2019 COV2.S Cox regression model death declining delta variant dominant dose Effectiveness elapsed first dose Hospitalization Immunity increase in Infection Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 North of BNT162b2 outcome Period Pfizer-BioNTech postvaccination preventing infection provided recipient reducing regimen risk summer System the United State two-dose regimen United States vaccination Vaccine variant Viral particles [DOI] 10.1056/NEJMoa2117128 PMC 바로가기 [Article Type] Article
Identifying COVID-19 Outbreaks From Contact-Tracing Interview Forms for Public Health Departments: Development of a Natural Language Processing PipelineOriginal Paper Published on 2022-03-082022-10-31 Journal: JMIR Public Health and Surveillance [Category] Coronavirus, MERS, SARS, [키워드] 95% CI assist automated Cluster Clusters Contact tracing COVID-19 COVID-19 case database development Digital health digital surveillance tool Disease surveillance electronic surveillance form Health identify identifying intervals interview language Local Named entity recognition natural natural language processing neural language model objective outbreak Outbreaks Precision precision and recall processing Public public health public health informatics recall representation Result System targeted interventions transformer unique were measured [DOI] 10.2196/36119 PMC 바로가기 [Article Type] Original Paper
How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법Review Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation Acute kidney injury acute respiratory distress acute respiratory distress syndrome AMY-101 Angiogenesis apoptotic cells ARDS Biomarker bradykinin candidate drug candidate drugs cascade cascade system characterized chemokines Coagulation Coagulation system complement Complement inhibitor complement inhibitors Compound COVID-19 Crosstalk cytokine Cytokines damaged demonstrated dysregulation ecallantide eculizumab Evidence favor ground glass opacities heparin High dose high risk Icatibant IL-6 IL-6 levels in some incidence include Influenza influenza-like symptom Influenza-like symptoms inhibitor initiated Innate innate immune system intensive care treatment Kallikrein lanadelumab lead leukocytes life-threatening LMWH Lung injury mechanical ventilation mechanism moderate MOST oxygen oxygen saturation pandemic pathophysiology Patient patients Phase I plasma plasma proteins Platelets Potential predict Prevent Prognostic value pulmonary damage pulmonary inflammation receptor reduced Regulation respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 infected patient severity Support survival syndrome System systemic target the disease therapeutic option therapeutic options Thromboembolism thrombosis thrombotic Thrombotic complications translated Treatment treatment of COVID-19 Trial Usage Vascular ventilator virus [DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review