rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbitsrVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구Article Published on 2022-08-012022-09-11 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술, [키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed [DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article
Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance유전적 거리 분석을 통한 SARS-CoV-2 변이체의 증상 감염에 대한 COVID-19 백신 효과의 신속한 평가Article Published on 2022-08-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] 95% prediction interval accounted acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed applied circulating clinical trial collected Concordance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine delta variant Effectiveness Efficacy Genetic Genetic variant highest lowest mixed-effects model mRNA vaccine observational study offer omicron pandemic platform predict predicted Predictive protective effect Protective effects Public health responses Rapid real time Receptor-binding domain regions reported SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike protein symptomatic infection the receptor-binding domain the SARS-CoV-2 the vaccine Vaccine vaccine platform vaccine strain variant variants of concern virus [DOI] 10.1038/s41591-022-01877-1 PMC 바로가기 [Article Type] Article
Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera수포성 구내염 바이러스-SARS-CoV-2 키메라 기반 코로나19 후보 백신의 전임상 면역원성과 효능Article Published on 2022-08-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration AIDS approach authority candidate vaccine chimeric coding sequence coronavirus coronavirus disease cotton Cotton rat COVID-19 COVID-19 vaccine Department develop development dose Ebola virus Efficacy evaluated glycoprotein hamster hamsters Immunity immunogenic immunogenicity Inc Inc. initiative injection intramuscular lung mucosal Mucosal vaccination nasal nasal tissue New York Part Preclinical PROTECT reduce reduced replacing Research respond SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 vaccine Sharp significantly single vaccine spike stomatitis supported Syrian hamster the SARS-CoV-2 the vaccine threat tissues Transmission USA vaccination Vaccine vaccine candidate vesicular stomatitis vesicular stomatitis virus virus virus load VSV weight loss [DOI] 10.1016/j.ebiom.2022.104203 PMC 바로가기 [Article Type] Article
Predictors of seroconversion after coronavirus disease 2019 vaccination코로나 바이러스 질병 2019 예방 접종 후 혈청 전환 예측자Article Published on 2022-08-012022-09-12 Journal: Annals of allergy, asthma & immunology : official [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] active malignancy acute respiratory syndrome age and sex antibody assay Antibody Response B cell Characteristics clinical Clinical characteristics Clinical data collected coronavirus coronavirus disease COVID-19 COVID-19 vaccination defined demographic Efficacy evaluate exhibited greater immunodeficiency immunosuppressants Immunosuppression immunosuppressive immunosuppressive drug lack likelihood Male sex men Older age pandemic Patient Primary Immunodeficiency receiving response SARS-CoV-2 Seroconversion seronegative patient Spike protein steroid the SARS-CoV-2 the vaccine therapy vaccination Vaccine were assessed women [DOI] 10.1016/j.anai.2022.05.026 PMC 바로가기 [Article Type] Article
Is it safe and effective to administer COVID-19 vaccines during pregnancy? A systematic review and meta-analysisResearch article Published on 2022-08-012022-10-05 Journal: American journal of infection control [Category] SARS, 임상, [키워드] administer Admission adverse outcome adverse outcomes amniotic Analysis analyzed Blood consequence COVID-19 COVID-19 vaccination COVID-19 vaccine effective Effectiveness Efficacy evaluate fetal Future Hospitalization incidence Infection Meta-analysis Neonatal Neonatal COVID-19 objective observational study operative postpartum hemorrhage Pregnancy pregnant women Prevent Protective random effect Randomized Result Safe Safety SARS-CoV-2 infections searched stroke systematic review the vaccine Trial vaccination Vaccines vaginal delivery [DOI] 10.1016/j.ajic.2022.08.014 [Article Type] Research article
