hACE2 – Page 15 – Communicable Diseases Research

The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)

Research

Published on 2021-10-182022-11-01
Journal: Chinese Medicine [Category] COVID-19,

Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses

리포터 발현 바이러스를 이용한 생체 내 SARS-CoV-2 감염 역학 분석

423

Published on 2021-10-122022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme antibody causative agent coronavirus COVID-19 COVID-19 pandemic CoVs cultured cell deleted deleting dissemination dynamic effective enzyme exhibited expressed expressing expression level fluorescent followed by Frame Genes hACE2 high stability identify in vitro in vivo in vivo imaging Infection K18 locus lung MONITOR neutralize noninvasive nucleocapsid Open reading frame ORF Pathogenesis pathogenicity Protein proteolytic cleavage public health replaced REPLACED BY Replication reporter reporter expression reporter gene reporter genes reporter viruses respiratory retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance the SARS-CoV-2 the viral nucleocapsid therapeutic intervention therapeutic interventions threat transgenic mice Treatment upstream Venus Viral viral infection viral replication virus viruses whole organism wild-type
[DOI] 10.1073/pnas.2111593118 PMC 바로가기 [Article Type] 423

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic mice

CAG 프로모터 구동 hACE2 형질전환 마우스에서 매우 민감한 SARS-CoV-2 모델

Resource and Technical Advance

Published on 2021-10-082022-09-12
Journal: JCI Insight [Category] MERS, SARS, 진단,

[키워드] acute lung injury angiotensin Angiotensin-converting enzyme animal model animal models body weight Body weight loss CAG caused chemokine Consequences COVID-19 cytokine death develop early stage elevated enzyme Genome hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunization immunized mice infected with SARS-CoV-2 Infection infection with SARS-CoV-2 injection lethality Lung injury Medicines mice Mouse models pathogenicity plasma prevented SARS-CoV-2 SARS-COV-2 infection severe symptom Spread subsequent susceptibility susceptible tandem therapeutic Therapeutics Vaccine Viral antigen weight loss
[DOI] 10.1172/jci.insight.152529 PMC 바로가기 [Article Type] Resource and Technical Advance

SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response

SARS-CoV-2 바이러스-숙주 상호작용: 현재 사용 가능한 구조 및 감염성 및 면역 반응에 대한 변이 출현의 의미

Review

Published on 2021-10-072022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종,

[키워드] acute respiratory syndrome coronavirus affecting angiotensin angiotensin converting enzyme Antibody binding binding caused coronavirus coronavirus 2 coronavirus disease coronavirus disease 19 COVID-19 death delta variant emergence enzyme functional fusion protein glycosylated hACE2 human angiotensin converting enzyme 2 immune response include Infection Infectivity initiated Interaction Mutagenesis Mutation mutations predicted Protein Protein Data Bank protein structures RBD RBD affinity receptor Receptor binding domain Recognition respiratory response S protein SARS-CoV-2 SARS-CoV-2 cell infection SARS-CoV-2 S protein SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Structure the RBD Viral viral fitness worldwide pandemic
[DOI] 10.3390/ijms221910836 PMC 바로가기 [Article Type] Review

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

수용체 결합 도메인과 N-말단 도메인 중화 항체의 조합은 SARS-CoV-2 스파이크 중화-도피 돌연변이의 생성을 제한합니다

Research Article

Published on 2021-10-052022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

[키워드] analyzed antibody approved binding characterized Combination COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors defined Effectiveness Efficacy Emergency use ENhance epitope Epitopes escape mutants FDA Generation hACE2 in vitro include inhibit less memory B-cell MOST mutant Mutation N-terminal domain NAb NAbs neutralization Neutralization assay neutralization assays neutralization potency NTD Protein RBD RBD-targeting nAbs Receptor-binding domain reduce reduced Region residue S protein SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS2 sera spike spike mutations stomatitis susceptible the RBD the receptor-binding domain therapy utility Vaccine variants variants of concern vesicular stomatitis vesicular stomatitis virus Viral viral infection VoC yeast
[DOI] 10.1128/mBio.02473-21 PMC 바로가기 [Article Type] Research Article

Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development

자연 발생 파이토케미칼로 코로나19의 SARS-CoV-2 스파이크 단백질 표적화: 약물 개발을 위한 in silico 연구

Article

Published on 2021-10-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발,

[키워드] ACE2 ACE2 receptor ACE2 receptors addition ADME Analysis angiotensin Angiotensin-converting enzyme anti-SARS-CoV-2 approved attachment binding binding free energy cascade cell surface receptor class class I fusion protein complex Compound COVID-19 disease drug-likeness engage enzyme FDA Fisetin flavonoids flavonoids and non-flavonoids free energy fusion fusion protein glycoprotein hACE2 HCQ Host host cell host cell surface host cells Hydroxychloroquine in silico indication Infection internalization membrane fusion molecular molecular docking molecular docking studies Molecular docking study molecular dynamics performed phytochemicals pre-fusion provided quercetin receptor Recognition SARS-CoV-2 SARS-CoV-2 spike protein spike spike glycoprotein Spike protein suggested targeting the SARS-CoV-2 tissue tropism transition Trigger viral envelope viral infection virus
[DOI] 10.1080/07391102.2020.1796811 PMC 바로가기 [Article Type] Article

Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19

Article

Published on 2021-10-012022-10-04
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발,

The Infection and Pathogenicity of SARS-CoV-2 Variant B.1.351 in hACE2 Mice

hACE2 마우스에서 SARS-CoV-2 변이체 B.1.351의 감염 및 병원성

Comment

Published on 2021-10-012022-09-11
Journal: Virologica Sinica [Category] SARS, 변종,

[키워드] B.1.351 hACE2 SARS-CoV-2
[DOI] 10.1007/s12250-021-00452-1 PMC 바로가기 [Article Type] Comment

Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses

다에피토프 및 교차 반응성 체액 중화 및 세포 CD4 및 CD8 반응을 유도하는 SARS-CoV-2에 대한 합성 펩타이드 백신의 전임상 평가

Research Article

Published on 2021-09-272022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단,

[키워드] adjuvant alum Amino acid antibody Antibody Response B-cell epitopes BALB/c CD4 CD8 cellular cellular immunity characterization CpG cross-reactive cysteine cysteines displaying dose epitope epitope mapping Epitopes experiment Freund’s Freund’s adjuvant generate hACE2 HLA humanized humoral identification identify immunization infected individual infected individuals K18-hACE2 mice lethal dose linear epitope linear epitopes mice Neutralizing Neutralizing antibodies neutralizing capacity overlapped peptide peptide vaccine peptides Preclinical Protein Proteins RBD Receptor-binding domain recognizing response S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants sera subunit suggested T-cell epitopes tested the receptor-binding domain titres transgenic mice vaccination Vaccine vaccine platform
[DOI] 10.1080/22221751.2021.1978823 PMC 바로가기 [Article Type] Research Article

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

치명적인 마우스 적응 SARS-CoV-2의 특성 및 구조적 기초

Article

Published on 2021-09-272022-09-10
Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE2 adaptation age Amino acid amino acid substitutions Analysis animal hosts animal model animal models binding affinity cause characterization complex cryo decrease deep deep sequencing ENhance Evolution exhibit generate hACE2 human ACE2 in vivo K417N mACE2 Microscopy molecular basis molecular mechanism Mortality mouse-adapted SARS-CoV-2 Mutation N501Y pathogenicity Pathogens platform provide RBD RBD mutation receptor Receptor binding domain reduce respiratory respiratory symptoms reveal SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 strain Sequencing severe COVID-19 severe respiratory symptoms significantly structural biology the binding affinity the RBD virus Virus-host interactions
[DOI] 10.1038/s41467-021-25903-x PMC 바로가기 [Article Type] Article