Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody designArticle Published on 2021-11-182022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] Alpha variant antibodies antibody Antibody structure Antigen Biochemistry bovine CDR CDRs complementarity-determining region contribute Critical de novo disulfide bond Efficiency experiment feature flexible high affinity Interaction MD simulation neutralize Neutralizing organized Protein Protein design remained residue SARS-CoV-2 Spike protein stability the SARS-CoV-2 unique [DOI] 10.1038/s41467-021-27103-z PMC 바로가기 [Article Type] Article
Machine Learning–Based Predictive Modeling of Anxiety and Depressive Symptoms During 8 Months of the COVID-19 Global Pandemic: Repeated Cross-sectional Survey StudyOriginal Paper Published on 2021-11-172022-10-31 Journal: JMIR Mental Health [Category] COVID-19, [키워드] Additive Adults affected age Algorithm Analysis Anxiety change Combination complex contributing to COVID-19 COVID-19 pandemic cross-sectional data-driven Depression distress Effect elevated emotion emotional emotional distress exacerbate exhibited explained Factor Factors flexible Gender global pandemic Gradient Health highest highlight identify Impact impacted lowest machine machine learning Measures mental health mental illness Model modeling Month objective pandemic Pandemics predicted prediction Principal component principal component analysis proportion question response Result risk sampling strategy second Sociodemographic characteristics Substance use survey Symptom Symptoms variable variables Variation was used were used [DOI] 10.2196/32876 PMC 바로가기 [Article Type] Original Paper
Ultrasensitive Detection of COVID-19 Causative Virus (SARS-CoV-2) Spike Protein Using Laser Induced Graphene Field-Effect Transistor레이저 유도 그래핀 전계 효과 트랜지스터를 사용한 COVID-19 원인 바이러스(SARS-CoV-2) 스파이크 단백질의 초고감도 검출Article Published on 2021-11-172022-09-10 Journal: Molecules [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition binding biosensor can not Causative caused channel Concentration conditions contagious coronavirus COVID-19 current detect detection drug early diagnosis field-effect transistor flexible flexible devices Graphene human infectious disease human serum Imbalance induced Infectious disease Isolation labeling Laboratory Laser LIG-FET nucleic acid outbreak PBS phosphate phosphate-buffered saline platform porous Protein reduction respiratory SARS-CoV-2 SARS-CoV-2 spike protein sensor severe acute respiratory syndrome Coronavirus specific antibodies specific antibody specificity spike Spike protein supply supply and demand the SARS-CoV-2 the spike protein transistor Vaccines virus [DOI] 10.3390/molecules26226947 PMC 바로가기 [Article Type] Article
Extended minimally invasive autopsy: Technical improvements for the investigation of cardiopulmonary events in COVID-19확장된 최소 침습적 부검: COVID-19의 심폐 사건 조사를 위한 기술 개선Original Article Published on 2021-11-172022-09-10 Journal: Clinics [Category] MERS, SARS, 치료기술, [키워드] Accuracy alternative Autopsy biopsies can be used Cardiopulmonary contagious COVID-19 died Diseases eight evaluated event events Evidence Extended feasible flexible heart human diseases improvement Infectious diseases invasive limitation Lungs Minimally Invasive Autopsy Myocardial infarction organ pandemic pathophysiology Patient Post-mortem post-mortem biopsy sampling technique Thoracic Thromboembolism tissue tissue sample Ultrasound vessels was performed [DOI] 10.6061/clinics/2021/e3543 PMC 바로가기 [Article Type] Original Article
Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugsResearch Article Published on 2021-11-152022-10-30 Journal: The Journal of Biological Chemistry [Category] Coronavirus, MERS, SARS, [키워드] abicipar pegol Ala antibody block clinical development clinically DARPin DARPins, designed ankyrin repeat proteins designed ankyrin repeat protein domain domains drug Drug development drug engineering electrostatic repulsion endothelial ensovibep FIVE flexible growth HER2, human epidermal growth factor receptor 2 hGABP, human guanine-adenine-binding protein HSA, human serum albumin Ile IMPROVE improvement in silico analysis inhibitor IR, internal repeat less molecular dynamics Molecular dynamics simulation Mutation N-terminal N-terminal capping repeat Protein reduce replaced responsible SARS-CoV-2 entry temperature thermostability thermostable Thr transferred Val Vascular VEGF, Vascular endothelial growth factor was increased [DOI] 10.1016/j.jbc.2021.101403 PMC 바로가기 [Article Type] Research Article