Development of a smartphone-based quantum dot lateral flow immunoassay strip for ultrasensitive detection of anti-SARS-CoV-2 IgG and neutralizing antibodiesAnti-SARS-CoV-2 IgG 및 중화항체의 초고감도 검출을 위한 스마트폰 기반 양자점 측방유동 면역분석 스트립 개발Article Published on 2022-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 IgG Antigen Blood donors common cold COVID-19 cross-reaction development diagnosed healthy blood donors human serum IgG immunoassay Inactivated vaccine Inactivated Vaccines individual Influenza influenza B inoculated lateral flow immunoassay Neutralizing antibodies neutralizing antibody nucleic acid nucleic acid test pandemic Patient patients with influenza platform populations positive proportion protective effect quantum Quantum dot reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike protein Smartphone Spike protein subunit vaccines the SARS-CoV-2 the vaccine the vaccines two patients Vaccine virus-neutralizing antibody was used Whole blood [DOI] 10.1016/j.ijid.2022.04.042 PMC 바로가기 [Article Type] Article
Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience성인 대상의 간질에 대한 COVID-19 백신의 영향: 이탈리아의 다심적 경험Observational Study Published on 2022-08-012022-09-11 Journal: Neurological Sciences [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Administered administration Adult patients age alcohol caffeine Characteristics clinic Cohort confidence interval coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines defined demonstrated epilepsy expressed Focal seizure Frequency generalized epilepsy Impact increase in interview Italian medication Multivariate analysis Observational cohort study occurred Outpatient Participants participated Patient Post-vaccine pre-vaccination questionnaire receive recruited SARS-COV-2 infection Seizure Seizures short term Side effect significantly stability STABLE the patient the vaccine Tolerability treated Treatment two groups Vaccine Variation worsening [DOI] 10.1007/s10072-022-06100-0 PMC 바로가기 [Article Type] Observational Study
Comparison of the post-marketing safety profile between influenza and COVID-19 vaccines: An analysis of the vaccine adverse event reporting systemResearch article Published on 2022-08-012022-10-05 Journal: Saudi Pharmaceutical Journal : SPJ [Category] 치료기술, [키워드] Adverse adverse effect adverse effects adverse event AEs Analysis conducted coronavirus disease COVID-19 COVID-19 vaccine Epidemic evaluate Frequency higher risk identify incidence incidence rate Influenza influenza vaccine influenza vaccines life-threatening event Mortality outcome recipient recipients reported Reporting retrieved retrospective Safety safety profile Symptoms System the vaccine Vaccine with COVID-19 [DOI] 10.1016/j.jsps.2022.06.009 [Article Type] Research article
Mycophenolate mofetil decreases humoral responses to three doses of SARS-CoV-2 vaccine in liver transplant recipientsMycophenolate mofetil은 간 이식 수혜자의 SARS-CoV-2 백신 3회 투여에 대한 체액 반응을 감소시킵니다.Article Published on 2022-08-012022-09-11 Journal: Liver international : official journal of the Inte [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95%CI Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody titre appear booster dose consultation decrease defined determine develop dose doses Efficacy enrolled Factor failure French Gender humoral Humoral response identify independent independent risk factor liver liver transplant male MMF mRNA mRNA vaccine mycophenolate mycophenolate mofetil Patient patients Predictive receiving recipient recipients responders response rate response to vaccination responsiveness risk factor Risk factors SARS-CoV-2 SARS-CoV-2 vaccine Serious Adverse Events Seroconversion Serologic response solid organ solid organ transplant the patient the vaccine Treatment vaccination Vaccine [DOI] 10.1111/liv.15258 PMC 바로가기 [Article Type] Article
Production and characterization of chimeric SARS-CoV-2 antigens based on the capsid protein of cowpea chlorotic mottle virus동백색 반점 바이러스의 캡시드 단백질을 기반으로 하는 키메라 SARS-CoV-2 항원의 생산 및 특성화Article Published on 2022-07-312022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] absence Antigen antigens BALB/c mice characterized chimeric Chimeric protein clinical evaluation COVID-19 pandemic Cowpea cultures develop E. coli Efficacy epitope Epitopes expressed expression full-length S protein Humoral response IgG antibody IgG antibody titer immunogenic Inclusion induce interfere mutant offer Pathogens plant plant virus Plant virus. Production Protein purified recognize resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein spike Spike protein subunit Subunit vaccine subunit vaccines Support the SARS-CoV-2 the vaccine Vaccine vaccine candidate vaccine candidates vaccine platform virus VLP VLPs [DOI] 10.1016/j.ijbiomac.2022.06.021 PMC 바로가기 [Article Type] Article