A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
COVID-19 infection: an overview on cytokine storm and related interventionsCOVID-19 감염: 사이토카인 폭풍 및 관련 중재에 대한 개요Review Published on 2022-05-262022-09-12 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory syndrome Affect ARDS ARDS patient cause caused conditions Coronavirus disease 2019 Coronavirus-2 COVID-19 Critically ill patient CRS Cytokine storm death defined Efficacy elevated Health IL-1 IL-17 IL1 IL6 impairment IMPROVE Infection Inflammatory response interleukin-6 Interleukins Intervention lung damage Patient patients with COVID-19 Pneumonia pro-inflammatory pro-inflammatory cytokines respiratory epithelium respiratory tract SARS-CoV-2 specific inhibitor specific treatment survival rate syndrome systemically TNF-α triggered tumor necrosis factor-alpha virus [DOI] 10.1186/s12985-022-01814-1 PMC 바로가기 [Article Type] Review
A Preliminary Study of SARS-CoV-2’s Permanence and Potential Infective Capacity in Mineromedicinal Waters of Copahue, Neuquén, Argentina아르헨티나 Neuquén Copahue의 Minermedicinal Waters에서 SARS-CoV-2의 영구성과 잠재적인 감염력에 대한 예비 연구Article Published on 2022-05-132022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acidic analyzed blind can not Capacity Cell center characterized conditions consortia Copahue Cytopathic effect decrease detectable determine expand feasibility Genome immersion bath Infection infective information inoculated Laboratory media pandemic passages PCR performed Population positive sample Potential real time real time PCR Research risk SARS-CoV-2 Seven spring water subsequent survival therapeutic thermal Treatment viability Viral load virus was selected water [DOI] 10.3390/ijerph19105923 PMC 바로가기 [Article Type] Article
Factors associated with COVID-19 vaccination intent in Singapore, Australia and Hong Kong싱가포르, 호주 및 홍콩의 COVID-19 예방 접종 의도와 관련된 요인Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] age and gender Analysis Asian association belief booster carried caused Combination conditions confirmatory factor analysis COVID-19 COVID-19 knowledge score COVID-19 pandemic COVID-19 symptom COVID-19 symptoms cross-sectional survey Digital media Efficacy eight ENhance Exploratory factor analysis Factor followed by Guidance health belief Health Belief Model help herd immunity Hong Kong Immunity Increased independent risk factor information less likelihood Loss of Smell loss of smell/taste media Micronutrient micronutrients Model morbidity and mortality new SARS-CoV-2 parameter participant Perceived Perceived risk Perception Population resulting risk SARS-CoV-2 variants seeking Self-efficacy significantly Singapore smoker susceptibility vaccination Vaccine Vaccine hesitancy Vaccine intent. variants while with COVID-19 [DOI] 10.1016/j.vaccine.2022.03.062 PMC 바로가기 [Article Type] Article
Depressive risk among Italian socioeconomically disadvantaged children and adolescents during COVID-19 pandemic: a cross-sectional online surveyCOVID-19 전염병 동안 이탈리아 사회경제적으로 불리한 아동 및 청소년의 우울 위험: 횡단면 온라인 설문조사Article Published on 2022-05-072022-09-11 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] activities activity adolescents association children Clinical data conditions COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional cross-sectional study Depression depressive depressive symptom Depressive symptoms detect Diagnosis disorders distress Effect effective emotional Emotional response Epidemic expected Factor Families family First wave form implication individual information inventory Italian lack Logistic regression analysis Low-income Mental mental health Neuropsychiatric outbreak pandemic parent participant performed potential risk problem promotion recruited risk socio-demographic Socioeconomic disadvantage. Stressor stressors subject suffered Support therapeutic strategy Version [DOI] 10.1186/s13052-022-01266-x PMC 바로가기 [Article Type] Article
