Drug-induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies2019년 코로나바이러스 질병의 약물 유발 장기 손상 약물 요법: 감별 진단 및 잠재적 보호 전략의 메커니즘 및 과제Review Published on 2021-07-012022-09-11 Journal: Journal of biochemical and molecular toxicology [Category] 바이오마커, 치료제, [키워드] adverse effect adverse effects Adverse reaction Adverse reactions Antiviral antiviral drug Biomarker caused clinical complication clinical manifestation clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection differential diagnosis Diseases drug drug regimen drug-induced drug-induced organ injury Emerging infectious diseases facilitate global public health Health Organization heart highlight highly pathogenic in some increasingly Infectious diseases Inflammation information kidney liver management mechanisms organ organ injury organs outbreak outcome oxidative oxidative stress pandemic Protective SARS-CoV-2 virus Side effect Therapeutic strategies therapeutic strategy Viral viral infection World Health Organization [DOI] 10.1002/jbt.22795 PMC 바로가기 [Article Type] Review
Clinical studies assessing the efficacy, effectiveness and safety of remdesivir in management of COVID-19: A scoping reviewCOVID-19 관리에서 렘데시비르의 효능, 효과 및 안전성을 평가하는 임상 연구: 범위 검토Review Published on 2021-07-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] accumulated accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse event adverse events Adverse reaction Antiviral association clinical Clinical improvement clinical status clinical trial conducted control groups coronavirus COVID COVID 19 COVID-19 decreased mortality Effectiveness Efficacy Efficacy and safety Evidence expected GS 5734 hepatic impairment Hospitalized increased survival Intervention management Median recovery time observational studies observational study OVID Participants Patient patients patients with COVID-19 proportion quantitative synthesis randomized-controlled Recovery time Registered Remdesivir reported Repurposed drug Repurposed drugs SARS-CoV-2 scoping review searched severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 treat treated Treatment Trial trials [DOI] 10.1111/bcp.14677 PMC 바로가기 [Article Type] Review
Comparing Results of Five SARS-CoV-2 Antibody Assays Before and After the First Dose of ChAdOx1 nCoV-19 Vaccine among Health Care Workers의료 종사자들 사이에서 ChAdOx1 nCoV-19 백신의 첫 번째 접종 전후의 5가지 SARS-CoV-2 항체 분석 결과 비교Immunoassays Published on 2021-06-302022-09-12 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, [키워드] Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse reaction Adverse reactions All participants antibody Antibody assays Antibody titer Antibody titers applied assay assays AstraZeneca AZ vaccine baseline ChAdOx1 nCoV-19 conducted contribute coronavirus correlation correlations Cutoff Day Efficacy Factor first dose FIVE Genscript help Laboratory Participants questionnaire Result Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SD Biosensor sera serum sample serum samples severe acute respiratory syndrome Coronavirus severe adverse reactions severity Siemen significantly higher single dose Spread Symptoms tested titer vaccination Vaccine Virus neutralization worker [DOI] 10.1128/JCM.01105-21 PMC 바로가기 [Article Type] Immunoassays
Effects of Self-focused Augmented Reality on Health Perceptions During the COVID-19 Pandemic: A Web-Based Between-Subject ExperimentRandomized Controlled Trial Published on 2021-06-292022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] 95% CI addition adverse effect Adverse reaction Analysis assigned augmented reality Care condition conducted control condition control group COVID-19 COVID-19 pandemic Effect effective experiment hand hygiene Health Health Behavior human-computer interactions Intention Intervention measure objective participant Perception predictor Psychological Randomly REALITY Result scored self-focused attention severity susceptibility vicarious vicarious reinforcement while [DOI] 10.2196/26963 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Safety of COVID-19 Vaccinations—We Should Rethink the PolicyArticle Published on 2021-06-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% confidence interval Adverse Adverse drug reaction Adverse reaction benefit calculated COVID-19 COVID-19 vaccine database death drug EMA European Medicines Agency fatal side effects Government lack mRNA vaccine mRNA-vaccine number needed to vaccinate Pfizer Policy Prevent prevented reaction reported Result risk Safety SARS-CoV2 Side effect Side effects vaccinate vaccination Vaccinations [DOI] 10.3390/vaccines9070693 PMC 바로가기 [Article Type] Article
