SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study국가 covid-19 혈청유병률 조사에 사용 가능한 SARS-CoV-2 측면 흐름 분석(React 2): 진단 정확도 연구Research Published on 2021-03-022022-09-10 Journal: The BMJ [Category] Fulltext, SARS, 진단, 치료기술, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis antibody Antibody titre antibody titres antigen binding antigen binding assay clinical sample Clinical use clinics cohorts college community transmission coronavirus coronavirus disease Coronavirus disease 2019 diagnostic Diagnostic accuracy enzyme evaluate evaluated finger Finger prick IgG immunoassay Immunoglobulin Immunoglobulin G Inclusion Infection Laboratory laboratory analyses Laboratory analysis lateral flow lateral flow immunoassay LFIA LFIAs London lowest minimum National NHS objective outcome measure PanBio participant performed positive sample real time Reference standards respiratory Result SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity analyses Sensitivity and specificity sera seroprevalence survey serum serum sample serum samples setting Seven significantly higher Spike protein Surescreen tested titre United Kingdom were used [DOI] 10.1136/bmj.n423 PMC 바로가기 [Article Type] Research
Low clinical performance of the Isopollo COVID-19 detection kit (M Monitor, South Korea) for RT-LAMP SARS-CoV-2 diagnosis: A call for action against low quality products for developing countriesRT-LAMP SARS-CoV-2 진단을 위한 Isopollo COVID-19 검출 키트(M Monitor, 한국)의 낮은 임상 성능: 개발도상국을 위한 저품질 제품에 대한 조치 촉구Article Published on 2021-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused Chain Reaction clinical evaluation clinical sample clinical samples Clinical use conducted coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Diagnosis drug Drug administration Ecuador Emergency evaluate evaluated food gold gold standard Isopollo COVID-19 isothermal amplification lack Loop-mediated isothermal amplification mandatory molecular Multiple pandemic polymerase chain polymerase chain reaction protocol regulatory agencies regulatory agency reverse transcription reverse transcription polymerase chain reaction RT-LAMP RT-PCR SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus South Korea the SARS-CoV-2 [DOI] 10.1016/j.ijid.2020.12.088 PMC 바로가기 [Article Type] Article
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice엔도솜 산성화 억제제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스에서 바이러스성 폐렴을 완화합니다Research Published on 2021-02-272022-09-10 Journal: Virology Journal [Category] MERS, 치료기술, 치료제, [키워드] 293T 293T-ACE2 cells acidic pH alveolar Analysis Antiviral effect antiviral effects bafilomycin Bafilomycin A1 caused CCK-8 CCK-8 assay Cell Chloroquine Clinical use coronavirus disease Coronavirus disease 2019 COVID-19 detect distribution Drug development Endosomal acidification endosome Endosomes eosin evaluate global pandemic hACE2 hematoxylin Huh-7 In situ hybridization Infection infiltration Inflammatory inhibitor inhibitors investigated lung tissue lung tissues pathological change peribronchiolar perivascular tissues Pneumonia proliferation provide reduced Replication Research Result RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly staining Structure suppress the SARS-CoV-2 transgenic mice used to evaluate Vero E6 Vero E6 cell VERO E6 cells viability Viral Viral pneumonia viral replication was used [DOI] 10.1186/s12985-021-01515-1 PMC 바로가기 [Article Type] Research
Health Care Professionals’ Confidence and Preferences for Diagnostic Assays for SARS-CoV-2: A Global StudySARS-CoV-2 진단 분석에 대한 의료 전문가의 자신감과 선호: 글로벌 연구Public Health Published on 2021-02-262022-09-12 Journal: Frontiers in Public Health [Category] MERS, 진단, [키워드] Accuracy Antibody testing Antigen Care Characteristics Clinical use confidence Consensus correlated country COVID-19 COVID-19 pandemic COVID-19 test COVID-19 tests determine diagnostic diagnostic test diagnostics disease disease symptoms global health group had no hcp Health immune response infection with SARS-CoV-2 Mortality National PCR testing performed Perspective positive preference professional Result SARS-CoV-2 Serological testing Support [DOI] 10.3389/fpubh.2021.569315 PMC 바로가기 [Article Type] Public Health
Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance입원 시 실험실 결과를 사용한 COVID-19 심각도 예측: 유익한 값, 임계값, ML 모델 성능Article Published on 2021-02-262022-08-31 Journal: BMJ Open [Category] MERS, 바이오마커, [키워드] 95% CI activated activated partial thromboplastin time admitted to ICU Alanine alanine aminotransferase Algorithm aPTT aspartate Aspartate aminotransferase AUC Bilirubin Biochemistry bioinformatics Biomarker Biotechnology biotechnology & C reactive protein Clinical use comparable consecutive patient COVID-19 COVID-19 severity creatine creatine kinase CRP cut-off cut-off threshold D-dimer dataset Deterioration disease severity disproportion Dubai Features ferritin fibrinogen Free ICU identify Infectious diseases information information technology intensive care intensive care unit Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lymphocyte Lymphocyte count ML model non-severe cases online tool partial thromboplastin time Patient PCR predict prediction Predictive Prognosis prognosis of patient respiratory respiratory infections returned risk Stratification study cohort subjects threshold threshold value thresholds THROMBOPLASTIN total bilirubin troponin with COVID-19 worsening [DOI] 10.1136/bmjopen-2020-044500 PMC 바로가기 [Article Type] Article
