Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort studyResearch Published on 2021-04-262022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress affected analyzed clinical cohort study Comorbidities competing conducted COVID-19 COVID-19 patients COVID19 Critically ill demographics difference disease evaluate evaluated Evidence group ICU IMPROVE increasingly lung lung recruitment maintain mechanical ventilation mechanically ventilated mechanisms median Mortality no difference non-responder outcome Oxygenation oxygenation response PaO Patient physiological prone prone positioning reduced regression analysis Respiratory mechanics Responder responders Result risk Severity Score Supine position supplementary material survival sustained syndrome the SARS-CoV-2 Treatment variables Variation ventilation/perfusion ventilatory Ventilatory free days [DOI] 10.1186/s13613-021-00853-1 PMC 바로가기 [Article Type] Research
Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or TocilizumabDexamethasone 또는 Tocilizumab으로 치료하는 인공호흡기를 사용하는 중환자 COVID-19 이집트 환자의 단기 생존Randomized Controlled Trial Published on 2021-04-232022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI Admission approved assigned assisted ventilation clinical comparable consolidation COVID-19 COVID-19 patient COVID-19 patients Cox regression analysis Critically ill critically ill COVID-19 patients CT chest CT chest pattern D-dimer Data collection Dexamethasone ferritin ground glass pattern groups Kaplan–Meier survival analysis lymphocyte mechanical ventilation Mortality Nal protocol neutrophil neutrophil/ lymphocyte ratio non-invasive ventilation on mechanical ventilation PaO Participation Patient patients predicted Probability pulse Randomly risk factor Risk factors severe COVID-19 Sex short term short-term survival survival survival analysis TCZ therapy Tocilizumab treated Treatment Trial registration Vasopressor [DOI] 10.1038/s41598-021-88086-x PMC 바로가기 [Article Type] Randomized Controlled Trial
A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trialSARS-CoV-2 유발 급성 호흡곤란 증후군에 대한 정맥내 혈장 정제 알파-1 항트립신의 무작위 이중 맹검 위약 대조 파일럿 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-192022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hours active malignancy acute kidney Acute kidney injury acute respiratory distress syndrome addition Administered administration adverse event adverse events AEs age Alpha alpha-1 antitrypsin Amendment Anti-viral Antibiotics anticipated antitrypsin antivirals approval approved ARDS ARMS authority bacterial pneumonia baseline Berlin criteria blinded to treatment Blinding BMI body weight Cancer changes in Child-Pugh score chloride Chronic kidney disease chronic liver disease circulating class clinical Clinical outcome clinical trial Combination commenced Committee comparator Complete conducted Consent Controlled trial correction COVID-19 Culture cytokine level cytokine levels Data collection defined determine Diagnosis diagnosis of ARDS dialysis dissemination DNAR double-blind Echocardiogram Effect Effectiveness elapsed element ELISA enrolled EudraCT excluded exclusion exclusion criteria facilitate Follow-up followed by for inclusion group Health Products regulatory Authority hospital Hospital admission hypertension ICU IgA deficiency IL-10 IL-1β IL-6 IL-8 incidence inclusion criteria individual information intensive care unit intensive care units interim analysis interleukin interleukin-10 interleukin-1β interleukin-6 interleukin-8 interpreter Intervention intravenous intravenous infusion intravenously invasive investigational medicinal product investigator Ireland Kidney disease Laboratory laboratory-confirmed life Local maintain major trauma malignancy mandatory marker mechanical ventilation Microscopy moderate moderate to severe Mortality Non-invasive non-invasive mechanical ventilation non-invasive ventilation number objective occur Organ failure outcome outcome measure PaO participant Patient patient recruitment patients with moderate PCR-confirmed Phase 2 physician Placebo placebo-controlled plasma plasma analysis plasma concentration plasma concentrations pregnant preparation product protocol provided Pulmonary embolism pulmonary hypertension purified Radiographic randomisation randomisation list randomised randomised controlled trial rationale readmission REC receiving receptor recruited recruitment reduce Regulatory removal renal renal replacement therapy replacement therapy reported required Research Research Ethics Research Ethics Committee research nurse research nurses respiratory respiratory distress Respiratory distress syndrome resulting Resuscitation SAE SAEs Sample size SARS-CoV-2 secondary secondary bacterial pneumonia Secondary objective Secondary objectives Secondary outcomes secretion Sequential Organ Failure Assessment Serious Adverse Event Serious Adverse Events severe ARDS Shock single dose skin cancer Sodium chloride SOFA Standard statistician stratified study participation Study protocol subject submitted supplementary material Support sustained TNF TNF-α Tolerability trauma Treatment treatment allocation Trial trial protocol Trial registration vasopressors ventilator verbal Version Volume website WHO Withdrawal writing [DOI] 10.1186/s13063-021-05254-0 PMC 바로가기 [Article Type] Letter