A fast extraction-free isothermal LAMP assay for detection of SARS-CoV-2 with potential use in resource-limited settings자원이 제한된 환경에서 잠재적으로 사용할 수 있는 SARS-CoV-2 검출을 위한 빠른 추출이 필요 없는 등온 LAMP 분석Article Published on 2022-05-022022-09-11 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] alternative method analysed Analysis caused clinical sample clinical samples conditions country current demonstrated determine disease equipment extracted RNA extraction Extraction-free LAMP IMPROVE Incubation isothermal isothermal amplification LAMP limit of detection London management Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples non-specific not affect nucleic acid PCR phosphate Phosphate Buffered Saline primer pair primer pairs qRT-PCR Quantitative reaction reagents resource resource-limited settings RLS RNA RT-PCR RT-PCR assays SARS-CoV-2 Sensitivity and specificity significantly Spread Street suggested tested Viral viral transport media were used [DOI] 10.1186/s12985-022-01800-7 PMC 바로가기 [Article Type] Article
Eltrombopag for refractory vaccine-induced immune thrombotic thrombocytopenia난치성 백신에 의한 면역혈전성 혈소판감소증 치료제 엘트롬보팩Case Reports Published on 2022-05-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 진단, [키워드] adenoviral vector administration antibody Antigen ChAdOx1-S characterized complexes conditions Corticosteroids COVID-19 described disorder ELISA Eltrombopag enzyme-linked immunosorbent functional highlight immune Infarction Intravenous immunoglobulin introduced levels of antibody life-threatening management Patient Platelet positive potential therapy renal renal vein reported respiratory SARS-CoV-2 syndrome tested the spike protein thrombocytopenia thrombosis thrombotic vaccine administration Vaccines [DOI] 10.1007/s11239-021-02604-2 PMC 바로가기 [Article Type] Case Reports
Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque쥐 및 붉은털 원숭이에서 침팬지 아데노바이러스 기반 COVID-19 백신의 비임상 면역원성, 생체 분포 및 독성 평가Article Published on 2022-05-012022-09-12 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Adenovirus adenovirus-based biodistribution candidate vaccine caused cellular Chimpanzee Chimpanzee adenovirus vector collected conditions coronavirus COVID-19 COVID-19 vaccine develop DNA dose effective Effective vaccines elicit ENCODE evaluated full-length spike protein global pandemic Humoral response immune response immunogenicity induce injected injection Intramuscular injection intramuscularly long-lasting morbidity and mortality Neutralizing antibody response organ polymerase chain profile qPCR quantified Quantitative rhesus rhesus macaque Safe safety profile SARS-CoV-2 serotype shown T cell responses Th1 toxicology Vaccine were given [DOI] 10.1007/s00204-021-03221-x PMC 바로가기 [Article Type] Article
The effects of gratitude and kindness on life satisfaction, positive emotions, negative emotions, and COVID-19 anxiety: An online pilot experimental studyRandomized Controlled Trial Published on 2022-05-012022-10-05 Journal: Applied Psychology. Health and Well-Being [Category] 임상, [키워드] Anxiety applicability assigned baseline benefit boost caused condition conditions contribute control condition coronavirus disease COVID-19 COVID-19 anxiety COVID-19 pandemic diagnose Effect emotional experiment fatality gratitude Intervention kindness negative emotions outcome pandemic participant Positive emotion positive emotions Psychological Psychological intervention Randomly Research Satisfaction significant difference significantly higher subjective well-being [DOI] 10.1111/aphw.12306 PMC 바로가기 [Article Type] Randomized Controlled Trial
Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark덴마크 Delta 변종에 대한 Omicron SARS-CoV-2 변종 상대적 순시 번식 수Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 conditions coronavirus Delta delta variant Denmark dominant effective epidemiological Epidemiology Evolution expected GISAID database greater Infection instantaneous introduced less measure nucleotide nucleotide sequence omicron Omicron variant Omicron variants Preparing proportion rapid increase Registered relative Reproduction number SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Transmission variant variants virus widespread [DOI] 10.1002/jmv.27560 PMC 바로가기 [Article Type] Article