In silico evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main proteaseOriginal Research Article (Experimental) Published on 2021-02-252022-10-30 Journal: Journal of Ayurveda and Integrative Medicine [Category] COVID-19, [키워드] 2019-nCoV 6LU7 Abstract Analysis Anti-inflammatory anti-viral drug approved AutoDock AYUSH-64 binding energy Clinical studies Clinical use complex Compound conducted Corona Council COVID-19 Cys145 disease docked drug drug target Dynamics simulations enzyme Epidemic evaluate exhibit health emergency highest HIS164 identify Image in silico India ingredient Interaction Ligand M pro main protease management material molecular molecular docking molecular dynamics Molecular dynamics simulation objective pandemic PDB performed positive potential treatment option protease Public residues respiratory Result SARS-CoV-2 screened selected stability the disease the SARS-CoV-2 Vaccine were used [DOI] 10.1016/j.jaim.2021.02.004 PMC 바로가기 [Article Type] Original Research Article (Experimental)
Proposal of selective wedge instillation of pulmonary surfactant for COVID-19 pneumonia based on computational fluid dynamics simulationTechnical Advance Published on 2021-02-222022-10-28 Journal: BMC Pulmonary Medicine [Category] COVID-19, [키워드] airway alveolar Alveolar collapse ARDS assigned assumed Bronchiole bronchioles Bronchoscopic therapy calculated caused Cell Clinical use clinically Concentration COVID-19 Diffuse alveolar damage distress driving dysfunction effective End-Expiratory Pressure human airway interstitial pneumonia investigated lobular Lung fibrosis observation performed Pneumonia Prevent Pulmonary edema Region regions replaced Result secrete selective subsegmental syndrome therapy Type Type II pneumocyte Vascular ventilator was determined Wedge pressure [DOI] 10.1186/s12890-021-01435-4 PMC 바로가기 [Article Type] Technical Advance
Serum Amyloid A in Inflammatory Rheumatic Diseases: A Compendious Review of a Renowned Biomarker염증성 류마티스 질환의 혈청 아밀로이드 A: 저명한 바이오마커에 대한 포괄적인 검토Review Published on 2021-02-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] Activation acute phase amyloid A amyloidosis arising Arthritis autoinflammatory disease biological therapy Biomarker Biomarkers C-reactive protein C-reactive protein (CRP cascade clinical Clinical practice Clinical use clinical utility collected coronavirus disease Coronavirus disease 2019 COVID-19 database Disease activity disease severity erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluated immune system Immunotherapy Inflammasome Inflammation Inflammatory interleukin interleukin 17 isoform lead management markers of inflammation mechanism Pathogenesis Patient patients producing Protein proteomic recent finding recruitment review rheumatic disease Rheumatic diseases rheumatic inflammatory disease rheumatoid arthritis SAA secondary amyloidosis sedimentation rate serum amyloid serum amyloid A severe coronavirus disease shown T helper cells target therapeutic strategy utility [DOI] 10.3389/fimmu.2020.631299 PMC 바로가기 [Article Type] Review
Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors Research Published on 2021-02-172022-10-05 Journal: Nature cancer [Category] 변종, 유전자 메커니즘, [키워드] Cancer cascade children clinical Clinical use Diagnosis DNA sequencing dominant downstream Genes genetics germline individual moderate pathogenic Patient pediatric positive result predisposition Prospective reported reproductive risk reduction solid tumor Therapies translation undergo variant [DOI] 10.1038/s43018-021-00172-1 [Article Type] Research
Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19Immunology Published on 2021-02-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accelerated alteration Antiviral effect application autophagy Azithromycin benefit clearance Clinical use contribute Course COVID-19 COVID-19 immune response COVID-19 pandemic Cytokine storm death defined early stage Effect effective Efficacy Evidence Factor function identify immune mechanism immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory therapy immunosuppressive Infection Inflammation inflammatory cell infiltration investigated late stage Lung pathology macrophages mechanism Multiple neutrophil patients patients with COVID-19 Potential pro-inflammatory cytokine progression pursuit Regulatory severe disease shown Stage Support the disease therapeutic therapy viral burden virus while [DOI] 10.3389/fimmu.2021.574425 PMC 바로가기 [Article Type] Immunology