Security Engineering of Patient-Centered Health Care Information Systems in Peer-to-Peer Environments: Systematic ReviewReview Published on 2021-11-152022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] absence ACM addition addressed adverse impact Analysis article attacks Care common conducted Control COVID-19 COVID-19 proximity trackers current Data analysis database decentralization Digital Direct edge computing Engineering example Factor flexible Health Health care health information identify implementation information information infrastructures inherent Intention item library literature review Mobile health mobile phone objective overcome Patient patient-centered patients peer-to-peer Reporting Result review Safe Scholar Science Scoring searched secure security System Threats vulnerabilities vulnerability was used [DOI] 10.2196/24460 PMC 바로가기 [Article Type] Review
Early innovations in opioid use disorder treatment and harm reduction during the COVID-19 pandemic: a scoping reviewReview Published on 2021-11-132022-10-28 Journal: Addiction Science & Clinical Practice [Category] COVID-19, MERS, SARS, [키워드] approach Care conducted COVID-19 COVID-19 pandemic data extraction disorder Drug screening Emergency feasible Final FIVE flexible harm reduction highlight identify implication IMPROVE inclusion criteria Intervention involved literature Low-threshold medication Modification Opioid use disorder opioids reduction Regulation Result Safe screened Substance use telehealth telemedicine visit therapy threshold Treatment Urine [DOI] 10.1186/s13722-021-00275-1 PMC 바로가기 [Article Type] Review
Modelling the COVID-19 Mortality Rate with a New Versatile Modification of the Log-Logistic DistributionResearch Article Published on 2021-11-132022-10-31 Journal: Computational Intelligence and Neuroscience [Category] Coronavirus, MERS, SARS, [키워드] addition Analysis competing COVID-19 COVID-19 mortality cumulative determine develop distribution evaluate extension flexible Kumaraswamy mathematical maximum likelihood estimation measure mortality rate New parameter Rate reliability statistical statistical model [DOI] 10.1155/2021/8640794 PMC 바로가기 [Article Type] Research Article
Social Capital, Technological Empowerment, and Resilience in Rural ChinaArticle Published on 2021-11-122022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] adopted Capital China Community connection COVID-19 disease Effectiveness empowerment equation Factor flexible greater IMPROVE increasingly inherent measure Model pandemic pandemic resilience positive proportion Resilience risk social capital social trust stimulate Support technological empowerment [DOI] 10.3390/ijerph182211883 PMC 바로가기 [Article Type] Article
Multiple time measurements of multidimensional psychiatric states from immediately before the COVID-19 pandemic to one year later: a longitudinal online survey of the Japanese populationArticle Published on 2021-11-112022-10-29 Journal: Translational Psychiatry [Category] Coronavirus, MERS, SARS, [키워드] addition affected Anxiety component components coronavirus disease COVID-19 COVID-19 pandemic Depression dimensions Effect elevated exacerbated examined Factor female flexible Generalized linear model Genetic Human behaviour identify initial intensity Japanese Mental mental health modulate modulating multidimensional Multiple nine overlapping pandemic participated pathogenic peaked Principal component problems Psychiatric psychiatric disorder Psychiatric disorders questionnaire remained risk risk factor Symptoms trajectory uninfected Withdrawal [DOI] 10.1038/s41398-021-01696-x PMC 바로가기 [Article Type] Article