epithelial cell – Page 15 – Communicable Diseases Research

SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

COVID-19 유무에 관계없이 ICU 환자의 숙주 내피, 상피 및 염증 반응의 비교: 전향적 관찰 코호트 연구

Observational Study

Published on 2021-04-192022-09-11
Journal: Critical Care [Category] MERS, 바이오마커, 임상,

[키워드] Acute kidney injury acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amyloid A angiopoietin biological pathway Biomarker Blood both groups cause cell injury characteristic collected Concentration coronavirus COVID-19 Critical Critical illness Critically ill demographics diagnose diagnoses end products endothelial Endothelial dysfunction enrolled epithelial epithelial cell evaluate followed by groups Host host response ICU admission ICU patient ICU Patients in both group in-hospital mortality Inflammation Inflammatory biomarker Inflammatory response interleukin interleukin 6 Invasive mechanical ventilation involved marker Mortality Necrosis Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not different Pathways Patient plasma biomarker Pneumonia positive proportion prospective observational cohort Protein receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure Result resulting SAA SARS-CoV-2 SARS-COV-2 infection Sepsis serum amyloid severe acute respiratory syndrome Coronavirus severe COVID-19 significantly higher significantly lower sTNFR study enrollment supplementary material syndrome target targets Therapeutics Tumor tumor necrosis tumor necrosis factor Viral viral infection while
[DOI] 10.1186/s13054-021-03547-z PMC 바로가기 [Article Type] Observational Study

Giloy Ghanvati ( Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish

Pharmacology

Published on 2021-04-192022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] A549 artificial ventilation ayurved Ayurveda caused changes in comparable correlated cough disease disease phenotype distress dosage epithelial cell feature Fever giloy ghanvati granulocyte healthcare Hook human lung humanized Immune cell induced Infection infiltration inflamation Inflammation lack Macrophage Model phenotype pro-inflammatory renal tissue reported respiratory reversed SARS-CoV-2 SARS–CoV–2 spike-protein swim bladder symptomatic systemic damage targeted therapy the disease the SARS-CoV-2 therapy tinopsora cordifolia Traditional Treatment treatment group viral disease were given xenotranplantation zebrafish
[DOI] 10.3389/fphar.2021.635510 PMC 바로가기 [Article Type] Pharmacology

The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)

무기다인산의 치료 가능성: 코로나바이러스(COVID-19)를 제어하는 다목적 생리학적 고분자

Review

Published on 2021-04-152022-09-10
Journal: Theranostics [Category] MERS, SARS, 신약개발, 치료제,

[키워드] ACE2 receptor addition airway airway epithelia airways alkaline phosphatase anhydride attachment binding cationic cause caused ciliary Combination coronavirus disease Course COVID-19 damages drug therapy epithelial epithelial cell epithelial cells form Gene Expression glycoprotein help hydrolysis IMPROVE Inhaled initial life cycle metabolic energy molecule MUC1 MUC5AC mucin multiorgan failure Nanoparticles Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Particle phosphatase phosphate physiological Polymer polyp polyphosphate Prevent rationale Research residues SARS-CoV-2 significantly subsequent Support target cells the disease the RBD therapeutic potential therapy transported viral receptor-binding domain virus Virus life cycle
[DOI] 10.7150/thno.59535 PMC 바로가기 [Article Type] Review

Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2

Article

Published on 2021-04-092022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

SARS-CoV-2는 JAK1/2 종속 국소 보체 과활성화를 유도합니다.

Research Articles

Published on 2021-04-072022-09-12
Journal: Science Immunology [Category] MERS, SARS, 진단,

[키워드] ACE activated Activation affecting Alternative pathway angiotensin angiotensin converting enzyme Antiviral blocked Bronchoalveolar lavage C3 convertase C3a Cell cell lines clinical manifestation Combination combination therapy complement Complement activation Complement C3 complement component complement system convertase coronavirus disease Coronavirus disease 2019 COVID-19 disease severity disease-causing driver drug entry receptor epithelial cell epithelial cells expressed expression Genes Gut Hyperactivation implicated induce infected cells inhibited inhibitor interferon JAK inhibitor jak inhibitors JAK1 kidney kidneys liver Local lung epithelial Lung epithelial cells Lungs lymphoid normalized not affect pathway Pathways patients processing produced Protein Remdesivir respiratory epithelial cell respiratory epithelial cells ruxolitinib SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Signaling Stat1 the disease tissues transcript Transcription underlie virus
[DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles

Saliva: What Dental Practitioners Should Know about the Role of This Biofluid in the Transmission and Diagnostic of SARS-CoV-2

타액: SARS-CoV-2의 전파 및 진단에서 이 생체액의 역할에 대해 치과의사가 알아야 할 사항

Review

Published on 2021-04-062022-09-10
Journal: Medicina [Category] MERS, SARS, 치료기술,

[키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected binding Cell cells Contact contact with Contagion contribute coronavirus cough COVID-19 dental dental practice dentist dentists develop Diagnosis diagnostic diagnostic methods epithelial cell epithelial cells Evidence evidence of expected explain Express furin Health host cells include infected patient infected patients Infection information knowledge means mechanism Nasopharyngeal swab offer oral health oral tissue oral tissues outbreak pandemic Perspective Practitioner professional professionals Protein provide respiratory risk role Saliva saliva samples salivary glands SARS-CoV-2 SARS-COV-2 infection scientific evidence sneeze Spread Support Surveillance susceptible the disease tissue tissues TMPRSS Transmission variety virus
[DOI] 10.3390/medicina57040349 PMC 바로가기 [Article Type] Review

ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?

ACE2 발현은 기도 상피 세포의 인터페론 반응과 관련이 있지만 SARS-CoV-2 진입에 기능적입니까?

Article

Published on 2021-04-012022-09-11
Journal: Cytokine [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] A549 ACE2 ACE2 expression Activation addition airway airway epithelial cell analyzed association Basal cell basal cells Calu3 CaLu3 cells caused cell lines children correlation ENhance epithelial epithelial cell evaluated examined experiment full-length functional furin FURIN expression IFN IFN response IFNs in vivo interferon involved ISG15 isoform marker nasopharyngeal cells Patient performed positive correlation protease receptor Respiratory disease respiratory diseases respiratory tract risk SARS-CoV-2 SARS-COV-2 infection shown significantly the interferon Treatment Truncated ACE2 isoform. type I type I IFNs upper airway upregulated viral infections
[DOI] 10.1016/j.cyto.2021.155430 PMC 바로가기 [Article Type] Article

Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors

SARS-CoV-2 세포 진입 억제제로서의 Morus Alba의 막횡단 프로테아제 세린-2 억제제의 약리정보학 기반 식별

Original Article

Published on 2021-03-302022-09-12
Journal: Molecular diversity [Category] COVID19(2023년), SARS, 진단,

[키워드] Morus alba Linn. Abstract acute respiratory syndrome coronavirus aerodigestive tract ambroxol Amino acid amino acids analyses approach AutoDock vina binding affinity binding free energy calculated camostat complex component drug-likeness Entry inhibitor epithelial cell epithelial cells expressed FIVE free energy Glide help host cell hydrogen Hydrogen bond hydrophobic hydrophobic interaction hydrophobic interactions in-silico Infection inhibitor Interaction ligands MD simulation molecular molecular docking molecular dynamics molecule molecules Morus Alba Novel coronavirus parameter pharmacokinetic protease Protein respiratory SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection screened Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific tissue specific tissues stability suggested supplementary material the SARS-CoV-2 TMPRSS2 trajectory transmembrane Virtual screening were assessed
[DOI] 10.1007/s11030-021-10209-3 PMC 바로가기 [Article Type] Original Article

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

인간 호흡기 상피에서 SARS-CoV-2 및 SARS-CoV에 대한 서로 다른 온도 의존성 바이러스-숙주 역학

Research Article

Published on 2021-03-292022-08-13
Journal: PLoS Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] acute respiratory syndrome coronavirus Affect both virus both viruses Cell culture characteristic clinical feature coronavirus coronavirus 2 CoV infection epithelial epithelial cell exhibit Host host cell host cell response host innate immune response dynamics human respiratory epithelium human-to-human transmission dynamics infected individuals Infection influence innate immune response interferon investigated Lower respiratory tract performed Phylogenetic relationship primary human airway primary human airway epithelial cell culture model pro-inflammatory response pro-inflammatory responses public health replicated Replication replication efficiency replication kinetics respiratory respiratory viruses SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread temperature temperature-dependent interferon These data time-resolved transcriptome analysis Transcriptome transcriptome analysis transmission efficiencies type I type III interferon upper respiratory epithelium upper respiratory tract Viral viral replication viral replication kinetics virus–host dynamics virus–host interaction dynamics viruses
[DOI] 10.1371/journal.pbio.3001158 PMC 바로가기 [Article Type] Research Article