Characterization of ACE Inhibitors and AT 1 R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell ModelArticle Published on 2021-08-102022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] ACE ACE inhibitor ACE2 ACE2 mRNA angiotensin-converting enzyme 2 antagonist AT1 receptor antagonist binding Caco-2 caused Cell cell barrier integrity characterization Concentration concentrations Cytopathic effect detrimental effect drug Effect host cells in vitro induce infection rate Interaction investigated lung damage lung endothelial Model pharmacological Prevent Protein protein expression receptor reduced reducing SARS-CoV-2 SARS-COV-2 infection significantly upregulation virus replication Virus spike [DOI] 10.3390/life11080810 PMC 바로가기 [Article Type] Article
Impact of Environmental Indicators on the COVID-19 Pandemic in Delhi, IndiaArticle Published on 2021-08-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Air pollutants concentrations confirmed case contribute correlated correlation COVID-19 COVID-19 incidence COVID-19 outbreak death deaths Delhi ENhance environmental factors evaluate explain explained Factor Generalized linear model globe Humidity Impact India Indicator Infection lockdown Mortality outbreak parameter parameters rainfall Research Spread temperature Transmission Variability Wind speed with COVID-19 [DOI] 10.3390/pathogens10081003 PMC 바로가기 [Article Type] Article
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies매우 강력하고 고온에 견디며 돌연변이에 내성이 있는 나노바디에 의한 SARS-CoV-2 중화Article Published on 2021-08-092022-09-10 Journal: The EMBO Journal [Category] MERS, SARS, 변종, 진단, [키워드] Alpha alternative antibodies antibody best Beta bind Concentration concentrations Coronaviridae COVID‐19 COVID‐19 patients COVID‐19 cytosol E484K effective Epsilon Gamma immune Immunoglobulin immunoglobulins immunology include Interaction Iota L452R lineages mammalian cell mammalian cells microbial Microbiology, Virology & Host Pathogen Interaction monomer mutant strain Mutation N501Y nanobodies nanobody neutralization neutralize open Protein RBD receptor‐binding domain SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 Spike protein structures the RBD the Spike Treatment trimer Vaccine VHH antibody Viral [DOI] 10.15252/embj.2021107985 PMC 바로가기 [Article Type] Article
Effect of the COVID-19 Lockdown on Air Pollution in the Ostrava RegionCOVID-19 잠금이 오스트라바 지역의 대기 오염에 미치는 영향Article Published on 2021-08-042022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술, [키워드] Air pollution alternative analytical method cluster analysis Concentration concentrations conditions COVID-19 COVID-19 outbreak decrease Effect estimate evaluated group highest intensity lockdown measure monitoring no decrease NOx Ostrava PM2.5 Pollution Region replicate significantly subset [DOI] 10.3390/ijerph18168265 PMC 바로가기 [Article Type] Article
Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: HypothesisReviews Published on 2021-08-012022-10-28 Journal: Viral immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome appear association blood vessel blood vessels Brain cause circulation cirrhosis closely resemble concentrations coronavirus COVID-19 COVID-19 disease damage disease effective endogenous Evidence exposure to hepatocyte Hypothesis include Inflammatory Inflammatory response liver Liver damage lung Lungs manifestation metabolic syndrome organ Pathogenesis pathology prevention of COVID-19 Protein released responsible resulting retinoid retinoids retinyl ester reveal review SARS-CoV-2 Sepsis Support tissue damage toxic Treatment virus vitamin A [DOI] 10.1089/vim.2020.0330 PMC 바로가기 [Article Type] Reviews
A novel strategy for SARS-CoV-2 mass screening with quantitative antigen testing of saliva: a diagnostic accuracy study타액의 정량적 항원 검사를 통한 SARS-CoV-2 대량 스크리닝을 위한 새로운 전략: 진단 정확도 연구Article Published on 2021-08-012022-09-11 Journal: The Lancet. Microbe [Category] SARS, 치료기술, [키워드] Accuracy Antigen Asymptomatic clinically close contact Community community health Concentration concentrations Concordance COVID-19 credible interval CrI Cutoff cutoff value detect develop diagnostic Diagnostic accuracy enrolled enzyme enzyme immunoassay followed by Fujirebio Health hospitalised patient Hospitalised patients immunoassay IMPROVE initial International Japan Japanese less Local mass Mass screening Ministry of Health Nasopharyngeal swab negativity NPs participant positive Prevalence Probability proportion proportions provide quantified Quantitative Quantitative RT-PCR Result RT-PCR RT-qPCR Saliva saliva samples salivary SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleoprotein screening strategy sensitivity specificity Test tested threshold Tokyo utility was obtained Welfare [DOI] 10.1016/S2666-5247(21)00092-6 PMC 바로가기 [Article Type] Article
Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort studyResearch article Published on 2021-08-012022-10-05 Journal: The Lancet Rheumatology [Category] 바이오마커, [키워드] Acute kidney injury Altered mental status Analysis approach Biomarker center characteristic chemokine children Cincinnati clinical Coagulopathy cohort of patient cohort study Concentration concentrations conditions CXCL9 Deutsche Forschungsgemeinschaft diagnosed Diagnosis eight elevated ELISA enrolled family finding FIVE foundation Frequency funding Hyperinflammatory Hyperinflammatory syndrome IL-18 IL-6 Inflammatory Inflammatory biomarker juvenile idiopathic arthritis Kawasaki disease Laboratory laboratory feature Ligand macrophage activation macrophage activation syndrome management median median age MIS-C motif Myocardial dysfunction nine non-parametric test occur Pathogenesis pathophysiology Patient potentially life-threatening prospective cohort Protein provide S100A12 SARS-COV-2 infection Sensitivity and specificity Seven severity Shock significantly higher skin Stratification Support syndrome systemic inflammatory marker USA was done were assessed [DOI] 10.1016/S2665-9913(21)00139-9 [Article Type] Research article
One Year of the COVID‐19 Pandemic. What Do We Know and What Is Yet to Come? — The Summarising ReviewPublic Health Archive Published on 2021-07-302022-10-30 Journal: International Journal of Public Health [Category] COVID-19, MERS, [키워드] 2019-nCoV Analysis article average clinical manifestation collected Comorbidity concentrations conducted coronavirus COVID-19 COVID‐19 described deviation Epidemic evaluate examined Frequency hospitalized patients Laboratory Laboratory test marker organism pandemic pathophysiology performed Pneumonia public health required Research review SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection the disease Treatment Vaccines virus virus infection Year [DOI] 10.3389/ijph.2021.1603975 PMC 바로가기 [Article Type] Public Health Archive
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay6,218 개의 약물 및 세포 기반 분석의 가상 스크리닝에 의해 Covid-19에 대한 용도가 변경된 약물408 Published on 2021-07-272022-08-31 Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제, [키워드] anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral efficacy applied approach approved approved drug approved drugs Calu Calu-3 caused cell-based assay clinical trial clinically Compound Computational methods concentrations COVID-19 COVID-19 pandemic docking docking-based virtual screening drug drug combination drug combinations Drug repurposing drugs Effect Efficacy emodin False positive False positives Health human Calu-3 cells human lung cells IMPROVE infectious viruses inhibit SARS-CoV-2 inhibiting Interaction omipalisib predicted protease recent reduce reduced Remdesivir Replication reported Repurposed drugs resulting risk RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication screened Seven Significance similarity Spread synergistic synergistic effects therapy tipifarnib Toxicity treating COVID-19 Treatment Vero cells Virtual screening viruses [DOI] 10.1073/pnas.2024302118 PMC 바로가기 [Article Type] 408
Natural processes dominate the pollution levels during COVID-19 lockdown over IndiaArticle Published on 2021-07-232022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] aerosol amplified anthropogenic activity Bay of Bengal caused Concentration concentrations condition COVID-19 COVID-19 pandemic decrease emission Emissions Environmental chemistry Environmental impact increase in India Laboratory lockdown measure Middle East natural observation reduction regions shown south India Transport transported [DOI] 10.1038/s41598-021-94373-4 PMC 바로가기 [Article Type] Article