COVID-19 Vaccine Hesitancy and Its Associated Factors in JapanArticle Published on 2021-06-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adverse reaction analyzed calculated comparable conducted COVID-19 COVID-19 vaccine cross-sectional Factor Factors female Hesitancy identify Internet Japan Japanese longitudinal study lowest male measure Odds ratio Older previous study proportion Psychological distress response robust Sex social determinants of health socioeconomic status statistical Vaccine Vaccine hesitancy [DOI] 10.3390/vaccines9060662 PMC 바로가기 [Article Type] Article
Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After VaccinationImmunology Published on 2021-06-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adverse reaction Biomarker Control coronavirus disease creating cytokine Cytokines Diseases Efficacy EVs expected expression extracellular vesicle IL-12 IL-6 IL-6 expression IL-6-dependent immune response IMPROVE individual individuals Inflammatory Innate immunity Local lymphoid cells mice microRNA miR-21 miRNA miRNAs negative feedback loop predict Prophylaxis reduce reducing regulate required response seasonal flu serum Symptom Th1 type I interferon vaccination vaccination efficacy Vaccinations Vaccine [DOI] 10.3389/fimmu.2021.685344 PMC 바로가기 [Article Type] Immunology
Proteome Profiling of Recombinant DNase Therapy in Reducing NETs and Aiding Recovery in COVID-19 PatientsResearch Published on 2021-06-152022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID-19, [키워드] Abstract accumulation acute respiratory distress Adverse reaction AF, Alexa Fluor airway airways analyses Analysis approved ARDS, acute respiratory distress syndrome blood plasma CF, cystic fibrosis change clinically components contribute coronavirus disease COT, conventional oxygen therapy COVID-19 COVID-19 disease COVID-19, Coronavirus disease 2019 DAPI, 4,6 diamidino-2-phenylindole DIA-MS, data-independent acquisition MS DNA DNase ECMO, extracorporeal membrane oxygen therapy extracellular DNA FDR, false discovery rate FiO2, fraction of inspired oxygen FIVE GGO, glass ground opacity hallmark hemorrhage HFNO, high-flow nasal oxygenation high-flow oxygen therapy hindrance Hypoxemia immunofluorescence implication IMPROVE infections Inflammation iRT, indexed retention time peptides Lung function mass spectrometry Microscopy NE, neutrophil elastase NET NET, neutrophil extracellular trap NETs Neutrophil extracellular trap oxygen saturation Oxygenation PADI-4, peptidyl arginine deiminase IV Patient patients plasma Pneumonia Profiling proteome pulmonary inflammation Quantitative recombinant reduce reduced reducing reduction Respiratory failure rhDNase, recombinant human DNase I Roche SARS-CoV2, severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients Severe patient severely ill patient shown SpO2, the oxygen saturation as measured by pulse oximetry sputum statistically significant Symptom syndrome systemic inflammatory targeting the disease therapeutic therapy treated Treatment with COVID-19 [DOI] 10.1016/j.mcpro.2021.100113 PMC 바로가기 [Article Type] Research
Adverse reactions of drugs specifically used for treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 치료에 특별히 사용되는 약물의 부작용Comment Published on 2021-06-112022-09-11 Journal: Medicina clínica [Category] MERS, SARS, 치료제, [키워드] Adverse reaction drug SARS-COV-2 infection Treatment [DOI] 10.1016/j.medcli.2020.12.013 PMC 바로가기 [Article Type] Comment
High-throughput framework for genetic analyses of adverse drug reactions using electronic health records전자 건강 기록을 사용한 부작용 반응의 유전자 분석을위한 고 처리량 프레임 워크Research Article Published on 2021-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] added ADR ADRS Adverse drug reaction Adverse drug reactions Adverse reaction Adverse reactions allergy Analysis approach association associations Biobank clinical guideline Clinical guidelines common diseases conducted CYP2D6 develop DNA drug Drug allergy drug response Electronic health record Electronic health records eligible patient Eligible patients Evidence expression genetic association genetic associations genetic loci Genetic studies genetic study Genetic variation Genome-wide association studies Genome-wide association study group GWAS Healthcare system help identify IMPROVE individual less loci opioid OPRM1 pathophysiological mechanism pathophysiological mechanisms phenome physiological Precision proof Quantitative recorded Research response sample sizes understanding university [DOI] 10.1371/journal.pgen.1009593 PMC 바로가기 [Article Type] Research Article