healthy individuals – Page 15 – Communicable Diseases Research

Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis

Review

Published on 2021-02-072022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다

Article

Published on 2021-02-012022-09-11
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19
[DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article

Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions

COVID-19에 대한 조사 치료는 약물 상호 작용을 통해 심실 부정맥 위험을 증가시킬 수 있습니다

Article

Published on 2021-02-012022-09-11
Journal: CPT: pharmacometrics & systems pharmacology [Category] 치료제,

[키워드] action potential Analysis Arrhythmias Azithromycin cardiac adverse event cardiac adverse events cardiac electrophysiology caused cellular Chloroquine Combination combination therapy coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug combination drug combinations Drug interactions drugs Effect Factor greater healthy individual healthy individuals heart disease heart failure increase Isolation lead Lopinavir mathematical men molecular Myocyte Patient patient group pharmacokinetics potential benefits predict predicted QT prolongation Quantitative reported risk Ritonavir Sex Simulation statistical analysis susceptible Therapies treat Treatment ventricular ventricular arrhythmias women
[DOI] 10.1002/psp4.12573 PMC 바로가기 [Article Type] Article

Unraveling the Interconnection Patterns Across Lung Microbiome, Respiratory Diseases, and COVID-19

Cellular and Infection Microbiology

Published on 2021-01-282022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] characteristic contributed COVID-19 disease Genome sequencing Gut Health healthy individuals Immunity influence interconnection intestinal knowledge lung lung immunity lung in health and disease Lung microbiome lung-gut axis methodology microbial Microbiome microbiota Pathogenesis pattern progression provide reported respiratory Respiratory disease respiratory diseases SARS-CoV-2 thought
[DOI] 10.3389/fcimb.2020.619075 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals

COVID-19 환자 및 건강한 개인에서 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인에 대한 고정형 중화 V H 항체

Research Article

Published on 2021-01-272022-09-10
Journal: Science Translational Medicine [Category] 변종, 진단,

[키워드] antibody binding binding domain composed de novo develop Evidence evidence of exposure to Genes healthy individual healthy individuals heavy chain host cells Human IgA2 IgG1 IgG2 IgG3 IGHJ6 IGHV IGHV3-53 IGHV3-66 IgM IgM isotype IgM isotypes Immunoglobulin in healthy individual in vitro infected with SARS-CoV-2 inhibit inhibiting light chains memory B cell memory B cells NAb NAbs naïve B cell naïve B cells neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody no evidence of occurred Patient patients with COVID-19 produced protective immunity RBD Receptor binding domain Replication resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain somatic mutations Spike protein subtype suggested switching the RBD Viral viral infection viral infections viral replication viruses
[DOI] 10.1126/scitranslmed.abd6990 PMC 바로가기 [Article Type] Research Article

Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection

항체와 사이토카인 생산의 상호작용으로 CXCL13이 치명적인 SARS-CoV-2 감염의 잠재적인 신규 바이오마커로 밝혀짐

Research Article

Published on 2021-01-202022-09-10
Journal: mSphere [Category] 바이오마커, 진단, 치료법,

[키워드] Activation age Alpha Analysis analyzed anti-SARS-CoV-2 antibody antibodies antibody antibody level antibody levels Antigen antigens B cell Biomarker Blood blood type chemokine chemokine CXCL13 chemotactic marker chemotactic markers Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 virus CXCL13 cytokine Cytokine analysis cytokine response Cytokines develop disease disease severity elevated Eotaxin exhibited explain gamma interferon Germinal center healthy individuals help identify IFN-γ IL-12 IL-18 IL-2 IL-4 IL-6 IL-8 immune immune response immune system Immunity immunological Immunological response Increases increases in Infection information interferon interleukin interleukin 6 involved IP-10 knowledge lethal magnitude majority marker maturation MIP-1α Necrosis novel nucleocapsid outcomes Patient patient mortality patients who survived populations Potential produced Production proinflammatory Protein provide RANTES RBD Receptor binding domain S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 immunity SARS-CoV-2 pandemic SARS-CoV-2 patient SARS-CoV-2 patients severe COVID-19 Sex significant level specificity specimens systemic immune response TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha Variation Viral Viral proteins
[DOI] 10.1128/mSphere.01324-20 PMC 바로가기 [Article Type] Research Article

Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19

SARS-CoV-2 수용체 ACE2 활성 수준은 대동맥 협착증이 있는 고령 환자에서 매우 높아집니다. COVID-19의 중증도에 대한 바이오마커로서의 ACE2의 의미

Original Article

Published on 2021-01-202022-09-11
Journal: GeroScience [Category] MERS, 바이오마커,

[키워드] ACE2 ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Aortic stenosis Biomarker blood pressure cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular diseases cellular receptor chronic inflammation circulating Clinical data coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 COVID-19 mortality COVID-19 susceptibility CRP drug Ejection fraction elderly Elderly patient elderly patients elevated flow velocity functions GFR healthy individual healthy individuals high mortality higher risk hypertension hypertensive implication independent independent of inflammatory state inhibitor inhibitory Kidney function left ventricular ejection fraction Level no effect Older Patient patients RAAS receptor ACE2 respiratory SARS-CoV-2 SARS-CoV-2 susceptibility serum severe acute respiratory syndrome Coronavirus severity of COVID-19 Support systolic pressure TAPSE the SARS-CoV-2 ventricular ventricular ejection were measured
[DOI] 10.1007/s11357-020-00300-2 PMC 바로가기 [Article Type] Original Article

SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein Region

Article

Published on 2021-01-112022-10-28
Journal: Vaccines [Category] COVID-19,

SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines

Review

Published on 2021-01-112022-10-28
Journal: Vaccines [Category] COVID-19,

Is COVID-19 a high risk factor for lung cancer? A protocol for systematic review and meta-analysis

COVID-19는 폐암의 고위험 인자입니까? 체계적인 검토 및 메타 분석을 위한 프로토콜

5700

Published on 2021-01-082022-08-31
Journal: Medicine [Category] COVID-19, meta-analysis,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approval asymptomatic patient bias risk caused Clinical outcome Clinical treatment Complication coronavirus COVID-19 database death develop eligible Ethics evaluate evaluated Evidence Guidance Health healthy individual healthy individuals heterogeneity high risk identify incidence infected with COVID-19 infected with SARS-CoV-2 International lung lung cancer lung cancer patient lung cancer patients Meta-analysis Patient peer-reviewed performed postoperative present Prevalence Prognosis protocol receive reported required research finding respiratory Risk assessment risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe pneumonia Severity rate Stata statistically Support surgical surgical treatment systematic review Treatment worse prognosis
[DOI] 10.1097/MD.0000000000023877 PMC 바로가기 [Article Type] 5700