B 0 AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation AnalysisOriginal Research Published on 2021-05-132022-10-31 Journal: Function (Oxford, England) [Category] COVID-19, SARS, [키워드] 6M17 accompanied ACE2 acid Amino acid amino acid transporter angiotensin-converting enzyme-2 apical membrane approach AT1 B0AT1 coexpressed complex component conformation contribute COVID-19 COVID-19 patients dose Enterocyte expressed expression form functional Gut human tissues indicated Interaction intestine linear magnitude membrane membrane vesicle membranes mitigate molecular docking molecular weight Neutral neutral amino acid transport obligatory outbreak Particles persistence physiological purified Radiation radiation inactivation reported SARS-CoV-2 SARS-CoV-2 receptor small intestine sodium-dependent transport Symptom translational Transport transporter treat variant virion [DOI] 10.1093/function/zqab027 PMC 바로가기 [Article Type] Original Research
Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patientsCOVID-19 환자를 위한 임상 및 가정 환경에서 호흡기 바이오마커 및 바이탈 사인에 대한 자동화된 다중 매개변수 모니터링Clinical Trial Published on 2021-05-112022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 임상, 진단, [키워드] (heart rate ambient approach automated Biomarker Biomarkers biometrics can be used can not capture Care Continuous continuous monitoring Conventional Convolutional neural networks correlation correlations cough coughing Course COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic COVID-19 patient COVID-19 patients Data analysis demographic groups Digital health disease disease spread Diseases effort events feature Frequency Health care health care workers Health status healthy control healthy controls healthy individual heart rate high fidelity high risk hospital Immunity individual Infection Infectious diseases infectiousness intensity limitations methodology monitoring system overcome parameter Patient physiological populations Probability quantitative measurement respiratory respiratory activity Respiratory disease respiratory rate response sick Significance Soft Spread temperature Therapeutics translational Trial Variation vital sign vital signs wearable electronics [DOI] 10.1073/pnas.2026610118 PMC 바로가기 [Article Type] Clinical Trial
Rotavirus as an Expression Platform of Domains of the SARS-CoV-2 Spike ProteinArticle Published on 2021-05-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered cassette children coding coding sequence COVID-19 vaccine domain double-stranded RNA expected Express expressed expression vector feasibility FLAG-tagged full-length S gastroenteritis Generation Genome highest immunoblotting immunogenic insertion introduced kDa N-terminal domain NTD RBD Reoviridae required reverse genetics RNA rotavirus rotavirus vaccine S protein S-protein SARS-CoV-2 sequence spike Spike protein the SARS-CoV-2 translational Vaccine variant virus [DOI] 10.3390/vaccines9050449 PMC 바로가기 [Article Type] Article
Assessing the impact of COVID-19 on registered interventional clinical trials등록된 중재 임상 시험에 대한 COVID-19의 영향 평가Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 임상, [키워드] Assessing clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 pandemic Registered Sponsor submitted translational Trial [DOI] 10.1111/cts.13034 PMC 바로가기 [Article Type] Article
Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus BiologyReview Published on 2021-04-132022-10-28 Journal: Viruses [Category] COVID-19, [키워드] (+)RNA viruses affinity purification liquid chromatography coupled to mass spectrometry (AP-LC-MS/MS) alphaviruses Antiviral approach Biology bottom-up proteomics cellular complex complexes Coronaviruses Critical Effect flaviviruses function functions high mortality Host host responses human disease identify implication information macromolecular mass spectrometry morbidity Pathogenesis Perturbation post-translational modifications Protein protein complexes Replication RNA RNA virus screening method Sequencing Streamline structural proteomics targets top-down proteomics translational unique Viral protein virus [DOI] 10.3390/v13040668 PMC 바로가기 [Article Type] Review
Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes성인 인간 원발성 심근세포에서 Hydroxychloroquine, Chloroquine 및 Azithromycin의 심장독성 가능성Article Published on 2021-04-122022-09-11 Journal: Toxicological sciences : an official journal of th [Category] SARS, 치료제, [키워드] adult human primary cardiomyocyte Azithromycin cardiac toxicity caused changed Channel block Chloroquine Clinical studies clinical study Combination Concentration concentrations contractility coronavirus coronavirus disease COVID-19 develop drug Effect effort elevated elevated temperature evaluated exhibiting Features high risk Human humans Hydroxychloroquine impacted Inflammatory diseases malaria mechanism medications Potential proarrhythmia risk promoted repurposed therapies risk safety profile therapeutic therapy translation translational Treatment [DOI] 10.1093/toxsci/kfaa194 PMC 바로가기 [Article Type] Article
Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19Article Published on 2021-04-052022-10-28 Journal: Patterns [Category] COVID-19, [키워드] Abstract Analysis association biological processe build changes Cluster Community Consensus coronavirus COVID-19 Data integration Data mining data-driven disease disease models driving elements feature Features functional Gene Expression gene expression signature gene signature Genome-wide association study heterogeneous host protein hypotheses Identified identify information Interaction interactions joint knowledge Meta-analysis model system module detection molecular molecular mechanism multiple model system network analysis outcome outcomes overcome pathophysiological pathophysiology pathway pattern search phenotype protein-protein interaction Research question SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome secondary Single-cell RNA-sequencing Standard Support transcriptional Transcriptome transcriptomic transcriptomics translational utility viral-host protein [DOI] 10.1016/j.patter.2021.100247 PMC 바로가기 [Article Type] Article
RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving FieldReview Published on 2021-04-042022-10-31 Journal: Cancers [Category] COVID-19, [키워드] αvβ3 αvβ6 accumulated Angiogenesis approach approaches binding Cancer cancer progression Cell cells Clinical studies clinical trials compounds diagnostic disease dose elevated Exosomes expression fibrosis field function functions high accuracy integrin integrin targeted therapy Integrins investigated knowledge Ligand ligands Metastasis molecular molecular imaging motif non-cancerous novel nuclear optical other diseases patient selection pharmacological progression receptors respiratory RGD-binding integrins SARS-CoV-2 SARS-COV-2 infection selective Sepsis Signal transduction simple subtype Subtypes synthetic synthetic integrin ligands target therapeutic target therapeutic targets therapy translation translational Treatment protocol treatment strategy Trial vascular normalization therapy viral infections [DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review
Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challengeSARS-CoV-2 전염병 동안 동물 및 임상 연구 연결: 새로운 도전Review Published on 2021-04-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 비임상, 임상, 치료제, [키워드] accelerate animal model breath Bridging clinical evidence Clinical studies Clinical treatment clinical trial COVID-19 domain drug and vaccine development effort highlight human diseases limitation medical history pandemic Pandemics Pre-clinical research Research resource SARS-CoV-2 SARS-CoV-2 pandemic status strained synergy translational Trial utility Vaccine Vaccine development [DOI] 10.1016/j.ebiom.2021.103291 PMC 바로가기 [Article Type] Review
Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems리포솜 및 고분자 약물 전달 시스템의 합성 및 평가에서 로봇 공학, 미세 유체 공학, 나노 기술 및 AIArticle Published on 2021-04-012022-08-31 Journal: Drug delivery and translational research [Category] 치료제, [키워드] approach artificial artificial intelligence automated Automation cell type cell types changes in COVID-19 pandemic database drastic Efficiency experiments extension globe Laboratory Liposome Microfluidics Nanotechnology patients personalised Personalised medicine Perspective robotics therapeutic traditional methods translational unique [DOI] 10.1007/s13346-021-00929-2 PMC 바로가기 [Article Type] Article