Admission High-Sensitive Cardiac Troponin T Level Increase Is Independently Associated with Higher Mortality in Critically Ill Patients with COVID-19: A Multicenter StudyArticle Published on 2021-04-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] cardiac cardiac troponin case mix conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill French high-sensitive cardiac troponin T ICU ICU admission ICUs Ill in-hospital mortality increase increases in index intensive care unit involved laboratory-confirmed Level male mechanically ventilated median age Mortality multicenter multicenter study myocardial injury outcomes PaO Patient patients Physiology previous study Prognostic value renal replacement therapy reported retrospective cohort study risk stratification SARS-CoV-2 score Serum level serum levels the median treated troponin T [DOI] 10.3390/jcm10081656 PMC 바로가기 [Article Type] Article
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patientsResearch Published on 2021-04-062022-11-01 Journal: Critical Care [Category] COVID-19, MERS, [키워드] adopted applied carbon caused clinical cohort study collected Compliance conducted COVID-19 COVID-19 pandemic defined died dioxide Effect had more ICU ICU admission intensive care unit Intubated Invasive mechanical ventilation invasively ventilated patient Italian Limited majority mechanical ventilation mechanically ventilated patient Mild moderate Mortality multicentre National no difference Older outcome Oxygenation pandemic PaO Patient patients prone Prone position prone positioning Refractory hypoxemia Respiratory failure Respiratory system Result resulting severe ARDS severe disease severe respiratory failure significant increase significantly more subset supplementary material treat Ventilation ventilatory was collected was performed was reduced [DOI] 10.1186/s13054-021-03552-2 PMC 바로가기 [Article Type] Research
COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational studyObservational Study Published on 2021-04-012022-10-05 Journal: Journal of critical care [Category] SARS, 임상, [키워드] ARDS ARDS patient COVID-19 CRP greater highlight immunological phenotype implication Inflammation low dose low-dose PaO Patient physiological retrospective statistically significant steroid treatment Steroids with COVID-19 [DOI] 10.1016/j.jcrc.2020.11.012 PMC 바로가기 [Article Type] Observational Study
PaO 2 /FiO 2 and IL-6 are risk factors of mortality for intensive care COVID-19 patientsArticle Published on 2021-04-012022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료법, [키워드] 95% confidence interval analyzed AUC chest imaging Chi-square coronavirus disease COVID-19 COVID-19 patient dead death in COVID-19 died Huoshenshan Hospital ICU ICUs identify IL-6 independent risk factor independent risk factors intensive care intensive care unit interleukin-6 involved Laboratory logistic regression model Medical research Mortality oxygenation index PaO Patient patients Retrospective analysis Retrospective study risk factor Risk factors student survived Survivors t-test tested the patient variables were used [DOI] 10.1038/s41598-021-86676-3 PMC 바로가기 [Article Type] Article
Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian PandemicMedicine Published on 2021-03-252022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Admission affected Anesthesia baseline body mass index Characteristics clinical Co-infection contribute coronavirus COVID-19 death disease European country fatality Health Service hemoglobin hospital Hospitalization hospitals identify Infection information Intensive intensive care intensive care unit intubation investigated Italian Italy lombardy Lungs Mortality multiple organ failure occurred Occurrence outcome pandemic PaO Patient predictors resources SARS-CoV-2 Sepsis Septic shock Seven severe coronavirus disease severe COVID-19 Support systemic inflammatory response syndrome the disease the patient worsening [DOI] 10.3389/fmed.2021.582896 PMC 바로가기 [Article Type] Medicine
The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcomeCOVID-19 결과 예측에서 심장 손상, 염증 및 응고 사이의 관계Article Published on 2021-03-222022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] abnormality adverse outcome anticoagulation treatment association attenuate attenuation benefit change Coagulation Coagulopathy Complication confounders consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CRP D-dimer determinant Effect Endpoint enrolled greater heparin Hospitalized In-hospital individuals Inflammation Inflammatory Inflammatory response Injury low molecular weight low molecular weight heparin mechanism Mortality observational study outcome PaO pathway Pneumonia Predictive markers primary endpoint Prognostic markers risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia sensitivity severity single-center subject therapy Treatment troponin T [DOI] 10.1038/s41598-021-85646-z PMC 바로가기 [Article Type] Article
Covid-19 and gender: lower rate but same mortality of severe disease in women—an observational studyObservational Study Published on 2021-03-202022-10-04 Journal: BMC Pulmonary Medicine [Category] Fulltext, SARS, 임상, [키워드] 28-day mortality Admission Affect age Bergamo Clinical course clinical feature collected Continuous COVID-19 CPAP death disease severity Factor female Gender Hospitalization independent Italy Kaplan–Meier survival analysis Laboratory less male males men men and women Mortality multivariable analysis Myocardial infarction non-invasive ventilation observational study outbreak outcome PaO parameter Patient patients patients hospitalized pressure radiological Result risk severe disease significant difference smoking supplementary material Treatment women [DOI] 10.1186/s12890-021-01455-0 PMC 바로가기 [Article Type] Observational Study