Exploring protein hotspots by optimized fragment pharmacophoresArticle Published on 2021-05-272022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] approach average binding Chemical libraries Compound Coverage demonstrated develop drug design Drug discovery Drug discovery and development drug-target interaction Effectiveness Efficiency exhibiting hotspot identify introduced macrodomain pharmacophore pharmacophores polar protease Protein protein targets protocol representing SARS-CoV-2 target targets [DOI] 10.1038/s41467-021-23443-y PMC 바로가기 [Article Type] Article
Global Trends in Research of Macrophages Associated With Acute Lung Injury Over Past 10 Years: A Bibliometric AnalysisImmunology Published on 2021-05-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] acute lung injury Analysis applied article Bibliometrics bibliometrix Characteristics China Collection concerning core country COVID-19 disorder highest hotspot identify information inhibiting INT intractable Jiaotong University Local Lung injury Macrophage macrophages MOST over paper pathway produced recorded Regulatory retrieved Science Citation Index Shanghai Treatment trend USA VOSviewer was used Web of Science [DOI] 10.3389/fimmu.2021.669539 PMC 바로가기 [Article Type] Immunology
Pakistan’s Response to COVID-19: Overcoming National and International Hypes to Fight the PandemicViewpoint Published on 2021-05-192022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] Analysis Care catastrophic Community community health conducted coronavirus COVID-19 COVID-19 outbreak Epidemic Epidemiology Health highlight hotspot International measure Mild Pakistan pandemic Pneumonia public health emergency Public Health Emergency of International Concern response risk Spread subsequent Support the disease virus World Health Organization Wuhan, China [DOI] 10.2196/28517 PMC 바로가기 [Article Type] Viewpoint
Integrated Biophysical Modeling of the SARS-CoV-2 Spike Protein Binding and Allosteric Interactions with AntibodiesSARS-CoV-2 스파이크 단백질 결합 및 항체와의 알로스테릭 상호작용의 통합 생물물리학적 모델링Article Published on 2021-05-132022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis antibodies antibody approach binding biochemical change Cluster complexes conformational CR3022 cross-talk deep mutagenesis demonstrated domain epitope Epitopes functional Hierarchical highlighting hotspot in silico mechanism modeling modulating modulation molecular dynamics Molecular dynamics simulation molecular mechanism molecular mechanisms molecular simulations Mutation network analysis neutralization panel of antibody Perturbation plasticity Quantitative RBD Region Regulatory responses S proteins S309 SARS-CoV-2 S protein SARS-CoV-2 spike proteins sensitivity Severe acute respiratory syndrome Signaling spike spike glycoprotein Spike protein Spike proteins spike trimer the SARS-CoV-2 [DOI] 10.1021/acs.jpcb.1c00395 PMC 바로가기 [Article Type] Article
Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico ApproachMedicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 binding ACE2 receptor Anti-viral antivirals bind binding affinity binding energy binding free energy complex Compound compounds COVID-19 Curcuma docking drug design Drug discovery Dynamics eight glycosylation glycosylation site Host hotspot immunomodulatory impair in silico in-silico Infection Interaction intermolecular interaction Invasion Medicine moiety molecular dynamics phytochemical plant Protein RBD respiratory disorders SARS-CoV-2 SARS-COV-2 infection screened spike Spike protein spike-ACE2 stability subsequent Syzygium targeting the binding affinity these compound Traditional Traditional medicine Treatment Virologist [DOI] 10.3389/fmed.2021.672629 PMC 바로가기 [Article Type] Medicine
Bayesian spatiotemporal forecasting and mapping of COVID‐19 risk with application to West Java Province, IndonesiaResearch Article Published on 2021-05-072022-10-30 Journal: Journal of Regional Science [Category] COVID-19, [키워드] applied Bayesian Bayesian analysis cause coronavirus disease country COVID‐19 COVID‐19 Forecasting hotspot incidence Indonesia Infection information knowledge mapping methodology Model outbreak Outbreaks pure model risk spatiotemporal Spatiotemporal distribution Spread West [DOI] 10.1111/jors.12533 PMC 바로가기 [Article Type] Research Article
The heterogeneity of the COVID-19 pandemic and national responses: an explanatory mixed-methods studyResearch Published on 2021-05-012022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] adopted America approach Asia Australia Brazil China Community comparison coronavirus disease country Coverage COVID-19 COVID-19 pandemic COVID-19 pandemic response cumulative death deaths disease effective epidemiological Europe explained Factor geographic location Germany Health heterogeneity heterogeneous highest hospital hotspot Intervention Italy medical service National New New Zealand nine non-communicable diseases outcome pandemic performed public health Region response Result selected South Korea spread to Thailand the United State Threats understanding United States Variability Wuhan, China [DOI] 10.1186/s12889-021-10885-8 PMC 바로가기 [Article Type] Research
Will the extraction of COVID-19 from wastewater help flatten the curve?폐수에서 COVID-19를 추출하면 곡선을 평평하게 만드는 데 도움이 될까요?Article Published on 2021-05-012022-09-11 Journal: Chemosphere [Category] SARS, 치료기술, [키워드] absence And disadvantages approach Blancmange challenges complex coronavirus country COVID-19 determine Disadvantages distributions Efficiency excreta expel extraction Extraction method feces help hotspot humans hygiene identify lack Limited lockdown Log-normal distribution mathematical methodology movement Normal distribution Occurrence persistence quantification recommendation Research resulting Sanitation SARS-CoV-2 sewage suggested temperature Transmission Treatment Viral load waste wastewater Wastewater treatment widespread [DOI] 10.1016/j.chemosphere.2020.129429 PMC 바로가기 [Article Type] Article
Unravelling the early warning capability of wastewater surveillance for COVID-19: A temporal study on SARS-CoV-2 RNA detection and need for the escalationCOVID-19에 대한 폐수 감시의 조기 경보 기능 풀기: SARS-CoV-2 RNA 탐지 및 확대 필요성에 대한 임시 연구Article Published on 2021-05-012022-09-11 Journal: Environmental research [Category] SARS, 치료기술, [키워드] analyzed approach Asymptomatic case average can not city clinical test Clinical tests Concentration confirmed case confirmed cases coronavirus COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic declined Early warning system Escalation fluctuation Genome help hotspot hour identify India lead management offer ORF pandemic plant positive pre-symptomatic predict Registered S-gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA SARS-CoV-2 RNA detection study period Surveillance Treatment Variation wastewater wastewater based epidemiology wastewater surveillance water [DOI] 10.1016/j.envres.2021.110946 PMC 바로가기 [Article Type] Article
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV Research Published on 2021-04-122022-10-05 Journal: Nature [Category] SARS, 신약개발, 치료제, [키워드] Antiviral effect autophagy both viruses cellular interaction Coronaviruses COVID-19 dataset drug dysregulated fibrosis heterogeneity highlight Host Host-directed therapies hotspot human cell infection with SARS-CoV-2 inhibitor integration Interaction kinase knowledge matrix metalloprotease molecular function molecular mechanism ORF3 ORF8 pathogenic pathway Perturbation phosphoproteome proteome proteomics reveal SARS-CoV SARS-CoV-2 Spread TGF-β These data tissue to define Transcriptome Viral protein virus virus–host interaction [DOI] 10.1038/s41586-021-03493-4 [Article Type] Research