Comprehensive Comparison of RNA-Seq Data of SARS-CoV-2, SARS-CoV and MERS-CoV Infections: Alternative Entry Routes and Innate Immune ResponsesSARS-CoV-2, SARS-CoV 및 MERS-CoV 감염의 RNA-Seq 데이터 종합 비교: 대체 진입 경로 및 선천적 면역 반응Immunology Published on 2021-05-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] A549 A549 cell A549 cells ACE2 Analysis Calu3 CaLu3 cells Cell cell entry cell type cells Comparative analysis complex Comprehensive COVID-19 patients dataset dose Evidence evidence of example expressing expression Factor human ACE2 IFNs immune responses imperative inefficient Infection Injury Innate innate immune response innate immune responses Innate immunity interferon interferons investigated ISGs mechanism MERS-CoV organs Pathogenesis pathogenesis of COVID-19 performed produced response Result RNA-seq data route SARS-CoV SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection second Support therapy These data TMPRSS2 transduced vector Viral viral entry virus virus entry route [DOI] 10.3389/fimmu.2021.656433 PMC 바로가기 [Article Type] Immunology
Mechanism of Ligand Recognition by Human ACE2 Receptor인간 ACE2 수용체에 의한 리간드 인식 메커니즘Article Published on 2021-05-272022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 신약개발, 치료제, [키워드] accelerated ACE2 ACE2 receptor active site acute respiratory syndrome addressed Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding conformational conformations coronavirus coronaviruses SARS-CoV Critical diabetes Diseases drug design drug target enzyme epithelial cell epithelial cells expected experimental structure expressed facilitate flexible heart heart failure homeostasis Human human ACE2 human ACE2 receptor human diseases hypertension inhibitor kidney Ligand Lungs mechanism MLN-4760 molecular molecular dynamics pancreas pulmonary diseases receptor Recognition Regulation renal Renin renin-angiotensin system SARS-CoV-2 Severe acute respiratory syndrome X-ray [DOI] 10.1021/acs.jpclett.1c01064 PMC 바로가기 [Article Type] Article
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil브라질 마나우스의 P.1 SARS-CoV-2 계통의 유전체학 및 역학Research Article Published on 2021-05-212022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] accelerate accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed angiotensin angiotensin-converting enzyme 2 binding Brazil Characteristics circulation CLOCK coronavirus country COVID-19 cases Critical death disease spread E484K enhanced Epidemiology Evolution faster Genome sequencing genomic Genomics Health human ACE2 Immune escape immune evasion indicated Infection Lineage lineages Local molecular molecular evolution mortality data mutations N501Y occurred P.1 pandemic pattern primary care provide reached receptor respiratory SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Science Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread spread of COVID-19 suffered Surveillance the spike protein Transmissibility Transmission Trio variant variants variants of concern virus viruses [DOI] 10.1126/science.abh2644 PMC 바로가기 [Article Type] Research Article
Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS‐CoV‐2Research Article Published on 2021-05-192022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] 3D structure ACE2 acute respiratory syndrome Amino acid Analysis binding calculated Comparative Contact coronavirus coronavirus disease enzyme Fisher exact test Genome human ACE2 humans hydrophobic Infection lack less livestock occur Outbreaks Probability receptor residue risk SARS‐CoV‐2 SARS‐CoV‐2 searched selected Seven susceptibility susceptible TMPRSS2 TMPRSS2 protease Transmission Vertebrate vertebrates virus [DOI] 10.1002/jmv.27073 PMC 바로가기 [Article Type] Research Article
Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질에 의해 인식이 변경된 인간 ACE2 변이체의 발견Research Article Published on 2021-05-122022-09-10 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 ACE2 residue ACE2 residues ACE2 sequence Analysis axis Clinical trial design complementary COVID-19 epidemiological facilitate Genetic variant human ACE2 identify Interaction mutant Recognition Research SARS-CoV-2 single-nucleotide SNVs Spike protein strain the SARS-CoV-2 understanding utility variant virus [DOI] 10.1371/journal.pone.0251585 PMC 바로가기 [Article Type] Research Article
Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike408 Published on 2021-05-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor bind binding Cell cells complex conserved contribute docking Effect epitope glycan glycosylated glycosylation host cells human ACE2 human ACE2 receptor human Angiotensin-converting enzyme human cells infect Infection inhibitors interact Interaction interfere MD simulation molecular molecular dynamics N322 N90 Neutralizing antibodies neutralizing antibody opposite PROTECT RBD receptor Receptor binding domain receptor protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 virus Significance Spike protein sugar sugars susceptibility the RBD the SARS-CoV-2 the spike protein translocation Trigger virus Virus-host interaction [DOI] 10.1073/pnas.2100425118 PMC 바로가기 [Article Type] 408
In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (M pro )Article Published on 2021-05-102022-10-30 Journal: Molecules [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affinity Anti-SARS-CoV-2 Activity antiviral activity binding energy binding mode candidate carried caused China co-crystallized Compound coronavirus COVID-19 disease docking result drug-likeness examined hACE2 Human human ACE2 in silico Interaction Isoflavonoid isoflavonoids Ligand M pro main protease molecular docking Molecular docking study pandemic Physicochemical properties Potential reported SARS-CoV-2 specific treatment targeting Toxicity unique WHO widespread [DOI] 10.3390/molecules26092806 PMC 바로가기 [Article Type] Article
Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyteOriginal Investigation Published on 2021-05-072022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor affecting alterations Autopsies Autopsy binding cardiomyocyte cellular entry coronavirus disease COVID-19 COVID-19 infection Deceased diabete diabetes diagnosed domain Effect evaluate evaluate the effect evaluated expression Glucose glycosylated glycosylated forms hACE2 heart Hospitalized human ACE2 in vitro include Infection Invasion investigated Italy lysine mechanism Modification monomeric myocardial damage objective oligomerization Patient patients patients with diabete protease Protein rationale residue SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV2 Serine spike supplementary material susceptibility tissue TMPRSS2 TMPRSS2 protein Total transmembrane upregulation viral invasion was performed [DOI] 10.1186/s12933-021-01286-7 PMC 바로가기 [Article Type] Original Investigation
Fast Prediction of Binding Affinities of the SARS-CoV-2 Spike Protein Mutant N501Y (UK Variant) with ACE2 and Miniprotein Drug CandidatesSARS-CoV-2 스파이크 단백질 돌연변이 N501Y(영국 변이체)와 ACE2 및 미니단백질 약물 후보의 결합 친화도에 대한 빠른 예측Article Published on 2021-05-062022-09-11 Journal: The journal of physical chemistry. B [Category] MERS, SARS, 변종, 치료제, [키워드] ACE2 affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach B.1.1.7 bind binding binding affinities binding affinity binding free energies binding free energy calculated candidate complex creating decrease demonstrated drug drug candidates drug resistance experimental structure explain free energies free energy Free energy calculations hACE2 host cells human ACE2 identified variant increase Lineage Lineage B.1.1.7 miniprotein mutant N501Y N501Y mutation overcome predict predicted prediction Protein Protein binding reported SARS-CoV-2 spike protein SARS-CoV-2 virus spike Spike protein the binding affinity the SARS-CoV-2 the spike protein therapeutic United Kingdom variant Viral viral entry [DOI] 10.1021/acs.jpcb.1c00869 PMC 바로가기 [Article Type] Article
Computational search for drug repurposing to identify potential inhibitors against SARS-COV-2 using Molecular Docking, QTAIM and IQA methods in viral Spike protein – Human ACE2 interfaceResearch article Published on 2021-05-012022-10-05 Journal: Journal of Molecular Structure [Category] 신약개발, [키워드] ACE2 acting Combination Human human ACE2 identify in viral inhibit inhibitor inhibitory effect Interaction interaction site Laboratory test Ligand ligands molecular docking pandemic positioned Protein Region spike the Spike virus [DOI] 10.1016/j.molstruc.2021.130076 [Article Type] Research article