SperoPredictor: An Integrated Machine Learning and Molecular Docking-Based Drug Repurposing Framework With Use Case of COVID-19SPEROPDICTOR : COVID-19의 사용 사례와 함께 통합 된 기계 학습 및 분자 도킹 기반 약물 재검사 프레임 워크Article Published on 2022-06-162022-08-31 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] Accuracy association candidate clinically collected contagious contagious disease coronavirus costly COVID-19 data analytics database databases dataset de novo death disease drug drug candidate Drug discovery Drug repurposing effective effort Extensive FDA approval FDA-approved drug FDA-approved drugs feature Features followed by forest framework generic drug Gradient Host host proteomes human host indicated inefficient machine learning molecular docking pandemic Pandemics platform predicted proteome Random forest rapid response reduce repurposing Research resulting SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 Spread spread of COVID-19 systematic review Threats Traditional tree trees variant [DOI] 10.3389/fpubh.2022.902123 PMC 바로가기 [Article Type] Article
Prevalence of suicidality in clinically stable patients with major depressive disorder during the COVID-19 pandemicObservational Study Published on 2022-06-152022-10-05 Journal: Journal of affective disorders [Category] 임상, [키워드] 95%CI age Analysis Binary logistic regression Clinical data clinically conducted confidence interval COVID-19 COVID-19 pandemic cross-sectional depressive depressive symptom disorder eligibility criteria examined Gender hospitals ideation increased risk information Major major depressive disorder male mental health problem Pain pandemic participant Patient physical Prevalence preventive measure provided Psychiatric Regular risk severe fatigue subpopulations Suicidality urban were recorded [DOI] 10.1016/j.jad.2022.03.042 PMC 바로가기 [Article Type] Observational Study
Glycaemic variability is associated with all-cause mortality in COVID-19 patients with ARDS, a retrospective subcohort study Research Published on 2022-06-142022-10-05 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료법, [키워드] Aachen acute respiratory distress adjusted all-cause mortality ARDS caused clinically cohort study confounders Continuous coronavirus disease COVID-19 COVID-19 mortality COVID-19 patient death diabete diabetes elevated Factor Germany Glucose high mortality ICU ICU admission increase in intensive care Kaplan–Meier estimator likelihood mechanical ventilation median Metrics moderate Mortality mortality risk P/F ratio Patient patients with COVID-19 plasma procalcitonin retrospective severe ARDS significant increase statistically significant difference survival syndrome university Variability with COVID-19 [DOI] 10.1038/s41598-022-13816-8 [Article Type] Research
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19Review article Published on 2022-06-132022-10-05 Journal: The Lancet. Respiratory Medicine [Category] 바이오마커, 신약개발, 임상, [키워드] acutely ill patient Care clinical care clinical trials Clinical use clinically conducted COVID-19 detect disadvantage Effect Efficiency evaluate Hydroxychloroquine increasingly Intervention large sample Open-label Patient Pragmatic pragmatic trials question recommendation therapy treatment effects Trial UK RECOVERY trial Vaccines View widespread with COVID-19 [DOI] 10.1016/S2213-2600(22)00044-3 [Article Type] Review article
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article
Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3- b]Pyridine DerivativesEpoxybenzooxocino[4,3-b]Pyridine 유도체의 SARS-CoV-2에 대한 합성 및 항바이러스 특성Article Published on 2022-06-092022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity approved drug cell cultures clinically comparable compounds COVID-19 pandemic demonstrated derivative derivatives described drugs epoxybenzooxocinopyridine derivatives. half-maximal effective concentration inhibit property Replication SARS-CoV-2 SARS-CoV-2 virus Seven suppress synthesis tested the SARS-CoV-2 virus therapeutic [DOI] 10.3390/molecules27123701 PMC 바로가기 [Article Type] Article
Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSA우박 지역, KSA의 전염병 전 및 전염병 대상체에서 항-S1-RBD 항체의 혈청유병률Article Published on 2022-06-092022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] age antibodies antibody level antibody levels Antigen asymptomatic individual Asymptomatic individuals Care clinical and demographic factors clinically collected complications Containment COVID-19 Demographic factors develop Efficacy effort ELISA exhibited exposure to female females group Hail house humoral immune responses identification immune responses in-house ELISA Infection male management neutralizing antibody new SARS-CoV-2 other coronavirus other coronaviruses pandemic positive Protein RBD antigen reduced Region required Research S-RBD S1-RBD Sample SARS-CoV-2 Screen Seroprevalence serum serum antibodies serum antibody serum IgG antibodies serum IgG antibody significantly significantly higher subject Surveillance the SARS-CoV-2 Vaccine variant variants [DOI] 10.3389/fpubh.2022.874741 PMC 바로가기 [Article Type] Article
Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trialClinical Trial Published on 2022-06-072022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI administration Adverse age Antigen assigned AstraZeneca block sizes blocked clinical clinical evaluation clinically collected conducted Course COVID-19 COVID-19 vaccination death dose double-blind Efficacy enrolled enrolment Europe evaluate event Fever finding for inclusion funding individual intramuscular intramuscular injections investigators involved Japan laboratory-confirmed SARS-CoV-2 infection Latin America less Mild moderate Moderate COVID-19 monoclonal antibody combination non-hospitalised occurred Older outcomes participant Phase 3 Placebo placebo-controlled study placebo-controlled trial prevent disease progression primary endpoint progression provided randomisation randomised Randomly receive Registered required respiratory tract risk reduction RT-PCR scale severe COVID-19 severity specimen Sponsor statistically stratified study drug Symptom symptom onset the disease the placebo group treating Treatment treatment group USA WHO [DOI] 10.1016/S2213-2600(22)00180-1 [Article Type] Clinical Trial
Deep learning-based lesion subtyping and prediction of clinical outcomes in COVID-19 pneumonia using chest CT Research Published on 2022-06-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 95% confidence interval Admission AUC automatically average calculated Chest CT Clinical outcome clinical outcomes clinically Cohort collected COVID-19 CT scans deep deep learning develop Dice disease severity evaluate evaluated ICU intensive care unit Interpretation lung mechanical ventilation Metrics Negative predictive value outcome overlapping parenchymal damage patient mortality patients Pneumonia Positive predictive value predict quantification quantitative assessment Segmentation sensitivity severity Spearman correlation coefficient specificity subtype tested was used [DOI] 10.1038/s41598-022-13298-8 [Article Type] Research
The impact of COVID-19-related quarantine on psychological outcomes in patients after cardiac intervention: a multicenter longitudinal study Research Published on 2022-06-062022-10-05 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 치료법, [키워드] Anxiety BAI Beck clinically cognitive condition consequence control group COVID-19 pandemic Critical depressive Effect eight evaluated Evidence General population Health in both group Insomnia Intervention mandatory mental health morbidity and mortality multicenter negatively affected pandemic Patient patients Probability Psychological assessment psychological health Psychological outcome quarantine rehabilitation reported risk Sleep statistical analysis Support Symptom symptoms of depression turn [DOI] 10.1038/s41398-022-01984-0 [Article Type] Research